Results 271 to 280 of about 14,229 (340)

Molecular Mechanism of Caspase‐8–Dependent Interleukin‐18 Activation in Pancreatic Cancer Cells Induced by 5‐Fluorouracil and Nutrient Starvation

open access: yesGenes to Cells, Volume 31, Issue 3, May 2026.
Nutrient starvation triggers pyroptosis with cleavage of pro‐IL‐18 and GSDMD in pancreatic cancer cells, and treatment of 5‐FU enhances this process. As a result, active IL‐18 is released and leads to inflammation. ABSTRACT Interleukin‐18 (IL‐18) is a pro‐inflammatory cytokine, and higher IL‐18 expression in pancreatic tumors is associated with poor ...
Hiroki Kamino   +2 more
wiley   +1 more source

SORBS2: A Molecular Nexus in Multisystem Diseases Through Scaffold‐Mediated Regulation

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Sorbin and SH3 Domain Containing 2 (SORBS2), a multifunctional scaffold protein harbouring Sorbin homology (SoHo) and Src homology 3 (SH3) domains, serves as a molecular hub in human diseases by integrating cytoskeletal remodelling, signal transduction and RNA metabolic regulation. This study systematically analyses SORBS2's molecular features,
Qiwei Jia, Yong Zhang
wiley   +1 more source

Ischaemic preconditioning regulates cardiac transcriptome via DNA methylation conferring cardio-protection from ischaemic reperfusion injury. [PDF]

open access: yesEur Heart J Open
Khan AW   +10 more
europepmc   +1 more source

Research Topics and Trends in MIMIC‐IV: A Large ICU Database Relevant for Critical Care Nursing

open access: yesNursing in Critical Care, Volume 31, Issue 3, May 2026.
ABSTRACT Background The Medical Information Mart for Intensive Care‐IV (MIMIC‐IV) clinical database has become a central resource for data‐driven critical care research, enabling advances in clinical informatics, machine learning and nursing science.
Yuh‐Shan Ho   +5 more
wiley   +1 more source

Myocardial and Neural Damage due to Pulmonary Vein Isolation: Comparison of Pulsed Electric Field and Thermal Ablation

open access: yesPacing and Clinical Electrophysiology, Volume 49, Issue 5, Page 618-625, May 2026.
ABSTRACT Background Pulmonary vein isolation (PVI) using thermal energy—radiofrequency (RF) or cryoablation (CRYO)—is associated with direct myocardial injury and collateral neural damage. In contrast, pulsed electric field (PEF) energy has emerged as a neural‐sparing alternative.
Predrag Stojadinović   +12 more
wiley   +1 more source

Post‐ROSC ST‐Segment Elevation: A Diagnostic Pitfall in Cardiac Arrest Survivors

open access: yes
Annals of Noninvasive Electrocardiology, Volume 31, Issue 3, May 2026.
Oğuz Kaan Kaya
wiley   +1 more source

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