Results 141 to 150 of about 287,296 (284)

Expression and distribution of ectonucleotidases in mouse urinary bladder.

PLoS ONE, 2011
BackgroundNormal urinary bladder function requires bidirectional molecular communication between urothelium, detrusor smooth muscle and sensory neurons and one of the key mediators involved in this intercellular signaling is ATP.
Weiqun Yu, Simon C Robson, Warren G Hill
doaj   +1 more source

K-ATP channel gene expression is induced by urocortin and mediates its cardioprotective effect [PDF]

, 2002
Background-Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion.Methods and Results-We have ...
Chanalaris, A, Comini, L, Ferrari, R, Hubank, M, Knight, RA, Latchman, DS, Lawrence, KM, Pasini, E, Scarabelli, T, Stephanou, A, Tinker, A, Townsend, PA   +11 more
core  

Characterization of the molecular and electrophysiological properties of the T-type calcium channel in human myometrium [PDF]

Rises in intracellular calcium are essential for contraction of human myometrial smooth muscle (HMSM) and hence parturition. The T-type calcium channel may play a role in this process.
Anwer, Astle, Challis, Cribbs, Eller, Fry, Garfield, Gomora, Jones, Khan, Khan, Kim, Klockner, Knock, Knock, Lee, Lee, Monteil, Moosmang, Nebe, Ohkubo, Ohkubo, Parkington, Parkington, Perez, Perez-Reyes, Perez-Reyes, Perez-Reyes, Viana, Woodcock, Young, Young, Zamponi   +32 more
core   +2 more sources

Basal protein kinase Cδ activity is required for membrane localization and activity of TRPM4 channels in cerebral artery smooth muscle cells

Channels, 2011
The melastatin (M) transient receptor potential channel (TRP) channel TRPM4 is a critical regulator of vascular smooth muscle cell membrane potential and contractility. We recently reported that PKCδ activity influences smooth muscle cell excitability by
Zarine I Garcia, Allison Bruhl, Albert L. Gonzales, S. Earley   +3 more
semanticscholar   +1 more source

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source

Apocynin inhibits and its removal augments L‐type Ca2+ currents in coronary artery smooth muscle cells and ventricular myocytes

The FASEB Journal, 2010
Exogenously applied H2O2 augments L‐type Ca2+ current (ICa,L). NADPH oxidase (NOX) initiates sequential reactions to generate reactive oxygen species (ROS) including H2O2. We studied the regulatory role of NOX‐generated ROS on ICa,L by applying apocynin (APO), a NOX inhibitor, and diphenyleneiodonium (DPI), a flavoprotein inhibitor.
Takashi Murayama, Nagomi Kurebayashi, Rikuo Ochi, Rakhee S. Gupte, Sachin A. Gupte   +4 more
openaire   +2 more sources

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy

EMBO Molecular Medicine, 2014
Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including preterm birth, dysfunctional labour and post‐partum haemorrhage.
Conor McCloskey, Cara Rada, Elizabeth Bailey, Samantha McCavera, Hugo A van den Berg, Jolene Atia, David A Rand, Anatoly Shmygol, Yi‐Wah Chan, Siobhan Quenby, Jan J Brosens, Manu Vatish, Jie Zhang, Jerod S Denton, Michael J Taggart, Catherine Kettleborough, David Tickle, Jeff Jerman, Paul Wright, Timothy Dale, Srinivasan Kanumilli, Derek J Trezise, Steve Thornton, Pamela Brown, Roberto Catalano, Nan Lin, Sarah K England, Andrew M Blanks   +27 more
doaj   +1 more source

An update on pacemaking in the myometrium

The Journal of Physiology, EarlyView.
Abstract figure legend The spread of multiple electrical signals (panel A, blue‐to‐red indicates increasing electrical excitability) that are spatiotemporally distinct, yet in‐phase with the excitatory episode, determines action potential shape and form (panel B, as recorded by single cell microelectrodes) and ensures contractile amplitude and duration
Susan Wray, Michael J. Taggart
wiley   +1 more source

Cellular and molecular cross‐talk in atrial fibrillation: The role of non‐cardiomyocytes in creating an arrhythmogenic substrate

The Journal of Physiology, EarlyView.
Abstract figure legend Illustration of cellular and molecular cross‐talk in atrial fibrillation. Left: a schematic of cardiac tissue showing cardiomyocytes, fibroblasts, adipocytes, inflammatory cells and the coagulation system. Right: direct and indirect cross‐talk between different cell types, with the impact of direct cross‐talk on action potential (
Zhenyu Dong, Ruben Coronel, Joris R. de Groot   +2 more
wiley   +1 more source