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Myocardial stunning and hibernation revisited
Nature Reviews Cardiology, 2021Unlike acute myocardial infarction with reperfusion, in which infarct size is the end point reflecting irreversible injury, myocardial stunning and hibernation result from reversible myocardial ischaemia-reperfusion injury, and contractile dysfunction is the obvious end point.
Gerd Heusch
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Current interpretation of myocardial stunning
Trends in Cardiovascular Medicine, 2018Myocardial stunning is a temporary post-ischemic cardiac mechanical dysfunction. As such, it is a heterogeneous entity and different conditions can promote its occurrence. Transient coronary occlusion, increased production of catecholamines and endothelin, and myocardial inflammation are all possible causes of myocardial stunning.
Guaricci, Andrea Igoren +7 more
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Journal of Cardiac Surgery, 1994
Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Myocardial stunning is an unfavorable phenomenon that is manifest during reperfusion and is caused mostly by events associated with reperfusion.
M L, Hess, R C, Kukreja
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Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Myocardial stunning is an unfavorable phenomenon that is manifest during reperfusion and is caused mostly by events associated with reperfusion.
M L, Hess, R C, Kukreja
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Heart Failure Reviews, 2003
Myocardial stunning refers to the contractile dysfunction that occurs following an episode of acute ischaemia, despite the return of normal blood flow. The phenomenon was initially identified in animal models, where it has been very well characterised, and there was initial doubt about whether a similar syndrome occurred in humans, and if it did ...
Edward, Barnes, Masood A, Khan
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Myocardial stunning refers to the contractile dysfunction that occurs following an episode of acute ischaemia, despite the return of normal blood flow. The phenomenon was initially identified in animal models, where it has been very well characterised, and there was initial doubt about whether a similar syndrome occurred in humans, and if it did ...
Edward, Barnes, Masood A, Khan
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Therapy for myocardial stunning
Basic Research in Cardiology, 1995Myocardial stunning, or postischemic dysfunction, is defined as delayed recovery of systolic and/or diastolic function of viable myocardium despite restoration of coronary flow after an ischemic insult (4). The severity and duration of myocardial stunning is highly dependent on the duration and severity of the previous ischemic insult (2).
Y, Birnbaum, R A, Kloner
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Ubiquity of myocardial stunning
Basic Research in Cardiology, 1995The prolonged depression of myocardial function following episodes of myocardial ischemia now known as myocardial stunning, appears ubiquitous in both the experimental and clinical settings. With recent therapies designed to ameliorate ischemic myocardium, e.g., coronary artery bypass, coronary thrombolysis, coronary angioplasty, the inexorable ...
S F, Vatner, G R, Heyndrickx
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Clinical manifestations of myocardial stunning
Coronary Artery Disease, 2001The phenomenon of myocardial stunning has been observed in all animal species studied. The possible occurrence of myocardial stunning in man has been demonstrated after either regional ischemia (such as exercise-induced angina, vasospastic or unstable angina) or after global ischemia (i.e., after cardioplegic arrest during cardiac surgery, or cardiac ...
AMBROSIO, Giuseppe, TRITTO, Isabella
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Clinical relevance of myocardial ?stunning?
Cardiovascular Drugs and Therapy, 1991Experimental studies have demonstrated that myocardium reperfused after reversible ischemia exhibits prolonged depression of contractile function ("stunning"). Despite the multiplicity of clinical situations in which myocardial stunning would be expected to occur, investigation of this phenomenon in humans has been hindered by several major problems ...
R, Bolli, C J, Hartley, R S, Rabinovitz
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