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Ubiquity of myocardial stunning
Basic Research in Cardiology, 1995The prolonged depression of myocardial function following episodes of myocardial ischemia now known as myocardial stunning, appears ubiquitous in both the experimental and clinical settings. With recent therapies designed to ameliorate ischemic myocardium, e.g., coronary artery bypass, coronary thrombolysis, coronary angioplasty, the inexorable ...
S F, Vatner, G R, Heyndrickx
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Clinical manifestations of myocardial stunning
Coronary Artery Disease, 2001The phenomenon of myocardial stunning has been observed in all animal species studied. The possible occurrence of myocardial stunning in man has been demonstrated after either regional ischemia (such as exercise-induced angina, vasospastic or unstable angina) or after global ischemia (i.e., after cardioplegic arrest during cardiac surgery, or cardiac ...
AMBROSIO, Giuseppe, TRITTO, Isabella
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Clinical relevance of myocardial ?stunning?
Cardiovascular Drugs and Therapy, 1991Experimental studies have demonstrated that myocardium reperfused after reversible ischemia exhibits prolonged depression of contractile function ("stunning"). Despite the multiplicity of clinical situations in which myocardial stunning would be expected to occur, investigation of this phenomenon in humans has been hindered by several major problems ...
R, Bolli, C J, Hartley, R S, Rabinovitz
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Myocardial stunning after cerebral infarction
International Journal of Cardiology, 1997Myocardial stunning has not been described in patients with cerebrovascular accidents. We present a patient in whom inferior wall hypokinesis, ST-segment elevations and Q waves developed after acute right hemisphere ischemic stroke. Total recovery ensued within 5 days. Coronary vasospasm induced by stroke-related sympathetic surge might be the cause of
T D, Wang, C C, Wu, Y T, Lee
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Energy metabolism in myocardial stunning
Journal of Molecular and Cellular Cardiology, 1992We investigated the effect of reversible ischemia, leading to persistent contractile dysfunction (stunning), on myocardial energy metabolism. The balance of energy metabolism is expressed by the phosphorylation state of cytosolic nucleotides. This variable cannot be measured directly because of nucleotide compartmentation, but in the isolated heart it ...
ZUCCHI, RICCARDO +4 more
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Myocardial stunning and hibernation revisited
Nature Reviews Cardiology, 2021Unlike acute myocardial infarction with reperfusion, in which infarct size is the end point reflecting irreversible injury, myocardial stunning and hibernation result from reversible myocardial ischaemia-reperfusion injury, and contractile dysfunction is the obvious end point.
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Current interpretation of myocardial stunning
Trends in Cardiovascular Medicine, 2018Myocardial stunning is a temporary post-ischemic cardiac mechanical dysfunction. As such, it is a heterogeneous entity and different conditions can promote its occurrence. Transient coronary occlusion, increased production of catecholamines and endothelin, and myocardial inflammation are all possible causes of myocardial stunning.
Guaricci, Andrea Igoren +7 more
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Therapy of myocardial stunning
Basic Research in Cardiology, 1997Since in the clinical setting stunning may coexist with persistently ischemic and infarcting myocardium, the ben fit el therapeutic interventions on the stunned myocardium must be weighed against potential deleterious effects on the ischemic myocardium.
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Therapeutic Hyperoxia Diminishes Myocardial Stunning
Journal of Cardiac Surgery, 1994We used a model of isolated coronary perfusion to answer the question: Does high PO2 during low flow myocardial ischemia diminish postischemic myocardial contractile dysfunction? In 12 anesthetized, open chest swine, the left anterior descending (LAD) coronary artery was cannulated and perfused via an extracorporeal circuit. Normoxic arterial blood was
B A, Cason, R F, Hickey, I, Shubayev
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Mitochondrial function in myocardial stunning
Journal of Molecular and Cellular Cardiology, 1991Mitochondrial respiration parameters were studied in mitochondria isolated from normal, ischemic and post-ischemic rabbit hearts. Mitochondrial function was related to tissue content of high energy phosphates (HEP) and cardiac function in the isolated working rabbit heart preparation.
W, Flameng +4 more
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