Results 251 to 260 of about 123,463 (303)

TRIM28 Is an E3 Ligase of IRP2 Suppressing Ischemia/Reperfusion-Induced Myocardial Ferroptosis. [PDF]

open access: yesCirculation
Zhu K   +21 more
europepmc   +1 more source

Myocardial Reperfusion Injury

open access: yesNew England Journal of Medicine, 2007
Lethal reperfusion injury is a paradoxical type of myocardial injury caused by the restoration of coronary blood flow after an ischemic episode. This review focuses on the mechanisms of the injury, on attempts to protect the heart against it, and on promising new approaches to cardioprotection during percutaneous coronary intervention.
Derek M Yellon, Derek J Hausenloy
exaly   +11 more sources

Mechanisms of myocardial reperfusion injury

The Annals of Thoracic Surgery, 1999
Reperfusion of the ischemic myocardium results in irreversible tissue injury and cell necrosis, leading to decreased cardiac performance. While early reperfusion of the heart is essential in preventing further tissue damage due to ischemia, reintroduction of blood flow can expedite the death of vulnerable, but still viable, myocardial tissue, by ...
J L, Park, B R, Lucchesi
openaire   +2 more sources

Myocardial Reperfusion Injury

Critical Care Nursing Clinics of North America, 1990
A review of the mechanism of ischemic-reperfusion injury, proposed interventions to prevent injury, and future directions have been presented to enhance the practitioner's knowledge of this new, exciting concept in myocardial injury. There is increasing evidence in the literature that reperfusion injury may occur in other organ systems and is ...
openaire   +2 more sources

Neutrophils and myocardial reperfusion injury

Pharmacology & Therapeutics, 1996
Ischaemia induces an acute inflammatory response in myocardial tissue with an early phase of neutrophil accumulation, which is accelerated by reperfusion. In experimental models, interventions that deplete neutrophils or inhibit their function cause a significant reduction in myocardial infarct size. These cells, therefore, may exacerbate tissue injury
openaire   +2 more sources

Unresolved issues in myocardial reperfusion injury

Cardiovascular Pathology, 2010
While the basic pathobiology of myocardial ischemic injury and reperfusion has been determined over the last 50 years, there are important, unresolved, or at least not completely elucidated, issues in the field. These include the relative contributions of different modes of cell injury and death to evolving myocardial infarcts; interactions of ...
Louis Maximilian, Buja   +1 more
openaire   +2 more sources

Peroxynitrite in Myocardial Ischemia-Reperfusion Injury

Heart Failure Reviews, 2002
Peroxynitrite is a highly reactive oxidant which is produced during reperfusion of the ischemic heart. The role that this molecule plays in reperfusion injury has been controversial. Many investigations have demonstrated toxic effects of peroxynitrite, whereas others have found it to be protective during reperfusion.
Manoj M, Lalu   +2 more
openaire   +2 more sources

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