Results 181 to 190 of about 141,107 (310)

The mechanism of action of digoxin requires the sodium-dependent inactivation of the sodium-calcium exchanger. [PDF]

Sci Adv
Scranton K, John S, Angelini M, Zhang R, Schwingshackl A, Goldhaber JI, Olcese R, Ottolia M.   +7 more
europepmc   +1 more source

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

The Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun‐Hee Woo   +6 more
wiley   +1 more source

Dysferlin stabilizes membrane nanodomains of cardiomyocytes after myocardial infarction. [PDF]

Sci Rep
Wegener JB, Zühlke Y, Fleischhacker C, Marks J, Foo B, Bader N, Riedemann GC, Wedemeyer J, Vu KC, Vergel Leon AM, Paulke NJ, Kohl T, Urlaub H, Schmidt C, Hasenfuß G, Moser T, Rog-Zielinska EA, Lenz C, Lehnart SE, Brandenburg S.   +19 more
europepmc   +1 more source

Hyperglycaemia‐induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals

The Journal of Physiology, EarlyView.
Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu, Maria J. Baier, Risto‐Pekka Polonen, Zhandi Liao, Jody L. Martin, Kenneth S. Ginsburg, Julian Mustroph, Donald M. Bers   +7 more
wiley   +1 more source

Rethinking natriuretic peptides: hypoxia and haemoconcentration in atrial fibrillation. [PDF]

Heart
Arjamaa O.
europepmc   +1 more source

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source

PIEZO Force Sensors and the Heart. [PDF]

Cold Spring Harb Perspect Biol
McGrane A, Murray M, Bartoli F, Giannoudi M, Conning-Rowland M, Stewart L, Levelt E, Cubbon RM, Dall'Armellina E, Griffin KJ, Herum KM, Smith AJ, Beech DJ.   +12 more
europepmc   +1 more source

TRPM7 Deficiency Protects Against Myocardial Ischemia-Reperfusion Injury by Regulating Intracellular Zn²⁺ Homeostasis. [PDF]

Circulation
Li X, Li X, Li CX, Feng J, Yue Z, Yan J, Matsushita M, Qyang Y, Runnels LW, Ai X, Yue L.   +10 more
europepmc   +1 more source

Electrophysiological characterization of pre‐adolescents born with intrauterine growth restriction: insights from clinical and computational data

The Journal of Physiology, EarlyView.
Abstract figure legend Depolarization and repolarization duration analysis was conducted in preadolescent groups with IUGR and controls using a 12‐lead ECG. Principal component analysis was applied over the 12‐lead ECGs to generate spatially transformed leads better suited for robust ECG fiducial points detection.
Freddy L. Bueno‐Palomeque, Ernesto Zacur, Esther Pueyo, Fàtima Crispi, Pablo Laguna, Ana Mincholé   +5 more
wiley   +1 more source

The mechanism of electrical remodeling in atrial fibrillation and current research status of natural drugs and active ingredients inhibiting atrial electrical remodeling. [PDF]

Front Cardiovasc Med
Huang X, Wang C, Wang Y, Yang S, Du L, Li L, Wang T, Lu Y.   +7 more
europepmc   +1 more source