Results 61 to 70 of about 14,229 (340)

Glucagon-like peptide-1 derived cardioprotection does not utilize a KATP-channel dependent pathway: mechanistic insights from human supply and demand ischemia studies. [PDF]

, 2016
BACKGROUND: Glucagon-like peptide-1 (7-36) amide (GLP-1) protects against stunning and cumulative left ventricular dysfunction in humans. The mechanism remains uncertain but GLP-1 may act by opening mitochondrial K-ATP channels in a similar fashion to ...
Axell, Richard G, Brown, Adam J, Clarke, Sophie J, Dutka, David P, Giblett, Joel P, Hoole, Stephen P, McCormick, Liam, O'Sullivan, Michael, Read, Philip A, Reinhold, Johannes, West, Nick EJ, White, Paul A   +11 more
core   +4 more sources

Temporal Trends and Short‐ and Long‐Term Mortality of People With Acute Myocardial Infarction and Rheumatoid Arthritis: A Nationwide Cohort Study

Arthritis Care &Research, EarlyView.
Objective We investigated whether a diagnosis of rheumatoid arthritis (RA) affects the quality of inpatient acute myocardial infarction (AMI) care and long‐term mortality post‐AMI. Methods We analyzed data from 784,091 adults, 6,047 with a diagnosis of RA, from England and Wales hospitalized with AMI between 2005 and 2019 from the Myocardial Ischaemia ...
Megan Butler, Nicholas Weight, Muhammad Rashid, Rodrigo Bagur, Purvi Parwani, Samantha Hider, Edward Roddy, Robert Butler, Mamas A. Mamas   +8 more
wiley   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Analysis of ischaemic crisis using the informational causal entropy-complexity plane [PDF]

, 2018
In the present work, an ischaemic process, mainly focused on the reperfusion stage, is studied using the informational causal entropy-complexity plane.
Francisco O. Redelico, Francisco Traversaro, Leandro J. Cymberknop, Miura M., Osvaldo A. Rosso, Rashed E., Ricardo L. Armentano, Rosso O. A., Walter Legnani   +8 more
core   +1 more source

Myocardial stunning associated with a myocardial bridge [PDF]

International Journal of Cardiology, 2002
A myocardial bridge is a discrete systolic constricnormal and tests for viral infections screened negation of a coronary artery, most commonly the left tive. She received oral aspirin (100 mg daily) and anterior descending, caused by some myocardial propranolol (20 mg t.i.d.) and remained asymptomattissue ‘bridging’ the vessel [1]. Regarded for long ic
MARCHIONNI, NICCOLO', M. FALAI, M. MARGHERI, FUMAGALLI, STEFANO, T. CHECHI   +4 more
openaire   +3 more sources

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Significant Improvement in Severely Stunned Left Ventricle after Percutaneous Coronary Intervention [PDF]

Journal of Tehran University Heart Center, 2008
This is a case of severely stunned left ventricle which occurred after a non-ST elevation myocardial infarction in a 76-year-old woman who was a known case of three-vessel disease. Her symptoms and cardiac function responded well to revascularization.
Gholamreza Davoodi, Hakime Sadeghian, Ahmad Yamini Sharif, Seyed Ebrahim Kassaian, Ahmad Sharafi, Abbas Soleimani   +5 more
doaj   +2 more sources

Intradialytic cardiac magnetic resonance imaging to assess cardiovascular responses in a short-term trial of hemodiafiltration and hemodialysis [PDF]

, 2016
Hemodynamic stress during hemodialysis (HD) results in recurrent segmental ischemic injury (myocardial stunning) that drives cumulative cardiac damage.
Buchanan, Charlotte, Canaud, Bernard, Cox, Eleanor, Francis, Susan T., Köhler, Katrin, McIntyre, Christopher W., Mohammed, Azharuddin, Selby, Nicholas Michael, Taal, Maarten W.   +8 more
core   +3 more sources

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Safety and feasibility of hyperkalemic cardioplegia with diazoxide in cardiac surgery: The Cardioplegia with Diazoxide in Cardiac Surgery TrialCentral MessagePerspective

JTCVS Open
Background: We have demonstrated cardioprotection by the adenosine triphosphate–sensitive potassium (KATP) channel opener diazoxide in multiple animal models in an effort to reduce myocardial stunning following cardiac surgery.
AlleaBelle Bradshaw, MD, Jessica B. Briscoe, MD, Lisa Fornaresio, PhD, Zyriah Robinson, BS, Michelle Carvajal Villalba, MD, Shivani Shirodkar, MBBS, MPH, Hamza Aziz, MD, Jennifer S. Lawton, MD   +7 more
doaj   +1 more source