Results 131 to 140 of about 180,856 (396)
Advanced Science, EarlyView.Cyclic stretching of fibroblasts triggers coordinated nuclear mechanosensing events, including calcium ion release, perinuclear actin assembly, emerin translocation, and H3K9me3 loss, increasing chromatin accessibility for specific genes related to mechanotransduction and repair.
Hye‐Won Shim +10 more
wiley +1 more source
Altered excitation-contraction coupling in human chronic atrial fibrillation [PDF]
, 2012 This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory ...
Grandi, E., Pandit, S.V., Workman, A.J.
core +1 more source
Advanced Science, EarlyView.An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu +11 more
wiley +1 more source
β-adrenergic-mediated dynamic augmentation of sarcolemmal CaV 1.2 clustering and co-operativity in ventricular myocytes. [PDF]
, 2019 Key pointsPrevailing dogma holds that activation of the β-adrenergic receptor/cAMP/protein kinase A signalling pathway leads to enhanced L-type CaV 1.2 channel activity, resulting in increased Ca2+ influx into ventricular myocytes and a positive ...
Del Villar, Silvia G +8 more
core +1 more source
Advanced Science, EarlyView.The TMEM43 ‐ P386S mutation causes arrhythmogenic right ventricular cardiomyopathy (ARVC) by mislocalizing itself from nuclear envelope (NE) to cytoplasm, disrupting lamin B2 (a novel TMEM43 interactor) localization, NE integrity and chromatin accessibility, causing hyper ‐ phosphorylation and reduced expression/clustering of ryanodine receptor type 2 (
Jiaxi Shen +23 more
wiley +1 more source
JACC: Basic to Translational Science, 2019 Summary: Swine subjected to 2 weeks of repetitive pressure overload (RPO) exhibited significant myocyte loss, but left ventricular (LV) systolic function was preserved, and chamber dilatation did not occur. Instead, myocardial remodeling characterized by
Brian R. Weil, PhD +4 more
doaj +1 more source
Advanced Science, EarlyView.USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna +11 more
wiley +1 more source
Cardiac myocyte apoptosis [PDF]
European Heart Journal, 1999 S A Cook, P. A. Poole-Wilson
openaire +3 more sources
Advanced Science, EarlyView.A multifunctional and water‐soluble conductive nanocomposite is fabricated by employing tannic acid‐modified MXene as a template to direct the in situ polymerization of poly(3,4‐ethylenedioxythiophene) (PEDOT). The resulting PEDOT nanosheets are uniformly integrated into hydrogel networks, simultaneously imparting stretchability (>800%), strong tissue ...
Huiqi Sun +7 more
wiley +1 more source
Current Developments and Challenges in the Field of Biohybrid Neural Interfaces—A Scoping Review
Advanced Electronic Materials, EarlyView.This scoping review explores recent advancements and persistent challenges in biohybrid neural interfaces, which integrate living cells with electronic devices to improve neural communication and implant biocompatibility. The article highlights key innovations, methodological diversity, and translational barriers, providing a comprehensive synthesis ...
Yi‐Lin Yu +6 more
wiley +1 more source