Results 41 to 50 of about 144,200 (309)
Frequency-dependent signaling in cardiac myocytes
Frontiers in Physiology, 2022 Background: Recent experimental data support the view that signaling activity at the membrane depends on its geometric parameters such as surface area and curvature.
Payam Haftbaradaran Esfahani +4 more
doaj +1 more source
Antioxidants, 2021 To investigate the role of NLRP3 inflammasome in cardiac aging, we evaluate here morphological and ultrastructural age-related changes of cardiac muscles fibers in wild-type and NLRP3-knockout mice, as well as studying the beneficial effect of melatonin ...
Ramy K. A. Sayed +9 more
doaj +1 more source
Modeling effects of L-type ca(2+) current and na(+)-ca(2+) exchanger on ca(2+) trigger flux in rabbit myocytes with realistic T-tubule geometries. [PDF]
, 2012 The transverse tubular system of rabbit ventricular myocytes consists of cell membrane invaginations (t-tubules) that are essential for efficient cardiac excitation-contraction coupling. In this study, we investigate how t-tubule micro-anatomy, L-type Ca(
Andrew D McCulloch +10 more
core +2 more sources
Pteridines, 1998 Cardiac myocytes are known to express the high-capacity inducible isoform of nitric oxide (NO) synthase (iNOS). Since tetrahydrobiopterin (BH4) is an essential cofactor for NO formation, we investigated whether BH4 synthesis is required for cytokine ...
Hattori Yoshiyuki +3 more
doaj +1 more source
Uptake and metabolism of the novel peptide angiotensin-(1-12) by neonatal cardiac myocytes. [PDF]
PLoS ONE, 2011 Angiotensin-(1-12) [Ang-(1-12)] functions as an endogenous substrate for the productions of Ang II and Ang-(1-7) by a non-renin dependent mechanism. This study evaluated whether Ang-(1-12) is incorporated by neonatal cardiac myocytes and the enzymatic ...
Sarfaraz Ahmad +4 more
doaj +1 more source
Biomedicines, 2023 Na/K-ATPase (NKA)-mediated regulation of Src kinase, which involves defined amino acid sequences of the NKA α1 polypeptide, has emerged as a novel regulatory mechanism of mitochondrial function in metazoans.
Liquan Cai +7 more
doaj +1 more source
Altered excitation-contraction coupling in human chronic atrial fibrillation [PDF]
, 2012 This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory ...
Grandi, E., Pandit, S.V., Workman, A.J.
core +1 more source
Gene Transfer into Cardiac Myocytes [PDF]
, 2015 Traditional methods for DNA transfection are often inefficient and toxic for terminally differentiated cells, such as cardiac myocytes. Vector-based gene transfer is an efficient approach for introducing exogenous cDNA into these types of primary cell cultures.
Sarah E, Lang, Margaret V, Westfall
openaire +2 more sources
Beating the odds: programming proliferation in the mammalian heart
Genome Medicine, 2018 Editorial summary The heart is one of the least regenerative organs in the human body; adult cardiac myocytes divide at extremely low frequency. Therefore, meaningful induction of cardiac regeneration requires in-depth understanding of myocyte cell-cycle
Rajan Jain +2 more
doaj +1 more source
Redox signaling in cardiac myocytes
Free Radical Biology and Medicine, 2011 The heart has complex mechanisms that facilitate the maintenance of an oxygen supply-demand balance necessary for its contractile function in response to physiological fluctuations in workload as well as in response to chronic stresses such as hypoxia, ischemia, and overload.
Xavier Da Costa Dos Santos, Celio Santos +4 more
openaire +3 more sources