Results 141 to 150 of about 36,191 (258)

FKBP12.6 activates RyR1 : investigating the amino acid residues critical for channel modulation

, 2014
Funding: British Heart FoundationWe have previously shown that FKBP12 associates with RyR2 in cardiac muscle and that it modulates RyR2 function differently to FKBP12.6.
Richard B. Sessions, Elisa Venturi, O'Brien, Fiona, Rebecca Sitsapesan, Fiona O’Brien, Bellamy, Stuart, Pitt, Samantha J, Stuart Bellamy, Sitsapesan, Rebecca, Sessions, Richard B., Elena Galfré, Pitt, Samantha J., Galfre, Elena, O’Brien, Fiona, Samantha J. Pitt, Sessions, Richard B, Venturi, Elisa   +16 more
core   +1 more source

Advances in the Study of Endometrial Receptivity and Glucose Metabolism Mechanisms in Insulin Resistance

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
This article systematically reviews how insulin resistance (IR) disrupts endometrial receptivity by interfering with glucose metabolism mechanisms, ultimately leading to infertility in patients with Polycystic Ovary Syndrome (PCOS). ABSTRACT Introduction Insulin resistance (IR) is one of the important pathologic bases of polycystic ovary syndrome (PCOS)
Si‐yan Huang, Shao‐rong Chen, Wei‐hong Chen, Ling‐tao Zheng, Jing Xu, Yan‐Chuan Shi, Shu Lin, Qi‐rong Shi   +7 more
wiley   +1 more source

Immunocytochemical localization of 67 KD Ca2+ binding protein (p67) in ventricular, skeletal, and smooth muscle cells.

, 1992
By using immunocytochemical techniques, we examined the localization of a 67 kDa Ca2+ binding protein (p67) and calpactin I heavy chain (p36) in ventricular myocytes, skeletal myocytes, and intestinal smooth muscle cells.
H Iida, T Hatae, Y Shibata
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Arterial smooth muscle cell PKD2 (TRPP1) channels control systemic blood pressure

, 2018
Systemic blood pressure is determined, in part, by arterial smooth muscle cells (myocytes). Several Transient Receptor Potential (TRP) channels are proposed to be expressed in arterial myocytes, but it is unclear if these proteins control physiological ...
Padmapriya Muralidharan, Charles E. Mackay, Raquibul Hasan, Jonathan H. Jaggar, Simon Bulley, Carlos Fernandez-Pena, Sarah K. Burris, M. Dennis Leo, Kirk W. Evanson, Qian Wang, Korah P. Kuruvilla   +10 more
core   +1 more source

Structure–Activity Relationship Study on Ligands Activating the Voltage‐Gated Potassium Channel KV7.1

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Activation of the voltage gated K+ channel KV7.1 leads to hyperpolarization shift of cell membranes. In a thorough SAR study eight positions of the lead compound (R)‐L3 were modified. (R)‐configuration, the indolylmethyl moiety in 3‐position and the 2‐fluorophenyl moiety in 5‐position appeared to be essential for high KV7.1 activation, whereas an OH ...
Florian Roßner, Judith Schmidt, Guiscard Seebohm, Bernhard Wünsch   +3 more
wiley   +1 more source

Mechanism of the inhibition of Ca2+-activated Cl- currents by phosphorylation in pulmonary arterial smooth muscle cells [PDF]

, 2006
Greenwood, IA, Amy R. Sanguinetti, Leblanc, N, Iain A. Greenwood, Kenyon, JL, Jeff E. Angermann, Sanguinetti, AR, James L. Kenyon, Normand Leblanc, Angermann, JE   +9 more
core   +1 more source

Oxygen Supplementation Improves Oxygen Uptake Kinetics and Exercise Performance in PAH and CTEPH Patients

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
In patients with pulmonary vascular diseases (PAH and CTEPH), supplemental oxygen (FiO2 0.3), compared to room air (FiO2 0.21) improved peak exercise capacity (peak V̇O2), peak sustainable exercise (V̇O2 at GET), and V̇O2 kinetics and the onset of exercise.
Shir Kadosh, Yael Baidats, Andrew M. Jones, Daryl Wilkerson, Ariela Velner, Ronen Reuveny, Michael J. Segel   +6 more
wiley   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source