Results 241 to 250 of about 144,200 (309)

Microtubule-Dependent Ca²⁺ Spark Recruitment in the Heart. [PDF]

J Am Heart Assoc
Zhao G, Lederer WJ.
europepmc   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Abnormal Ca²⁺ handling and reduced I_to contribute to citalopram-induced QT prolongation and cardiac arrhythmias. [PDF]

Front Pharmacol
Li Y, Xie J, Zheng Y, Li J, Zhao M, Liu L, Shen H, Lei M, Tan X, Xiao J, Liu X, Chen T.   +11 more
europepmc   +1 more source

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source

Effect of aerobic exercise on the susceptibility of atrial fibrillation among aged mice. [PDF]

J Thorac Dis
Zhao C, Wang Z, Zhao Y, Pang PYK, Rufa M, Feickert S, Ye Q, Liu K, Gu J, Sun J, Wang J.   +10 more
europepmc   +1 more source

A model of β‐adrenergic stimulation in human ventricular cells for tissue‐scale simulations of sympathetically modulated tachycardias

The Journal of Physiology, EarlyView.
Abstract figure legend Modelling β‐adrenergic stimulation in sympathetically remodelled ventricular substrates. Myocardial infarction could result in sympathetic remodelling in ventricular tissues, which affects arrhythmia dynamics. However sympathetic remodelling is challenging to control experimentally; therefore we created an ionic model that ...
Kelly Zhang, Karl Magtibay, Natalia Trayanova, Edward Vigmond   +3 more
wiley   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Impairment of mitochondrial quality control exacerbates diabetes-related atrial fibrillation by cGAS-STING signaling pathway and cardiomyocyte-macrophage crosstalk. [PDF]

Theranostics
Meng S, Duan J, Zhao J, Zhou Z, Sun B, Xu Y, Huang T, Hong T, Chen X, Su T, Yu L, Wang H.   +11 more
europepmc   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Targeting mitochondria to protect the heart: a matter of balance? [PDF]

Clin Sci (Lond)
Zouein FA, Booz GW.
europepmc   +1 more source