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Independency of myocardial stunning of endothelial stunning?
Basic Research in Cardiology, 2007Vascular endothelial cells play an important role in the control of vascular tone. The reasons for coronary endothelial dysfunction are complex and may involve ischemia/reperfusion injury. We investigated whether endothelial, smooth muscle, and myocardial dysfunction are independent phenomena.Rabbit hearts were rapidly excised without intermittent ...
Valdeci Juarez Pomblum +4 more
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Clinical manifestations of myocardial stunning
Coronary Artery Disease, 2001The phenomenon of myocardial stunning has been observed in all animal species studied. The possible occurrence of myocardial stunning in man has been demonstrated after either regional ischemia (such as exercise-induced angina, vasospastic or unstable angina) or after global ischemia (i.e., after cardioplegic arrest during cardiac surgery, or cardiac ...
AMBROSIO, Giuseppe, TRITTO, Isabella
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Energy metabolism in myocardial stunning
Journal of Molecular and Cellular Cardiology, 1992We investigated the effect of reversible ischemia, leading to persistent contractile dysfunction (stunning), on myocardial energy metabolism. The balance of energy metabolism is expressed by the phosphorylation state of cytosolic nucleotides. This variable cannot be measured directly because of nucleotide compartmentation, but in the isolated heart it ...
ZUCCHI, RICCARDO +4 more
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Current interpretation of myocardial stunning
Trends in Cardiovascular Medicine, 2018Myocardial stunning is a temporary post-ischemic cardiac mechanical dysfunction. As such, it is a heterogeneous entity and different conditions can promote its occurrence. Transient coronary occlusion, increased production of catecholamines and endothelin, and myocardial inflammation are all possible causes of myocardial stunning.
Guaricci, Andrea Igoren +7 more
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Myocardial Stunning: An Overview
Journal of Cardiac Surgery, 1993Over the past two decades, we have challenged the belief that transient ischemia is benign with little functional sequelae following resolution of ischemia. The phenomenon of prolonged postischemic contractile dysfunction, or of myocardial stunning, has been developed and is under investigation using multiple experimental and clinical models ...
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Clinical relevance of myocardial ?stunning?
Cardiovascular Drugs and Therapy, 1991Experimental studies have demonstrated that myocardium reperfused after reversible ischemia exhibits prolonged depression of contractile function ("stunning"). Despite the multiplicity of clinical situations in which myocardial stunning would be expected to occur, investigation of this phenomenon in humans has been hindered by several major problems ...
Craig J. Hartley +2 more
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Myocardial stunning and hibernation revisited
Nature Reviews Cardiology, 2021Unlike acute myocardial infarction with reperfusion, in which infarct size is the end point reflecting irreversible injury, myocardial stunning and hibernation result from reversible myocardial ischaemia-reperfusion injury, and contractile dysfunction is the obvious end point.
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Journal of Cardiac Surgery, 1993
The use of animal models is a valuable approach to the elucidation of the pathophysiology of myocardial stunning. Coronary occlusion followed by reperfusion produces stunning experimentally, mimicking a myocardial infarction followed by thrombolysis, angioplasty, or coronary bypass.
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The use of animal models is a valuable approach to the elucidation of the pathophysiology of myocardial stunning. Coronary occlusion followed by reperfusion produces stunning experimentally, mimicking a myocardial infarction followed by thrombolysis, angioplasty, or coronary bypass.
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Mitochondrial function in myocardial stunning
Journal of Molecular and Cellular Cardiology, 1991Mitochondrial respiration parameters were studied in mitochondria isolated from normal, ischemic and post-ischemic rabbit hearts. Mitochondrial function was related to tissue content of high energy phosphates (HEP) and cardiac function in the isolated working rabbit heart preparation.
M. Mattheussen +4 more
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Cellular Mechanisms of Myocardial Stunning
Annual Review of Physiology, 1992Stunning describes the impairment of contraction observed in myocardium that has been reperfused after brief periods of ischemia (12, 31, 90). The critical feature of the definition lies in the premise that no permanent injury has occurred; hence, stunning resolves entirely, albeit slowly (hours to days; 12).
Eduardo Marbán, Hideo Kusuoka
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