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Caveolae and the cardiac myocyte [PDF]
Current Opinion in Physiology, 2018 Caveolae, invaginated lipid rafts, orchestrate signalling in the cardiac myocyte. Here we highlight advances in the field which are relevant to the role of caveolae in these cells. Recent analysis of the molecular organisation and structure of the coat complex, which lines the internal surface of caveolae, suggest a stable inner caveolin layer covered ...
Norman, R, Fuller, W, Calaghan, S
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Nuclear Calcium in Cardiac Myocytes [PDF]
Journal of Cardiovascular Pharmacology, 2015 Calcium (Ca) is a universal second messenger involved in the regulation of various cellular processes, including electrical signaling, contraction, secretion, memory, gene transcription, and cell death. In heart, Ca governs cardiomyocyte contraction, is central in electrophysiological properties, and controls major signaling pathway implicated in gene ...
Ljubojevic, Senka, Bers, Donald M
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Calcium Signaling in Cardiac Myocytes [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 Calcium (Ca(2+)) is a critical regulator of cardiac myocyte function. Principally, Ca(2+) is the link between the electrical signals that pervade the heart and contraction of the myocytes to propel blood. In addition, Ca(2+) controls numerous other myocyte activities, including gene transcription.
Fearnley, Claire J. +2 more
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Hamartomas of mature cardiac myocytes [PDF]
European Heart Journal - Cardiovascular Imaging, 2008 We present two paediatric cases of a very rare, pathologically benign, and primary cardiac tumour composed of mature cardiac myocytes with disorganized cytoarchitecture called hamartoma of mature cardiac myocyte. The patients are usually asymptomatic, may have non-specific electrocardiogram findings, and rarely have associated sudden death.
Allison K. Cabalka +3 more
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Cardiac Myocyte Exosome Isolation [PDF]
, 2016 Exosomes are cell-derived small extracellular membrane vesicles (50-100 nm in diameter) actively secreted by a number of healthy and diseased cell types. Exosomes can mediate cellular, tissue, and organ level micro communication under normal and pathological conditions by shuttling proteins, mRNA, and microRNAs.
Malik, Zulfiqar A +2 more
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Cardiac Myocytes and Mechanosensation [PDF]
, 2012 Mechanosensation is a fundamental process in biology and may have been developed by the early cells in response to hypo-osmotic stress [1]. With the evolution of different cell types and the appearance of multi-cellular organisms the mechanisms of mechanosensation and the corresponding transmission of signals became more complex and evolved in ...
Byambajav Buyandelger, Ralph Knöll
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Mitochondria Dynamics in Cardiac Myocytes [PDF]
Biophysical Journal, 2009 Mitochondrial dynamics are driven by the inner mitochondrial membrane potential, and have significant implications in cell function. Fission and fusion are well established characteristics of mitochondrial dynamics in most cell types. These movements are believed to be geared toward optimizing energy delivery to metabolic sites within the cell.
Mariusz Karbowsky +3 more
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Redox signaling in cardiac myocytes
Free Radical Biology and Medicine, 2011 The heart has complex mechanisms that facilitate the maintenance of an oxygen supply-demand balance necessary for its contractile function in response to physiological fluctuations in workload as well as in response to chronic stresses such as hypoxia, ischemia, and overload.
Xavier Da Costa Dos Santos, Celio Santos +4 more
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Polyploidization of transplanted cardiac myocytes [PDF]
Cell Differentiation and Development, 1988 Pieces of cardiac ventricular tissue of late embryonic or 1-day postnatal rats, implanted beneath the kidney capsule of adult syngeneic hosts, formed viable, beating transplants. These transplants were investigated over a 40-day postoperative course. In the transplants, cellular binucleation and nuclear polyploidization occurred according to the same ...
Brodsky, V. Ya. +3 more
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Cell Death in the Cardiac Myocyte
Biological & Pharmaceutical Bulletin, 2015 Loss of cardiac myocytes plays a critical role in the pathogenesis of cardiovascular disorders. A decrease in the number of cardiac myocytes in cardiac diseases results in sustained, irreversible contractile failure of myocardium. Therefore prevention of cardiac cell death is a potential therapeutic strategy for various heart diseases.
Tetsuro Marunouchi, Kouichi Tanonaka
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