Results 71 to 80 of about 136,887 (323)
Advanced Science, EarlyView.Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang +18 more
wiley +1 more source
SARS-CoV-2: a potential novel etiology of fulminant myocarditis
Herz, 2020 Coronaviruses are enveloped nonsegmented positive-sense RNA viruses, which are broadly distributed in humans and other mammals, including camels, bats, masked palm civets, mice, dogs, and cats [1].
Chen Chen, Yiwu Zhou, Daowen Wang
semanticscholar +1 more source
Circulation, 2022 Background: Immune checkpoint inhibitors (ICIs) are monoclonal antibodies used to activate the immune system against tumor cells. Despite therapeutic benefits, ICIs have the potential to cause immune-related adverse events such as myocarditis, a rare but
Han Zhu +16 more
semanticscholar +1 more source
International Journal of Cardiology, 1996 We have developed two models of myocarditis in mice. The first is produced by infection with Coxsackievirus B3; the second results from immunization with cardiac myosin. Both forms of myocarditis occur in the same genetically predisposed strains. Genetically resistant mice can be rendered susceptible to myocarditis by co-treatment with cytokines IL-1 ...
N R, Rose, S L, Hill
openaire +2 more sources
Myocarditis and inflammatory cardiomyopathy: from diagnosis to treatment
Türk Kardiyoloji Derneği Arşivi, 2015 Based on the definition in the European Society of Cardiology statement, myocarditis is an inflammatory disease of the myocardium diagnosed by established histological, immunological, and immunohistochemical criteria, whereas inflammatory cardiomyopathy ...
Felicitas Escher +3 more
doaj +1 more source
Advanced Science, EarlyView.This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang +12 more
wiley +1 more source
Reviewing the current diagnostic and treatment approaches for myocarditis – analysis of literature
Quality in SportIntroduction: Myocarditis is an inflammatory disease of the heart muscle, presenting with symptoms ranging from mild discomfort to severe cardiac dysfunction.
Damian Zys +9 more
doaj +1 more source
Advanced Science, EarlyView.This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu +6 more
wiley +1 more source
Nature CommunicationsImmune checkpoint inhibitor (ICI)-induced myocarditis involves intensive immune/inflammation activation; however, its molecular basis is unclear.
Si-Jia Sun +17 more
semanticscholar +1 more source
JAMA Network Open, 2022 This cohort study estimates rates of myocarditis and pericarditis after receipt of an mRNA COVID-19 vaccine among individuals in Ontario, Canada, stratified by recipients’ age and sex and by the vaccine product, schedule, and interdose interval.
S. Buchan +10 more
semanticscholar +1 more source