Results 51 to 60 of about 124,243 (355)

Cardiogenic and Myogenic Gene Expression in Mesenchymal Stem Cells After 5-Azacytidine Treatment

Turkish Journal of Hematology, 2013
OBJECTIVE: 5-Azacytidine is a hypomethylating agent that is used for the treatment of myelodysplastic syndrome. This histone modifier is widely employed and plays a nonspecific role in influencing the differentiation capability of stem cells. The ability
Aungkura Supokawej, Pakpoom Kheolamai, Kuneerat Nartprayut, Yaowalak U-pratya, Sirikul Manochantr, Methichit Chayosumrit, Surapol Issaragrisil   +6 more
doaj   +1 more source

IL-33 attenuates anoxia/reoxygenation-induced cardiomyocyte apoptosis by inhibition of PKCβ/JNK pathway. [PDF]

PLoS ONE, 2013
Interleukin-33 (IL-33) is a new member of the IL-1 cytokine family. The objectives of present study are to assess whether IL-33 can protect cardiomyocytes from anoxia/reoxygenation (A/R)-induced injury and the mechanism involved in the protection ...
Tao Rui, Qizhu Tang
doaj   +1 more source

Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy [PDF]

, 2014
Chronic neurohormonal and mechanical stresses are central fea-tures of heart disease. Increasing evidence supports a role forthe transient receptor potential canonical channels TRPC3 andTRPC6 in this pathophysiology.
Andersen, Asger, Birnbaumer, Lutz, Jo, Su-Hyun, Kass, David A., Lee, Dong-ik, Lepore, John J., Liu, Ting, Marino, Joseph P., Rainer, Peter P., Schnackenberg, Christine G., Seo, Kinya, Shalkey Hahn, Virginia, Willette, Robert N., Xu, Xiaoping   +13 more
core   +1 more source

EFFECT OF SEVOFLURANE EXPOSURE ON ADRIAMYCIN-INDUCED INJURIES TO MYOCYTES

Российский кардиологический журнал, 2014
The study is to investigate the potential protective effect of sevoflurane on adriamycin induced myocyte injury. We prepared primary myocyte culture from neonatal rats and subjected the cells to adriamycin treatment.
Li-hua Fan, Xin Han, Qing-quan Lian, Jun Li, Hou-xing Lei, NIing Zhang, Xiang-dong Xu, Xiang-hong Lu   +7 more
doaj   +1 more source

A modeling framework for contact, adhesion and mechano-transduction between excitable deformable cells

, 2017
Cardiac myocytes are the fundamental cells composing the heart muscle. The propagation of electric signals and chemical quantities through them is responsible for their nonlinear contraction and dilatation. In this study, a theoretical model and a finite
Gizzi, Alessio, Lenarda, Pietro, Paggi, Marco   +2 more
core   +1 more source

Biohybrid Soft Robots Powered by Myocyte: Current Progress and Future Perspectives

Micromachines, 2023
Myocyte-driven robots, a type of biological actuator that combines myocytes with abiotic systems, have gained significant attention due to their high energy efficiency, sensitivity, biocompatibility, and self-healing capabilities.
Zheng Yuan, Qinghao Guo, Delu Jin, Peifan Zhang, Wenguang Yang   +4 more
doaj   +1 more source

Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. [PDF]

, 2005
BACKGROUND: Electrophysiological data suggest that cardiac KATP channels consist of Kir6.2 and SUR2A subunits, but the distribution of these (and other KATP channel subunits) is poorly defined.
Artman, M, Coetzee, WA, Dhar Chowdhury, P, Giblin, JP, Han, S, Lanning, J, Lopez, G, Morrissey, A, Nakamura, TY, Parachuru, L, Rosner, E, Tinker, A, Tong, X, Yoshida, H   +13 more
core   +3 more sources

Mst1 inhibition rescues β1-adrenergic cardiomyopathy by reducing myocyte necrosis and non-myocyte apoptosis rather than myocyte apoptosis [PDF]

Basic Research in Cardiology, 2015
It is generally held that inhibition of mammalian sterile 20-like kinase 1 (Mst1) protects the heart through reducing myocyte apoptosis. We determined whether inhibition with a dominant-negative Mst1 (DN-Mst1) would protect against the cardiomyopathy induced by chronic β1-adrenergic receptor (β1-AR) stimulation by preventing myocyte apoptosis.
Grace J, Lee, Lin, Yan, Dorothy E, Vatner, Stephen F, Vatner   +3 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source