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Myocardial stunning and hibernation revisited
Nature Reviews Cardiology, 2021Unlike acute myocardial infarction with reperfusion, in which infarct size is the end point reflecting irreversible injury, myocardial stunning and hibernation result from reversible myocardial ischaemia-reperfusion injury, and contractile dysfunction is the obvious end point.
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Energy metabolism in myocardial stunning
Journal of Molecular and Cellular Cardiology, 1992We investigated the effect of reversible ischemia, leading to persistent contractile dysfunction (stunning), on myocardial energy metabolism. The balance of energy metabolism is expressed by the phosphorylation state of cytosolic nucleotides. This variable cannot be measured directly because of nucleotide compartmentation, but in the isolated heart it ...
ZUCCHI, RICCARDO +4 more
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Mitochondrial function in myocardial stunning
Journal of Molecular and Cellular Cardiology, 1991Mitochondrial respiration parameters were studied in mitochondria isolated from normal, ischemic and post-ischemic rabbit hearts. Mitochondrial function was related to tissue content of high energy phosphates (HEP) and cardiac function in the isolated working rabbit heart preparation.
W, Flameng +4 more
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Cellular Mechanisms of Myocardial Stunning
Annual Review of Physiology, 1992Stunning describes the impairment of contraction observed in myocardium that has been reperfused after brief periods of ischemia (12, 31, 90). The critical feature of the definition lies in the premise that no permanent injury has occurred; hence, stunning resolves entirely, albeit slowly (hours to days; 12).
H, Kusuoka, E, Marban
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Role of Adenosine in the Treatment of Myocardial Stunning
Cardiovascular Drugs and Therapy, 1991Adenosine is an endogenous nucleoside produced from the breakdown of adenosine triphosphate (ATP) that possesses a number of complex cellular and metabolic effects that could ameliorate postischemic contractile dysfunction (myocardial stunning). Potential mechanisms include the repletion of high-energy phosphate stores, reduced myocardial oxygen ...
M B, Forman, C E, Velasco
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Myocardial “Stunning” and Substrate Metabolism
Journal of Cardiac Surgery, 1994Although many experts have dismissed myocardial substrate metabolism as having a role in the phenomenon known as "myocardial stunning," recent studies using the isolated perfused working rat heart (especially from Lopaschuk's laboratory) have provided evidence that perhaps there is a role for alterations in myocardial substrate metabolism in producing ...
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Myocardial stunning after cerebral infarction
International Journal of Cardiology, 1997Myocardial stunning has not been described in patients with cerebrovascular accidents. We present a patient in whom inferior wall hypokinesis, ST-segment elevations and Q waves developed after acute right hemisphere ischemic stroke. Total recovery ensued within 5 days. Coronary vasospasm induced by stroke-related sympathetic surge might be the cause of
T D, Wang, C C, Wu, Y T, Lee
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Effect of Adenosine on Myocardial ‘Stunning’ in the Dog
Circulation Research, 1995AbstractRecent evidence suggests a cardioprotective effect of adenosine in myocardial ischemia and reperfusion. The present study was undertaken to determine (1) whether adenosine attenuates myocardial stunning, (2) if so, whether the beneficial effect of adenosine takes place during ischemia or after reperfusion, and (3) whether adenosine ...
S, Sekili +5 more
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Mechanisms Underlying Myocardial Stunning
Journal of Cardiac Surgery, 1993The effect of myocardial stunning on mitochondrial function was examined in rabbit hearts. After global normothermic ischemia followed by reperfusion, we previously found that mitochondrial high energy phosphate content was not significantly diminished.
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Oxygen Radicals and Myocardial Stunning
Journal of Cardiac Surgery, 1994There is compelling, although indirect, evidence that oxygen free radicals, generated during ischemia as well as upon reperfusion and reoxygenation of the ischemic heart, contribute to the reversible ventricular dysfunction characterized as myocardial stunning.
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