Results 251 to 260 of about 285,668 (333)

Modified mRNA-Based Therapeutic Strategies for Myocardial Ischemia-Reperfusion Injury. [PDF]

Int J Mol Sci
Cai T, Yang XQ.
europepmc   +1 more source

Targeting the Nrf2/TGF‐β1/Smad Signaling Pathway: A Novel Strategy for Urolithin A to Alleviate Renal Fibrosis

Food Frontiers, Volume 7, Issue 2, March 2026.
The diagram of the mechanism of action by which UroA regulates RF. ABSTRACT The global prevalence and mortality rates associated with chronic kidney disease (CKD) have been on a continuous rise over recent decades. Renal fibrosis (RF) serves as a critical factor in the progression of CKD to end‐stage renal disease.
Xue Wu, Jiating Li, Yonghui Dong, Jia Li, Ji Bian, Chao Liu, Hongbo Zhang, Lin Han, Min Wang   +8 more
wiley   +1 more source

High-Intensity Interval Training Attenuates Inflammation in Cardiorenal Syndrome Induced by Renal Ischemia-Reperfusion Injury in Rats. [PDF]

Life (Basel)
Tsao PC, Lai CC, Fu SK, Yu CH, Chen JH, Tang CY.   +5 more
europepmc   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Myocardial stunning: mechanisms, molecular insights, and gaps in knowledge. [PDF]

Biosci Rep
Al-Awar A, Khan AW, Hussain S.
europepmc   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Mitochondrial Permeability Transition Pore: The Cardiovascular Disease's Molecular Achilles Heel. [PDF]

Biomedicines
Nesci S, Rubattu S.
europepmc   +1 more source

Real Time Evaluation of Whole Organ Perfusion by Magnetic Resonance Imaging in Ex Vivo Machine‐Perfused Liver

NMR in Biomedicine, Volume 39, Issue 3, March 2026.
Porcine livers underwent mechanical perfusion inside an MRI scanner, enabling dynamic quantitative measurements of whole organ perfusion. Vascular segmentation down to 0.45 mm resolution allowed quantification of morphological features such as vessel tortuosity, while Dynamic Contrast Enhanced MRI and diffusion weighted imaging was used to produce ...
Zainab L. Rai, Natalie A. Holroyd, Morenike Magbagbeola, Emre Doganay, Katie Doyle, Lucy Caselton, Agostino Stilli, Danail Stoyanov, Simon Walker‐Samuel, Brian R. Davidson   +9 more
wiley   +1 more source

Predictive Value of Apelin-36 for No-Reflow Phenomenon in STEMI Patients. [PDF]

Life (Basel)
Krasniqi X, Jakupi X, Vincelj J, Gojani G, Çuni P, Shahini L, Berisha A, Jashari K, Berisha B, Bakalli A.   +9 more
europepmc   +1 more source

BAK and BAX: Therapeutic Targets for Acute Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury. [PDF]

Biology (Basel)
Xu Z, Meng F, Yang H, Liu Y, Ye K, Qin F, Liu D, Dai H.   +7 more
europepmc   +1 more source