Results 31 to 40 of about 206,512 (311)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Specific Inhibition of CYP4A Alleviates Myocardial Oxidative Stress and Apoptosis Induced by Advanced Glycation End-Products

Frontiers in Pharmacology, 2019
High exposure to advanced glycation end-products (AGEs) may induce cardiotoxicity. However, the effects and mechanisms remain to be further clarified.
Rui Wang, Rui Wang, Li Wang, Jinlong He, Shanshan Li, Xiaojing Yang, Pengyuan Sun, Yuhui Yuan, Jinyong Peng, Jinsong Yan, Jianling Du, Hua Li   +11 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

ShengMai-San Attenuates Cardiac Remodeling in Diabetic Rats by Inhibiting NOX-Mediated Oxidative Stress

Diabetes, Metabolic Syndrome and Obesity, 2021
Yanting Lu, Shu Zhu, Xiaoyan Wang, Juhai Liu, Yingying Li, Wei Wang, Shijun Wang, Furong Wang College of TCM, Shandong University of Traditional Chinese Medicine, Jinan, 250355, People’s Republic of ChinaCorrespondence: Shijun Wang; Furong Wang ...
Lu Y, Zhu S, Wang X, Liu J, Li Y, Wang W, Wang S, Wang F   +7 more
doaj  

Gender characteristics of retinal parameters in patients with uncomplicated hypertension

Кардиоваскулярная терапия и профилактика, 2020
Aim. To establish gender specificities of retinal arteriolar and venular diameters, foveal avascular zone (FAZ) area, subfoveal choroid thickness (SCT), and to determine their association with cardiovascular risk and prognosis in patients with ...
A. V. Barsukov, K. A. Shcherbakova, M. A. Burnasheva, D. S. Maltsev, A. N. Kulikov, A. E. Korovin, M. V. Yasenovets, A. V. Gordienko   +7 more
doaj   +1 more source

Graft preservation confers myocardial protection during coronary artery bypass grafting

Frontiers in Cardiovascular Medicine, 2022
BackgroundDuring on-pump coronary artery bypass grafting (ONCAB), graft flushing for distal anastomoses testing also perfuses the downstream myocardium.
Philipp Szalkiewicz, Maximilian Y. Emmert, Maximilian Y. Emmert, Paul P. Heinisch, Zsuzsanna Arnold, Zsuzsanna Arnold, Ingo Crailsheim, Ingo Crailsheim, Markus Mach, Markus Mach, Thomas Aschacher, Thomas Aschacher, Thomas Aschacher, Martin Grabenwöger, Martin Grabenwöger, Martin Grabenwöger, Bernhard Winkler, Bernhard Winkler, Bernhard Winkler   +18 more
doaj   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Hibernating Myocardium [PDF]

Circulation Research, 2002
In the early 1980s, Rahimtoola1 reviewed the results of coronary bypass surgery trials and identified patients with coronary artery disease and chronic left ventricular dysfunction that improved upon revascularization. He proposed the concept of hibernating myocardium as “prolonged ischemia… in which myocardial metabolism and ventricular function are ...
Gerd Heusch, Rainer Schulz
openaire   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source