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Ischemic preconditioning affects phosphosites and accentuates myocardial stunning while reducing infarction size in rats [PDF]

Frontiers in Cardiovascular Medicine
Background and aimsIschemic preconditioning (IPC), i.e., brief periods of ischemia, protect the heart from subsequent prolonged ischemic injury, and reduces infarction size. Myocardial stunning refers to transient loss of contractility in the heart after
Ahmed Elmahdy, Ahmed Elmahdy, Aaron Shekka Espinosa, Aaron Shekka Espinosa, Yalda Kakaei, Yalda Kakaei, Tetiana Pylova, Tetiana Pylova, Abhishek Jha, Abhishek Jha, Ermir Zulfaj, Maryna Krasnikova, Maryna Krasnikova, Amin Al-Awar, Amin Al-Awar, Zahra Sheybani, Zahra Sheybani, Valentyna Sevastianova, Valentyna Sevastianova, Evelin Berger, Amirali Nejat, Linnea Molander, Linnea Molander, Erik Axel Andersson, Erik Axel Andersson, Elmir Omerovic, Elmir Omerovic, Shafaat Hussain, Shafaat Hussain, Björn Redfors, Björn Redfors, Björn Redfors   +31 more
doaj   +5 more sources

ATP—Sensitive Potassium Channel Opener Diazoxide Reduces Myocardial Stunning in a Porcine Regional With Subsequent Global Ischemia Model [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background ATP‐sensitive potassium channels are inhibited by ATP and open during metabolic stress, providing endogenous myocardial protection. Pharmacologic opening of ATP potassium channels with diazoxide preserves myocardial function following ...
Ana K. Velez, Eric Etchill, Katherine Giuliano, Sean Kearney, Melissa Jones, Jie Wang, Brian Cho, Mary Beth Brady, Jeffrey Dodd‐o, Joseph M. Meyer, Jennifer S. Lawton   +10 more
doaj   +3 more sources

Myocardial stunning secondary to erroneous administration of intravenous epinephrine [PDF]

SAGE Open Medical Case Reports, 2023
Epinephrine is a commonly used medication for emergent conditions, such as anaphylaxis, respiratory distress, and shock. However, its versatility can also lead to iatrogenic errors in dosages, concentrations, and routes of administration. In this case, a
Girish Pathangey, Rohitha Moudgal, Christopher Lee, Stanislav Henkin   +3 more
doaj   +3 more sources

Three-vessel myocardial bridging: A possible cause of myocardial stunning

Revista Portuguesa de Cardiologia, 2019
The authors report a rare clinical case of myocardial bridging of the three major coronary arteries, which manifested in an unusual way with severe biventricular dysfunction in the context of tachycardia.
Ana Rita Almeida, Ana Rita Pereira, Gonçalo Morgado, Maria José Loureiro, Filipa Ferreira, Inês Cruz, Luís Rocha Lopes, Hélder Pereira   +7 more
doaj   +3 more sources

Mechanisms of Myocardial Stunning in Stress-Induced Cardiomyopathy

Cardiovascular Innovations and Applications, 2022
Stress-induced cardiomyopathy, in contrast to acute myocardial infarction, is a type of acute heart failure characterized by reversible left ventricular dysfunction.
Quanwei Pei, Nadine Mbabazi, Lina Zou, Junpei Zhang, Hongpeng Yin, Bin Li, Jiaxin Wang, Weifa Wang, Pengqi Lin, Junjie Yang, Dechun Yin   +10 more
doaj   +2 more sources

Myocardial stunning occurs during intermittent haemodialysis for acute kidney injury. [PDF]

Intensive Care Med, 2017
Mahmoud H, Forni LG, McIntyre CW, Selby NM.   +3 more
europepmc   +4 more sources

Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes. [PDF]

Crit Care Med, 2020
Supplemental Digital Content is available in the text. Objectives: Cardiogenic shock following cardiopulmonary resuscitation for sudden cardiac arrest is common, occurring even in the absence of acute coronary artery occlusion, and contributes to high ...
Piao L, Fang YH, Hamanaka RB, Mutlu GM, Dezfulian C, Archer SL, Sharp WW.   +6 more
europepmc   +2 more sources

Quantitative proteomic and phosphoproteomic profiling of ischemic myocardial stunning in swine.

Am J Physiol Heart Circ Physiol, 2020
Despite decades of research on pathophysiology of myocardial stunning, protein changes and/or phosphorylation status underlying alterations in cardiac function/structure remain inadequately understood.
Wang X, Shen X, Weil BR, Young RF, Canty JM, Qu J.   +5 more
europepmc   +2 more sources

Myocardial stunning in hyperthyroidism [PDF]

Clinical Cardiology, 2000
AbstractThe cases of two patients with hyperthyroidism and acute left ventricular (LV) dysfunction with segmental wall motion abnormalities resulting in heart failure are reported. Both had electrocardiographic changes mimicking ischemic coronary artery disease.
Naveen L. Pereira, G. William Dec, Joseph Choo, Roger J. Hajjar, Alfred F. Parisi, Paul Gordon   +5 more
openalex   +5 more sources

Metformin preconditioning protects against myocardial stunning and preserves protein translation in a mouse model of cardiac arrest [PDF]

Journal of Molecular and Cellular Cardiology Plus, 2023
Cardiac arrest (CA) causes high mortality due to multi-system organ damage attributable to ischemia-reperfusion injury. Recent work in our group found that among diabetic patients who experienced cardiac arrest, those taking metformin had less evidence ...
Cody A. Rutledge, Claudia Lagranha, Takuto Chiba, Kevin Redding, Donna B. Stolz, Eric Goetzman, Sunder Sims-Lucas, Brett A. Kaufman   +7 more
doaj   +2 more sources