Results 61 to 70 of about 35,109 (214)

The ciliary neurotrophic factor induces Stat3 phosphorylation in distinctive cytotypes of organs involved in body metabolism: An immunohistochemical study

Journal of Anatomy, EarlyView.
p‐STAT3‐positive cells in metabolically relevant peripheral organs and tissues from mice administered with recombinant CNTF (0.3 mg/kg). Abstract Administration of ciliary neurotrophic factor (CNTF) reduces food intake and body weight in both humans and experimental animals, where it also ameliorates hyperglycemia, hyperinsulinemia, and dyslipidemia ...
Chiara Galli, Georgia Colleluori, Jessica Perugini, Edoardo Scopini, Ilenia Severi, Gaia Grandin, Antonio Giordano   +6 more
wiley   +1 more source

Role of Ryanodine Type 2 Receptors in Elementary Ca2+ Signaling in Arteries and Vascular Adaptive Responses

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Hypertension is the major risk factor for cardiovascular disease, the most common cause of death worldwide. Resistance arteries are capable of adapting their diameter independently in response to pressure and flow‐associated shear stress ...
Mario Kaßmann, István András Szijártó, Concha F. García‐Prieto, Gang Fan, Johanna Schleifenbaum, Yoland‐Marie Anistan, Christoph Tabeling, Yu Shi, Ferdinand le Noble, Martin Witzenrath, Yu Huang, Lajos Markó, Mark T. Nelson, Maik Gollasch   +13 more
doaj   +1 more source

Functional and autoradiographic evidence for endothelin 1 receptors on human and rat cardiac myocytes. Comparison with single smooth muscle cells. [PDF]

Circulation Research, 1990
This study aimed to determine whether receptors for endothelin were present on the cardiac myocyte as well as on vascular smooth muscle cells. Low- and high-resolution autoradiography was performed using 125I-endothelin 1 on intact rat myocardium and samples of human ventricle obtained from explanted hearts at the time of transplant.
C J, Moody, M R, Dashwood, R M, Sykes, M, Chester, S M, Jones, M H, Yacoub, S E, Harding   +6 more
openaire   +2 more sources

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source

Expression and function of calcium-activated potassium channels following in-stent restenosis in a porcine coronary artery model

Journal of Advanced Research, 2012
In-stent restenosis (ISR) occurs due to proliferation and migration of smooth muscle cells from media to intima resulting in re-narrowing of the vessel lumen.
Mais F. Absi, Gillian Edwards, Arthur H. Weston   +2 more
doaj   +1 more source

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

Tumor Necrosis Factor Alpha Inhibits L-Type Ca2+ Channels in Sensitized Guinea Pig Airway Smooth Muscle through ERK 1/2 Pathway

Mediators of Inflammation, 2016
Tumor necrosis factor alpha (TNF-α) is a potent proinflammatory cytokine that plays a significant role in the pathogenesis of asthma by inducing hyperresponsiveness and airway remodeling. TNF-α diminishes the L-type voltage dependent Ca2+ channel (L-VDCC)
Jorge Reyes-García, Edgar Flores-Soto, Héctor Solís-Chagoyán, Bettina Sommer, Verónica Díaz-Hernández, Luz María García-Hernández, Luis M. Montaño   +6 more
doaj   +1 more source

Putting the brakes on muscle growth: Myostatin as regulator of disuse atrophy

Experimental Physiology, EarlyView.
Abstract Skeletal muscle is a highly plastic tissue that rapidly adapts to changes in mechanical loading and metabolic activity. Periods of inactivity, including bed rest, limb immobilization or microgravity, induce a pronounced loss of muscle mass and function.
Derk H. C. Nieuwenhuijsen, Moritz Eggelbusch, Rob C. I. Wüst   +2 more
wiley   +1 more source

Calcium handling by vascular myocytes in hypertension

Brazilian Journal of Medical and Biological Research, 1997
Calcium ions (Ca2+) trigger the contraction of vascular myocytes and the level of free intracellular Ca2+ within the myocyte is precisely regulated by sequestration and extrusion mechanisms. Extensive evidence indicates that a defect in the regulation of
R.C.A. Tostes, D.W. Wilde, L.M. Bendhack, R.C. Webb   +3 more
doaj   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source