Results 141 to 150 of about 285,913 (271)

Structure mirroring function: What's the ‘matter’ with the funny current?

The Journal of Physiology, EarlyView.
Abstract figure legend The ‘funny’ (If) current of cardiac pacemaker cells has been first identified in the late 1970s as a major mechanism in the generation and control of cardiac pacemaking. Decades of studies have since described the properties of the funny current and of its molecular components, HCN channels, in the heart and brain, providing the ...
Andrea Saponaro, Dario DiFrancesco
wiley   +1 more source

Apocynin inhibits and its removal augments L‐type Ca2+ currents in coronary artery smooth muscle cells and ventricular myocytes

The FASEB Journal, 2010
Exogenously applied H2O2 augments L‐type Ca2+ current (ICa,L). NADPH oxidase (NOX) initiates sequential reactions to generate reactive oxygen species (ROS) including H2O2. We studied the regulatory role of NOX‐generated ROS on ICa,L by applying apocynin (APO), a NOX inhibitor, and diphenyleneiodonium (DPI), a flavoprotein inhibitor.
Takashi Murayama, Nagomi Kurebayashi, Rikuo Ochi, Rakhee S. Gupte, Sachin A. Gupte   +4 more
openaire   +2 more sources

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti, Rolf Krause, Luca F. Pavarino   +2 more
wiley   +1 more source

Basal protein kinase Cδ activity is required for membrane localization and activity of TRPM4 channels in cerebral artery smooth muscle cells

Channels, 2011
The melastatin (M) transient receptor potential channel (TRP) channel TRPM4 is a critical regulator of vascular smooth muscle cell membrane potential and contractility. We recently reported that PKCδ activity influences smooth muscle cell excitability by
Zarine I Garcia, Allison Bruhl, Albert L. Gonzales, S. Earley   +3 more
semanticscholar   +1 more source

K-ATP channel gene expression is induced by urocortin and mediates its cardioprotective effect [PDF]

, 2002
Background-Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion.Methods and Results-We have ...
Chanalaris, A, Comini, L, Ferrari, R, Hubank, M, Knight, RA, Latchman, DS, Lawrence, KM, Pasini, E, Scarabelli, T, Stephanou, A, Tinker, A, Townsend, PA   +11 more
core  

The skeletal muscle response to high‐intensity training assessed by single‐nucleus RNA‐sequencing is blunted in individuals with type 2 diabetes

The Journal of Physiology, EarlyView.
Abstract figure legend The figure illustrates the impact of high‐intensity interval training (HIIT) on skeletal muscle metabolism and insulin sensitivity in individuals with type 2 diabetes and healthy controls. HIIT consists of short bursts of intense exercise followed by rest periods.
Maria Hansen, Julius E. R. Grothen, Anders Karlsen, Jaime M. Martinez, Nikos Sidiropoulos, Jørn W. Helge, Thomas Å. Pedersen, Flemming Dela   +7 more
wiley   +1 more source

The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy

EMBO Molecular Medicine, 2014
Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including preterm birth, dysfunctional labour and post‐partum haemorrhage.
Conor McCloskey, Cara Rada, Elizabeth Bailey, Samantha McCavera, Hugo A van den Berg, Jolene Atia, David A Rand, Anatoly Shmygol, Yi‐Wah Chan, Siobhan Quenby, Jan J Brosens, Manu Vatish, Jie Zhang, Jerod S Denton, Michael J Taggart, Catherine Kettleborough, David Tickle, Jeff Jerman, Paul Wright, Timothy Dale, Srinivasan Kanumilli, Derek J Trezise, Steve Thornton, Pamela Brown, Roberto Catalano, Nan Lin, Sarah K England, Andrew M Blanks   +27 more
doaj   +1 more source

BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and Response to Injury

Frontiers in Physiology, 2019
The actions of BDNF (Brain-derived Neurotrophic Factor) in regulating neuronal development and modulating synaptic activity have been extensively studied and well established.
Pouneh Kermani, Barbara Hempstead, Barbara Hempstead   +2 more
doaj   +1 more source

CASHeart: A database of single cells chromatin accessibility for the human heart

Quantitative Biology, Volume 13, Issue 2, June 2025.
Abstract Human heart single‐cell chromatin accessibility data reveal the diversity and complexity of heart cells at the epigenomic level, providing a detailed perspective for understanding the molecular mechanisms of heart development, function maintenance, disease occurrence, and therapeutic response.
Qun Jiang, Xiaoyang Chen, Zijing Gao, Jinmeng Jia, Shengquan Chen, Rui Jiang   +5 more
wiley   +1 more source

Dual ETA‐ETB receptor antagonism improves metabolic syndrome‐induced heart failure with preserved ejection fraction

Fundamental &Clinical Pharmacology, Volume 39, Issue 3, June 2025.
Abstract Background Metabolic syndrome (MetS) is a multifaceted disease associated with heart failure (HF), which affects the vascular system. The endothelin (ET) system is a key player in MetS and HF; therefore, targets for ET receptors are of therapeutic interest.
Francesca Lockwood, Marianne Lachaux, Najah Harouki, Matthieu Soulié, Lionel Nicol, Sylvanie Renet, Anaïs Dumesnil, Magali Vercauteren, Jeremy Bellien, Marc Iglarz, Vincent Richard, Paul Mulder   +11 more
wiley   +1 more source