Results 261 to 270 of about 123,463 (303)
Some of the next articles are maybe not open access.
Myocardial ischemia and reperfusion injury
Cardiovascular Pathology, 2005Myocardial ischemic injury results from severe impairment of coronary blood supply and produces a spectrum of clinical syndromes. As a result of intensive investigation over decades, a detailed understanding is now available of the complexity of the response of the myocardium to an ischemic insult.
openaire +2 more sources
Reperfusion injury, stunning and myocardial viability
Australian and New Zealand Journal of Medicine, 1993Abstract:Recent experimental data suggest that current thrombolytic strategies may not yet have achieved their full potential for myocardial salvage. In fact, reperfusion may result in microvascular and myocardial cellular injuries. These may translate into transient loss of contractile function (‘myocardial stunning’), and possibly contribute to the ...
A, Tonkin, R, Chan
openaire +2 more sources
1999
Abstract Early in the history of cardiac surgery, it was recognized that some patients who underwent technically successful operations suffered from a syndrome of low cardiac output in the early postoperative period. It was also apparent that the perioperative mortality was increased in these patients. Autopsy and clinical studies in the
Robert C Gorman, Timothy J Gardner
openaire +1 more source
Abstract Early in the history of cardiac surgery, it was recognized that some patients who underwent technically successful operations suffered from a syndrome of low cardiac output in the early postoperative period. It was also apparent that the perioperative mortality was increased in these patients. Autopsy and clinical studies in the
Robert C Gorman, Timothy J Gardner
openaire +1 more source
Pharmacological therapy for myocardial reperfusion injury
Current Opinion in Pharmacology, 2004In the ischemic myocardium, reperfusion is necessary for the salvage of cells and cardiac function. However, reperfusion itself causes 'reperfusion injury', leading to the damage of myocardial cells. This is reduced by several interventions, as measured by the limitation of infarct size or reduction of arrhythmias.
George V, Moukarbel +2 more
openaire +2 more sources
Myocardial postconditioning: reperfusion injury revisited
American Journal of Physiology-Heart and Circulatory Physiology, 2005coronary heart disease is the leading cause of death in the Western world and represents one of the major burdens on healthcare systems today. Targeting those strategies that limit the damage sustained as a result of a lethal ischemic insult has been a major goal for many years.
Andrew, Tsang +2 more
openaire +2 more sources
Connexin43 and Myocardial Ischemia-Reperfusion Injury
Cardiovascular & Hematological Disorders-Drug Targets, 2018Recently, the treatment and prevention of ischemic cardiomyopathy is one of the emerging research topics in the cardiovascular field. Gap junction is the basic structure of cardiac electrophysiology. Connexin is the basic unit of gap junctions. Connexin43(CX43) is the most abundant member of Cx family in the heart, the normal expression of Cx43 is ...
Lingyun, Zu +4 more
openaire +2 more sources
Timing of Treatment for Myocardial Reperfusion Injury
Journal of Cardiovascular Pharmacology, 1999Early reperfusion of acute myocardial infarctions halts cell death due to ischemia but causes further injury, probably by oxidant mechanisms. We identified the window of opportunity during which antioxidants must be present in therapeutic concentrations to prevent reperfusion injury during 90 min of ischemia and 48 h of reperfusion in 57 dogs.
L D, Horwitz, Y, Kong, A D, Robertson
openaire +2 more sources
Zinc and myocardial ischemia/reperfusion injury
BioMetals, 2013As an important trace element, zinc is required for the normal cellular structure and function, and impairment of zinc homeostasis is associated with a variety of health problems including cardiovascular disease. Zinc homeostasis is regulated through zinc transporters, zinc binding molecules, and zinc sensors.
Zhelong, Xu, Juan, Zhou
openaire +2 more sources
Free radicals and myocardial reperfusion injury
British Medical Bulletin, 1993Ischaemic myocardial tissue will, inevitably, necrose if blood flow is not restored. Whilst reperfusion is always beneficial in terms of potential recovery of heart muscle, reperfusion in itself is believed to bring about cellular injury. While the causes of this 'reperfusion injury' are apparently multifactorial, there is now an increasing body of ...
openaire +2 more sources
Bucillamine Prevents Myocardial Reperfusion Injury
Journal of Cardiovascular Pharmacology, 2001Injury during reperfusion can partially offset the benefit of relief of ischemia in myocardial infarctions rapidly treated with thrombolytic drugs or angioplasty. We assessed whether bucillamine (N-[2-mercapto-2-methylpropionyl]-L-cysteine) is potentially useful to treat myocardial reperfusion injury.
L D, Horwitz, N A, Sherman
openaire +2 more sources