Results 211 to 220 of about 36,191 (258)

Three-Dimensional Culture of Human Uterine Smooth Muscle Myocytes on a Resorbable Scaffolding

Tissue Engineering, 2003
The objective of this study was to develop a three-dimensional culture system for the study of human myometrial physiology. Primary cell lines were initiated from human myometrium obtained at the time of term cesarean delivery. After several passages, cells were seeded onto a polyglactin-910 (Vicryl) mesh and maintained in culture.
Roger C, Young, Ralph, Schumann, Peisheng, Zhang   +2 more
openaire   +2 more sources

Altered Ion Channel Activity in Murine Colonic Smooth Muscle Myocytes in an Experimental Colitis Model

Biochemical and Biophysical Research Communications, 2000
We have investigated the activity of calcium and potassium channels in a murine model of experimental colitis. Colonic myocytes from dextran sulphate sodium (DSS)-treated mice were examined by whole cell patch clamp techniques. Myeloperoxidase activity was enhanced 3. 5-fold in DSS-treated mouse colon.
AKBARALI HI, POTHOULAKIS C, CASTAGLIUOLO, IGNAZIO   +2 more
openaire   +3 more sources

Vesnarinone Inhibits Adenosine Uptake in Endothelial Cells, Smooth Muscle Cells and Myocytes, and Mediates Cytoprotection

Journal of Molecular and Cellular Cardiology, 1997
Vesnarinone is a novel synthetic inotropic agent. Recently, it has been reported that vesnarinone inhibits adenosine uptake in the B-lymphocytoid cell line. Since extracellular adenosine is cardioprotective, we examined whether vesnarinone inhibits adenosine uptake in cells constituting the cardiovascular system. 1 microCi of -3H-adenosine was added to
M, Kitakaze, M, Fong, M, Yoshitake, T, Minamino, K, Node, Y, Okuyama, N, Terada, T, Kambayashi, M, Hori   +8 more
openaire   +2 more sources

Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A expressed in vascular smooth-muscle myocytes

Biochemical Journal, 2000
We have identified a new cyclic-nucleotide phosphodiesterase isoform, PDE3A, and cloned its cDNA from cultured aortic myocytes. The nucleotide sequence of its coding region is similar to that of the previously cloned myocardial isoform except for the absence of the initial 300–400nt that are present in the latter, as confirmed by reverse-transcriptase ...
Y H, Choi, D, Ekholm, J, Krall, F, Ahmad, E, Degerman, V C, Manganiello, M A, Movsesian   +6 more
openaire   +2 more sources

Myocyte Enhancer Binding Factor-2 Expression and Activity in Vascular Smooth Muscle Cells

Circulation Research, 1996
Abstract Proliferation and phenotypic modulation of smooth muscle cells (SMCs) are major components of the vessel’s response to injury in experimental models of restenosis. Some of the growth factors involved in restenosis have been identified, but to date little is known about the transcription factors that ultimately regulate
A B, Firulli, J M, Miano, W, Bi, A D, Johnson, W, Casscells, E N, Olson, J J, Schwarz   +6 more
openaire   +2 more sources

The effects of myocyte enhancer factor 2A gene on the proliferation, migration and phenotype of vascular smooth muscle cells

Cell Biochemistry and Function, 2011
The genetic basis for the phenotypic switching of vascular smooth muscle cells (VSMCs) is unclear in atherosclerosis. Recent studies showed that the 21‐base pair deletion mutation (Δ21) in myocyte enhancer factor 2A (MEF2A) gene could be an inherited marker for coronary artery disease. MEF2A mutation may affect the phenotypic switching of VSMCs.
Wang, Zhao, Shui-ping, Zhao, Dao-quan, Peng   +2 more
openaire   +2 more sources

High-efficiency somatic mutagenesis in smooth muscle cells and cardiac myocytes in SM22?-Cre transgenic mice

genesis, 2005
The cytoskeletal protein SM22alpha is expressed in visceral and vascular smooth muscle cells (SMCs), in cardiac myocytes, and in the myotomal components of the somites during murine embryonic development. In this report, we describe the generation and characterization of transgenic mice expressing Cre-recombinase under the transcriptional control of ...
John J, Lepore, Lan, Cheng, Min, Min Lu, Patricia A, Mericko, Edward E, Morrisey, Michael S, Parmacek   +5 more
openaire   +2 more sources

The role of mechanical and humoral factors in growth regulation of vascular smooth muscle and cardiac myocytes

Current Opinion in Nephrology and Hypertension, 1993
Structural changes of the heart and blood vessels participate in the long-term regulation of the cardiovascular system. In hypertension and myocardial dysfunction, the adaptive process of cardiac and vascular remodeling may contribute to the pathophysiology and complications of these diseases.
openaire   +2 more sources

Membrane Actions of Calcitonin Gene‐Related Peptide in Cardiac and Smooth Muscle Myocytesa

Annals of the New York Academy of Sciences, 1992
Calcitonin gene-related peptide is a 37-amino acid neuropeptide acting as a transmitter of nonadrenergic, noncholinergic nerves in the heart. Binding sites of high affinity have been reported in coronary arteries, in atria, and, of minor density, in ventricular myocardium.
H A, Tritthart, U, Stark, G, Stark, W, Mahnert, C O, Stender, W, Schreibmayer   +5 more
openaire   +2 more sources

A mechanism for testosterone modulation of alpha-1 adrenergic receptor expression in the DDT1 MF-2 smooth muscle myocyte

Molecular and Cellular Biochemistry, 1991
Previous reports have confirmed that steroid hormones modulate the expression of adrenergic receptors on the surface of smooth muscle myocytes. The present study was undertaken to evaluate the mechanism by which testosterone modulates alpha-1 adrenergic receptor expression in the DDT1 MF-2 transformed smooth muscle cell.
M, Phillippe, T, Saunders, S, Bangalore
openaire   +2 more sources