Molecular Alterations in Ferroptosis and the Effects of Resveratrol: A Systematic Review
Ferroptosis is a cell death mechanism characterized by iron overload, accumulation of reactive oxygen species, deficits in glutathione metabolism, lipid peroxidation, and mitochondrial impairments. Resveratrol can prevent or reverse these alterations by chelating iron and upregulating antioxidant defenses. ABSTRACT Ferroptosis is an iron‐dependent cell
Ana Beatriz Dos Santos+4 more
wiley +1 more source
Shexiang Tongxin Dripping Pills regulates SOD/TNF-α/IL-6 pathway to inhibit inflammation and oxidative stress to improve myocardial ischemia-reperfusion injury in mice. [PDF]
Du W+8 more
europepmc +1 more source
Loss of Intracellular Dystrophin-A Potential Mechanism for Myocardial Reperfusion Injury-
Shiori Kyoi+8 more
openalex +2 more sources
The Interplay of Cross‐Organ Immune Regulation in Inflammation and Cancer
Organs interact dynamically through immune regulation, influencing systemic immune responses and disease progression. We review molecular and cellular mechanisms of cross‐organ immune regulation in inflammation and cancer, focusing on gut, liver, and brain interactions with other organs.
Jie Dou+6 more
wiley +1 more source
A bibliometric review and visualization of research on myocardial ischemia/reperfusion injury in patients with diabetes mellitus from 2004 to 2024. [PDF]
Yang Y, Dou J, Wu Y.
europepmc +1 more source
MicroRNA‐100‐5p Exacerbates Myocardial Ischemia–Reperfusion Injury Through Downregulation of PRMT5 [PDF]
MiR‐100‐5p overexpression downregulates PRMT5, leading to increased PTEN activity and reduced AKT signaling. This molecular cascade promotes cardiomyocyte apoptosis, enhances fibrotic remodeling, and exacerbates cardiac dysfunction following myocardial ischemia–reperfusion injury.
Wang Z+9 more
europepmc +2 more sources
Macrophage Signaling Pathways in Health and Disease: From Bench to Bedside Applications
Macrophage functions in phagocytosis, tissue repair, immune regulation, and neuronal network protection. And graphic abract image in the attachment. ABSTRACT Macrophages exhibit remarkable functional plasticity by dynamically polarizing into proinflammatory or antiinflammatory subsets in response to microenvironmental cues. This duality underpins their
Yongquan Chi+6 more
wiley +1 more source
Comprehensive bioinformatics analysis and experimental verification identify mitochondrial gene Dgat2 as a novel therapeutic biomarker for myocardial ischemia-reperfusion. [PDF]
Li H+8 more
europepmc +1 more source