Results 141 to 150 of about 1,322,246 (257)

Macrophage extracellular vesicles deliver Mef2d proteins to aggravate Bacteroides fragilis pathogenicity in type 2 diabetes arterial calcification

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Bacteroides fragilis is associated with type 2 diabetes (T2D) arterial calcification and can be activated by macrophage‐derived extracellular vesicles (EVs). BF takes up EVs via receptor‐mediated endocytosis, and activation is induced by EV‐derived Mef2d, thereby inhibiting ArsR family transcriptional regulator transcription.
Cong Chen, Rong He, Jirong Luo, Zhengfeng Liang, Qunwen Pan, Shuangquan Liu, Jingsong Cao   +6 more
wiley   +1 more source

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

MedComm, Volume 7, Issue 9, September 2026.
The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song, Xi Liu, Yang Xiao, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

A Platform for the Actuation of Magnetically Labeled Skeletal Muscle Cells Using Dynamic Magnetic Stimulation

Small, Volume 22, Issue 49, 1 September 2026.
A magnetic stimulation platform for the remote stimulation of cells is presented, consisting of a magnetic stimulator and magnetic microspheres. Skeletal muscle cells are labeled with magnetic microspheres, which act as local magnetic actuators on the cells upon application of the magnetic field.
Tayná C. Rodrigues, Anna‐Lena Bauknecht, Anna Gioran, Sabine Rosenfeldt, Daniel Dickes, Johann Schorzmann, Frank Döpper, Elisabetta A. Cavalcanti‐Adam, Michael Maier, Reinhard Richter, Marissa K. Caldow, Gordon S. Lynch, Daniel E. Heath, Andrea J. O'Connor, Sahar Salehi   +14 more
wiley   +1 more source

Catalytic Nitric Oxide‐Generating Selenium Nanoparticle‐Loaded Hydrogels With Anti‐Inflammatory and Pro‐Wound‐Healing Properties

Small Science, Volume 6, Issue 9, September 2026.
Polydopamine‐coated selenium nanoparticle (Se@PDA)‐loaded hydrogels enable sustained and tunable catalytic nitric oxide (NO) generation from S‐nitrosoglutathione (GSNO). The hydrogels exhibit excellent stability, recyclability, and biocompatibility, while elevating IL‐10 expression in endothelial cells and smooth muscle cells and increasing α‐SMA ...
Shu Geng, Kang Lin, Qingqing Fan, Yulong Sun, Federico Mazur, Rona Chandrawati   +5 more
wiley   +1 more source

The Therapeutic Potential of Purmorphamine Across Disease Models

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT Purmorphamine (PUR) is a trisubstituted purine compound that selectively activates Smoothened receptor, thereby initiating Sonic Hedgehog (Shh) signalling—a pathway critical for embryonic patterning, neuronal specification and tissue regeneration across multiple organ systems. Dysregulation of Shh signalling has been implicated in degenerative
Ashis Dhar, Ahnaf Dil Sharar, Saikarthik Papisetty, Mohammad Bydon, F. M. Moinuddin   +4 more
wiley   +1 more source

Mechanism of the inhibition of Ca2+-activated Cl- currents by phosphorylation in pulmonary arterial smooth muscle cells [PDF]

, 2006
Greenwood, IA, Amy R. Sanguinetti, Leblanc, N, Iain A. Greenwood, Kenyon, JL, Jeff E. Angermann, Sanguinetti, AR, James L. Kenyon, Normand Leblanc, Angermann, JE   +9 more
core   +1 more source

Cellular and molecular components of the atherosclerotic process: Primary colture and characterization of human vascular smooth muscle cells from carotid artery [PDF]

, 2009
Introduction The last years were characterized by several studies proceeding to understand SMC heterogeneity. Animal models of rat or rabbit IT after endothelial lesion are presently the most studied models for atherosclerotic plaque formation and ...
Gagliano, Teresa
core  

Adaptive Variation Amid High Gene Flow Across a Broad Latitudinal Gradient in the Reef‐Building Honeycomb Worm, Sabellaria alveolata

Molecular Ecology, Volume 35, Issue 17, September 2026.
ABSTRACT Climate change is already altering, and will continue to reshape, the persistence and spatial structure of marine populations. Understanding metapopulation connectivity and local adaptation is therefore critical for identifying both vulnerable populations and those with adaptive resilience.
Edward J. Wilson, Antony M. Knights, Louise B. Firth, Charlotte Corporeau, Amelia Curd, Stanislas F. Dubois, Fernando P. Lima, Rui Seabra, Flavia L. D. Nunes   +8 more
wiley   +1 more source

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, Volume 111, Issue 9, Page 3944-3967, 1 September 2026.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source