Results 11 to 20 of about 141,107 (310)

Down-regulation of replication factor C-40 (RFC40) causes chromosomal missegregation in neonatal and hypertrophic adult rat cardiac myocytes. [PDF]

PLoS ONE, 2012
BACKGROUND: Adult mammalian cardiac myocytes are generally assumed to be terminally differentiated; nonetheless, a small fraction of cardiac myocytes have been shown to replicate during ventricular remodeling.
Hirotaka Ata, Deepa Shrestha, Masahiko Oka, Rikuo Ochi, Chian Ju Jong, Sarah Gebb, John Benjamin, Stephen Schaffer, Holly H Hobart, James Downey, Ivan McMurtry, Rakhee Gupte   +11 more
doaj   +1 more source

Innate immune signaling in hearts and buccal mucosa cells of patients with arrhythmogenic cardiomyopathy

Heart Rhythm O2, 2023
Background: Nuclear factor κB (NF-κB) signaling in cardiac myocytes causes disease in a mouse model of arrhythmogenic cardiomyopathy (ACM) by mobilizing CCR2-expressing macrophages that promote myocardial injury and arrhythmias.
Carlos Bueno-Beti, PhD, Alessandro Tafuni, MD, Stephen P. Chelko, PhD, FHRS, Mary N. Sheppard, MD, Ella Field, MSc, Jennifer Tollit, MSc, Imogen K. Heenan, BSc, Annabelle Barnes, BSc, Matthew R. Taylor, MD, PhD, Luisa Mestroni, MD, Juan Pablo Kaski, MD, Jeffrey E. Saffitz, MD, PhD, FHRS, Angeliki Asimaki, PhD   +12 more
doaj   +1 more source

Myocardial Mitochondrial DNA Drives Macrophage Inflammatory Response through STING Signaling in Coxsackievirus B3-Induced Viral Myocarditis

Cells, 2023
Coxsackievirus B3 (CVB3), a single-stranded positive RNA virus, primarily infects cardiac myocytes and is a major causative pathogen for viral myocarditis (VMC), driving cardiac inflammation and organ dysfunction.
Andong Qin, Zhenke Wen, Sidong Xiong
doaj   +1 more source

Junctional sarcoplasmic reticulum motility in adult mouse ventricular myocytes. [PDF]

, 2020
Excitation-contraction (EC) coupling is the coordinated process by which an action potential triggers cardiac myocyte contraction. EC coupling is initiated in dyads where the junctional sarcoplasmic reticulum (jSR) is in tight proximity to the sarcolemma
de la Mata, Ana, Drum, Benjamin M, Grainger, Nathan, Grainger, Nathan, Santana, L Fernando, Yuan, Can   +5 more
core   +2 more sources

Epigenetic regulation of cardiac myocyte differentiation† [PDF]

Frontiers in Genetics, 2014
Cardiac myocytes (CMs) proliferate robustly during fetal life but withdraw permanently from the cell cycle soon after birth and undergo terminal differentiation. This cell cycle exit is associated with the upregulation of a host of adult cardiac-specific genes.
Oyama, Kyohei, El-Nachef, Danny, Zhang, Yiqiang, Sdek, Patima, MacLellan, W. Robb   +4 more
openaire   +3 more sources

A Comorbidity Model of Myocardial Ischemia/Reperfusion Injury and Hypercholesterolemia in Rat Cardiac Myocyte Cultures

Frontiers in Physiology, 2020
IntroductionThe use of comorbidity models is crucial in cardioprotective drug development. Hypercholesterolemia causes endothelial and myocardial dysfunction, as well as aggravates ischemia/reperfusion (I/R)-induced myocardial injury.
András Makkos, Ágnes Szántai, János Pálóczi, Judit Pipis, Bernadett Kiss, Bernadett Kiss, Paola Poggi, Péter Ferdinandy, Péter Ferdinandy, Péter Ferdinandy, Alexandros Chatgilialoglu, Anikó Görbe, Anikó Görbe, Anikó Görbe   +13 more
doaj   +1 more source

High-Sensitive Cardiospecific Troponins: The Role of Gender-Specific Concentration in the Diagnosis of Acute Coronary Syndrome (Descriptive Review)

Reviews in Cardiovascular Medicine, 2023
Cardiospecific troponins are specifically localized in the troponin-tropomyosin complex and in the cytoplasm of cardiac myocytes. Cardiospecific troponin molecules are released from cardiac myocytes upon their death (irreversible damage in acute coronary
Aleksey Chaulin
doaj   +1 more source

Comprehensive Expression Analysis of Cardiac Fibroblast Growth Factor 23 in Health and Pressure-induced Cardiac Hypertrophy

Frontiers in Cell and Developmental Biology, 2022
Enhanced fibroblast growth factor 23 (FGF23) is associated with left ventricular hypertrophy (LVH) in patients with chronic kidney and heart disease. Experimentally, FGF23 directly induces cardiac hypertrophy and vice versa cardiac hypertrophy stimulates
Fiona Eitner, Beatrice Richter, Saskia Schwänen, Malgorzata Szaroszyk, Isabel Vogt, Andrea Grund, Thomas Thum, Joerg Heineke, Joerg Heineke, Dieter Haffner, Maren Leifheit-Nestler   +10 more
doaj   +1 more source

Hamartomas of mature cardiac myocytes [PDF]

European Heart Journal - Cardiovascular Imaging, 2008
We present two paediatric cases of a very rare, pathologically benign, and primary cardiac tumour composed of mature cardiac myocytes with disorganized cytoarchitecture called hamartoma of mature cardiac myocyte. The patients are usually asymptomatic, may have non-specific electrocardiogram findings, and rarely have associated sudden death.
Shaji C, Menon, Dylan V, Miller, Allison K, Cabalka, Donald J, Hagler   +3 more
openaire   +2 more sources

Identification and characterization of insulin-like growth factor receptors on adult rat cardiac myocytes: linkage to inositol 1,4,5-trisphosphate formation. [PDF]

, 1992
Cultured cardiac myocytes from adult Sprague-Dawley rats express both insulin-like growth factor-I (IGF-I) receptors and insulin-like growth factor-II/mannose 6-phosphate (IGF-II/Man6P) receptors and respond to IGF-I with a dose-dependent accumulation of
Berg, Ingeborg, Funk, Barbara, Gercken, Günther, Guse, Andreas H., Kessler, Ulrike, Kiess, Wieland   +5 more
core   +1 more source