Results 371 to 380 of about 282,175 (385)

Pathophysiology of Myocardial Reperfusion Injury

2012
The debate over the existence and nature of lethal reperfusion injury has been sustained by the fact that we do not know exactly why an ischemic insult kills cells in the first place. While the mechanism of lethal ischemia is far from fully understood, much is known about it, and it is not simply a matter of cells starving to death from lack of ...
Michael V. Cohen, James M. Downey
openaire   +2 more sources

Regulated cell death in myocardial ischemia–reperfusion injury

Trends in endocrinology and metabolism, 2023
Qi Xiang, Xin Yi, Xue-Hai Zhu, Xiang Wei, D. Jiang   +4 more
semanticscholar   +1 more source

Melatonin attenuates myocardial ischemia‐reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK‐OPA1 signaling pathways

Journal of Pineal Research, 2019
Optic atrophy 1 (OPA1)‐related mitochondrial fusion and mitophagy are vital to sustain mitochondrial homeostasis under stress conditions. However, no study has confirmed whether OPA1‐related mitochondrial fusion/mitophagy is activated by melatonin and ...
Y. Zhang, Yue Wang, Junnan Xu, F. Tian, Shunying Hu, Yundai Chen, Zhenhong Fu   +6 more
semanticscholar   +1 more source

Perioperative myocardial ischemia reperfusion injury

Anesthesiology Clinics of North America, 2003
Myocardial I-R injury contributes to adverse cardiovascular outcomes after cardiac surgery. The pathogenesis of I-R injury is complex and involves the activation, coordination, and amplification of several systemic and local proinflammatory pathways (Fig. 4).
openaire   +3 more sources

Cellular recruitment in myocardial ischaemia/reperfusion injury

European Journal of Clinical Investigation, 2016
AbstractBackgroundMyocardial infarction (MI) is strictly linked to atherosclerosis. Beyond the mechanical narrowing of coronary vessels lumen, during MI a great burden of inflammation is carried out. One of the crucial events is represented by the ischaemia/reperfusion injury, a complex event involving inflammatory cells (such as neutrophils, platelets,
BONAVENTURA, ALDO, MONTECUCCO, FABRIZIO, DALLEGRI, FRANCO   +2 more
openaire   +4 more sources

'Myocardial Ischemia-Reperfusion Injury and the Influence of Inflammation.

Trends in cardiovascular medicine, 2022
M. Algoet, S. Janssens, U. Himmelreich, W. Gsell, M. Pusovnik, J. van den Eynde, W. Oosterlinck   +6 more
semanticscholar   +1 more source

Free radicals and myocardial reperfusion injury

British Medical Bulletin, 1993
Ischaemic myocardial tissue will, inevitably, necrose if blood flow is not restored. Whilst reperfusion is always beneficial in terms of potential recovery of heart muscle, reperfusion in itself is believed to bring about cellular injury. While the causes of this 'reperfusion injury' are apparently multifactorial, there is now an increasing body of ...
openaire   +3 more sources

Myocardial ischaemia–reperfusion injury and cardioprotection in perspective

Nature Reviews Cardiology, 2020
G. Heusch
semanticscholar   +1 more source

Inhibition of ceramide de novo synthesis as a postischemic strategy to reduce myocardial reperfusion injury

Basic Research in Cardiology, 2016
M. R. Reforgiato, G. Milano, Gemma Fabriàs, Josefina Casas, Paolo Gasco, Rita Paroni, Michele Samaja, Riccardo Ghidoni, A. Caretti, P. Signorelli   +9 more
semanticscholar   +1 more source

Statin and myocardial ischemia-reperfusion injury

International Journal of Cardiology, 2016
Yao Lu, Jun Hu
openaire   +3 more sources