Results 151 to 160 of about 36,191 (258)

Multi‐Omics Integration Reveals Incomplete Reactivation of Developmental Cell‐Cycle Programs in Adult Human Infarcted Hearts

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Cross‐context integration of single‐nucleus, spatial, bulk transcriptomic, and chromatin accessibility data from human fetal and adult infarcted hearts reveals that infarct‐zone cardiomyocytes re‐enter the cell cycle but show insufficient reactivation of late mitotic and cytokinesis execution programs, suggesting that incomplete cytokinesis ...
Jieran Lyu, Yuki Kuramoto, Jun Li, Jong‐Kook Lee, Kyoko Hidaka, Yasushi Sakata   +5 more
wiley   +1 more source

A Randomized, Double‐Blind, Placebo‐Controlled Phase 1 Study of Adiponectin Agonist (PEG)‐BHD1028 in People With Insulin Resistance

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Low adiponectin levels may contribute to insulin resistance. This first‐in‐human study evaluated adiponectin receptor agonist (PEG)‐BHD1028 in subjects with insulin resistance. Adults with BMI ≥ 27 kg/m2, HOMA‐IR ≥ 1.8, and HbA1c < 6.5% received subcutaneous injections of (PEG)‐BHD1028 or placebo in single‐ascending dose (SAD) cohorts (4, 8 ...
Pablo Lapuerta, Brian B. Kim
wiley   +1 more source

The vascular renin-angiotensin-aldosterone system

, 2001
PhDThe renin-angiotensin-aldosterone system (RAAS) is one of the major regulators of blood pressure. The actions and generation of RAAS components at the tissue level are less well appreciated.
Xiao, Fang
core  

Breaking the Heat Tolerance Response: The Crucial Role of MFAP4 in Combating Heat‐Induced Cardiac Injury

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
MFAP4 deficiency exacerbates heatstroke outcomes, accelerating hyperthermia, delaying recovery, reducing survival, and worsening cardiac injury. Conversely, MFAP4 overexpression enhances cellular thermoresistance. MFAP4 orchestrates transcriptional reprogramming in response to HS.
LiJun Fan, MingXiao Song, QingHan Zhang, ZiYi Guo, Jing Wang, XueWei Chen, ChenYi Hu, JunYu Lu, ZhuGe Xi   +8 more
wiley   +1 more source

The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease. [PDF]

Physiol Rev
Johnson MT, Trebak M.
europepmc   +1 more source

Morphological Investigation of Uncharacterised Cardiovascular Structures in Shallow-Diving, Semi-Aquatic Freshwater Turtles (Chelidae: <i>Emydura macquarii</i>). [PDF]

Vet Sci
Gurkin RJ, Spronhle-Barrera C, Noble L, Maisel N, Gordon J, Lam C, Schaffer-White A, Origgi F, Gonzalez-Astudillo V.   +8 more
europepmc   +1 more source

The role of IP₃R and TRPC3 channels in vasoconstriction and hypertension. [PDF]

Pflugers Arch
Moraes RDA, Alves QL, da Silva LB, de Jesus RLC, Silva DF.   +4 more
europepmc   +1 more source

Type-1 Ryanodine Receptor Plays an Important Role in Cardiac Hypertrophy and Heart Failure by Increasing Type-2 Ryanodine Receptor-Mediated Calcium Release. [PDF]

Int J Mol Sci
Wang YX, Santos EW, Mistretta S, Yuan Y, Singer HA, Sheu SS, Zheng YM.   +6 more
europepmc   +1 more source

Marine Biotoxins as Potential Nematocide: Impact of Cassiopea andromeda Venom Against Acute and Chronic Trichinellosis in Murine model. [PDF]

Acta Parasitol
Elmahy RA, Salama AM, Radwan NA, Moustafa AY, Harras SF, Elwan MM.   +5 more
europepmc   +1 more source

Spatio-temporal targeting of cardiac cells with lipid nanoparticles after myocardial infarction. [PDF]

J Mol Cell Cardiol Plus
Harper RL, Farrugia GE, Krstevski C, Alexander N, Raffaut SR, Harrison T, Thomas A, Kiriazis H, Dogra A, Vidallon MLP, Wang X, Chang H, Donner DG, Lelliott PM, Pinto AR.   +14 more
europepmc   +1 more source