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Therapy for myocardial stunning
Basic Research in Cardiology, 1995Myocardial stunning, or postischemic dysfunction, is defined as delayed recovery of systolic and/or diastolic function of viable myocardium despite restoration of coronary flow after an ischemic insult (4). The severity and duration of myocardial stunning is highly dependent on the duration and severity of the previous ischemic insult (2).
Robert A. Kloner, Y. Birnbaum
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Minerva Cardioangiologica : a Journal on Cardiovascular Pathophysiology, Clinical Medicine and Therapy, 2020
INTRODUCTION The concomitant presence of myocardial necrosis with myocardial ischemia, stunning and hibernation may complicate appraisal of left ventricular (LV) function and patient management.
F. Nudi +6 more
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INTRODUCTION The concomitant presence of myocardial necrosis with myocardial ischemia, stunning and hibernation may complicate appraisal of left ventricular (LV) function and patient management.
F. Nudi +6 more
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Intradialytic exercise preconditioning: an exploratory study on the effect on myocardial stunning.
Nephrology, Dialysis and Transplantation, 2019Background Exercise preconditioning provides immediate protection against cardiac ischemia in clinical/preclinical studies in subjects without chronic kidney disease.
Jarrin D. Penny +6 more
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Therapy of myocardial stunning [PDF]
Basic Research in Cardiology, 1997 Since in the clinical setting stunning may coexist with persistently ischemic and infarcting myocardium, the ben fit el therapeutic interventions on the stunned myocardium must be weighed against potential deleterious effects on the ischemic myocardium.
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Ubiquity of myocardial stunning
Basic Research in Cardiology, 1995The prolonged depression of myocardial function following episodes of myocardial ischemia now known as myocardial stunning, appears ubiquitous in both the experimental and clinical settings. With recent therapies designed to ameliorate ischemic myocardium, e.g., coronary artery bypass, coronary thrombolysis, coronary angioplasty, the inexorable ...
Guy R. Heyndrickx, Stephen F. Vatner
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Independency of myocardial stunning of endothelial stunning?
Basic Research in Cardiology, 2007Vascular endothelial cells play an important role in the control of vascular tone. The reasons for coronary endothelial dysfunction are complex and may involve ischemia/reperfusion injury. We investigated whether endothelial, smooth muscle, and myocardial dysfunction are independent phenomena.Rabbit hearts were rapidly excised without intermittent ...
Valdeci Juarez Pomblum +4 more
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Clinical manifestations of myocardial stunning
Coronary Artery Disease, 2001The phenomenon of myocardial stunning has been observed in all animal species studied. The possible occurrence of myocardial stunning in man has been demonstrated after either regional ischemia (such as exercise-induced angina, vasospastic or unstable angina) or after global ischemia (i.e., after cardioplegic arrest during cardiac surgery, or cardiac ...
AMBROSIO, Giuseppe, TRITTO, Isabella
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Energy metabolism in myocardial stunning
Journal of Molecular and Cellular Cardiology, 1992We investigated the effect of reversible ischemia, leading to persistent contractile dysfunction (stunning), on myocardial energy metabolism. The balance of energy metabolism is expressed by the phosphorylation state of cytosolic nucleotides. This variable cannot be measured directly because of nucleotide compartmentation, but in the isolated heart it ...
ZUCCHI, RICCARDO +4 more
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Myocardial Stunning: An Overview
Journal of Cardiac Surgery, 1993Over the past two decades, we have challenged the belief that transient ischemia is benign with little functional sequelae following resolution of ischemia. The phenomenon of prolonged postischemic contractile dysfunction, or of myocardial stunning, has been developed and is under investigation using multiple experimental and clinical models ...
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Clinical relevance of myocardial ?stunning?
Cardiovascular Drugs and Therapy, 1991Experimental studies have demonstrated that myocardium reperfused after reversible ischemia exhibits prolonged depression of contractile function ("stunning"). Despite the multiplicity of clinical situations in which myocardial stunning would be expected to occur, investigation of this phenomenon in humans has been hindered by several major problems ...
Craig J. Hartley +2 more
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