The Hippo pathway regulates density-dependent proliferation of iPSC-derived cardiac myocytes
Scientific Reports, 2021 Inducing cardiac myocytes to proliferate is considered a potential therapy to target heart disease, however, modulating cardiac myocyte proliferation has proven to be a technical challenge.
Abigail C. Neininger +3 more
doaj +1 more source
Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin-Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia [PDF]
, 2018 Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial arrhythmogenic syndrome characterized by sudden death. There are several genetic forms of CPVT associated with mutations in genes encoding the cardiac ryanodine receptor (RyR2 ...
Belevych, Andriy E +12 more
core +1 more source
Polyploidization of transplanted cardiac myocytes [PDF]
Cell Differentiation and Development, 1988 Pieces of cardiac ventricular tissue of late embryonic or 1-day postnatal rats, implanted beneath the kidney capsule of adult syngeneic hosts, formed viable, beating transplants. These transplants were investigated over a 40-day postoperative course. In the transplants, cellular binucleation and nuclear polyploidization occurred according to the same ...
Brodsky, V. Ya. +3 more
openaire +3 more sources
Journal of Pharmacological Sciences, 2008 It has been suggested that a new type of large-conductance Ca2+-activated K+ (BK) channel is distributed in the inner mitochondrial membrane (mitoKCa channel) and that its opening may attenuate ischemic cardiac injury.
Kazuho Sakamoto +3 more
doaj +1 more source
Gender differences in cardiac left ventricular mass and function: clinical and experimental observations [PDF]
, 2014 Background: The aim of this study was to evaluate gender-associated impact on left ventricular mass (LVM) and on left ventricular function (LVF) in humans and rats with aging. Methods: Myocyte area and collagen volume fraction (CVF) were studied in rats.
Aiello, Ernesto Alejandro +5 more
core +2 more sources
Cellular Physiology of Rat Cardiac Myocytes in Cardiac Fibrosis: In Vitro Simulation Using the Cardiac Myocyte/Cardiac Non-Myocyte Co-Culture System [PDF]
Hypertension Research, 2008 An understanding of the cellular physiology of cardiac myocytes (MCs) and non-myocytes (NMCs) may help to explain the mechanisms underlying cardiac hypertrophy. Despite numerous studies using MC/NMC co-culture systems, it is difficult to precisely evaluate the influence of each cell type because of the inherent cellular heterogeneity of such a system ...
Keiichi, Ikeda +9 more
openaire +2 more sources
Alexandria Journal of Medicine, 2016 The calcium signaling plays a crucial role in expansion and contraction of cardiac myocytes. This calcium signaling is achieved by calcium diffusion, buffering mechanisms and influx in cardiac myocytes.
Kunal Pathak, Neeru Adlakha
doaj +1 more source
The Unmasking Effect: Propofol-Induced Brugada Pattern in a Critically Ill Patient
Case Reports in Cardiology, 2022 Brugada syndrome is a known cause of dysrhythmias and sudden cardiac death. It is linked to mutations in myocardial sodium channel leading to hyperexcitable cardiac myocytes.
Esiemoghie Akhigbe +4 more
doaj +1 more source
Frequency-dependent signaling in cardiac myocytes
Frontiers in Physiology, 2022 Background: Recent experimental data support the view that signaling activity at the membrane depends on its geometric parameters such as surface area and curvature.
Payam Haftbaradaran Esfahani +4 more
doaj +1 more source
The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis [PDF]
, 2019 Aims: Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the mechanistic links between these risk variants and underlying electrophysiological alterations hampers ...
Benítez Iglesias, Raúl +9 more
core +2 more sources