Results 201 to 210 of about 32,334 (225)

Ret finger protein mediates Pax7-induced ubiquitination of MyoD in skeletal muscle atrophy

Cellular Signalling, 2014
Skeletal muscle atrophy results from the net loss of muscular proteins and organelles and is caused by pathologic conditions such as nerve injury, immobilization, cancer, and other metabolic diseases. Recently, ubiquitination-mediated degradation of skeletal-muscle-specific transcription factors was shown to be involved in muscle atrophy, although the ...
HoSouk Joung, Gwang Hyeon Eom, Jeong-Hyeon Ko   +2 more
exaly   +3 more sources

Tumor necrosis factor‐alpha inhibits myogenic differentiation through MyoD protein destabilization

FASEB Journal, 2004
Tumor necrosis factor α (TNFα) has been implicated as a mediator of muscle wasting through nuclear factor kappa B (NF‐ΚB) ‐dependent inhibition of myogenic differentiation. The aim of the present study was to identify the regulatory molecule(s) of myogenesis targeted by TNFα/NF‐κΒ signaling. TNFα interfered with cell cycle exit and
Annemie M W J Schols, Marco C J M Kelders, Yvonne M W Janssen-Heininger   +2 more
exaly   +3 more sources

Interplay between two myogenesis-related proteins: TBP-interacting protein 120B and MyoD

Gene, 2012
Gene expression in myogenesis is governed by multiple myogenic factors including MyoD. Previously, we demonstrated that TBP-interacting protein 120B (TIP120B) promotes in vitro myogenesis through its anti-ubiquitination ability. In this study, we investigated interplay between MyoD and TIP120B.
Hidefumi, Suzuki, Ai, Suzuki, Yui, Maekawa, Seiji, Shiraishi, Taka-aki, Tamura   +4 more
openaire   +2 more sources

The adaptive response of MyoD family proteins in overloaded, regenerating and denervated rat muscles

Biochimica et Biophysica Acta (BBA) - General Subjects, 1999
Using Western blot analysis, we investigated whether the amount of myogenic regulatory factors differs in slow-type and fast-type muscles. In addition, we examined the adaptive response of myogenic regulatory factor protein in the overloaded rat muscles by the ablation of synergists, in the regenerating muscles following bupivacaine injection and in ...
Sakuma K, Watanabe K, Sano M, Sakamoto K, Uramoto I, Totsuka T   +5 more
openaire   +2 more sources

Efficient myogenic differentiation of human adipose-derived stem cells by the transduction of engineered MyoD protein

Biochemical and Biophysical Research Communications, 2013
Human adipose-derived stem cells (hASCs) have great potential as cell sources for the treatment of muscle disorders. To provide a safe method for the myogenic differentiation of hASCs, we engineered the MyoD protein, a key transcription factor for myogenesis.
Ohsuk Kwon, Ki-Sun Kwon, Doo-Byoung Oh   +2 more
exaly   +3 more sources

Rapamycin-induced autophagy decreases Myf5 and MyoD proteins in C2C12 myoblast cells

Toxicology in Vitro, 2019
Rapamycin is an immunosuppressant that inhibits the mammalian or mechanistic target of rapamycin (mTOR) protein kinase and extends lifespan in organisms including mice. Myf5 and MyoD act as muscle-specific transcriptional factors for skeletal muscle differentiation. In this study, we determined whether rapamycin-induced autophagy causes the decrease of
Yeong-Min Yoo, Eui-Man Jung, Eui-Bae Jeung   +2 more
openaire   +2 more sources

Functional antagonism between c-Jun and MyoD proteins: A direct physical association

Cell, 1992
The product of the proto-oncogene Jun inhibits myogenesis. Constitutive expression of Jun in myoblasts interferes with the expression and the function of MyoD protein. In transient transfection assays Jun inhibits transactivation of the MyoD promoter, the muscle creatine kinase enhancer, and a reporter gene linked to MyoD DNA-binding sites. Conversely,
E, Bengal, L, Ransone, R, Scharfmann, V J, Dwarki, S J, Tapscott, H, Weintraub, I M, Verma   +6 more
openaire   +2 more sources

Interaction of the porcine reproductive and respiratory syndrome virus nucleocapsid protein with the inhibitor of MyoD family-a domain-containing protein

bchm, 2008
Abstract Porcine reproductive and respiratory syndrome (PRRS) virus is an RNA virus that replicates in the cytoplasm, but the viral nucleocapsid (N) protein localizes specifically in the nucleus and nucleolus of virus-infected cells. Nuclear localization of N is non-essential for PRRSV replication in cultured cells but has been shown to ...
Cheng, Song, Ray, Lu, Dorothee, Bienzle, Hsiao-Ching, Liu, Dongwan, Yoo   +4 more
openaire   +2 more sources

Regulation of Muscle Cell Growth and Differentiation by the Myod Family of Helix-Loop-Helix Proteins

1992
The skeletal muscle cell system provides a powerful model for exploring the mechanistic basis for the antagonism between cell growth and differentiation. The recent identification of the MyoD family of muscle-specific transcription factors now offers opportunities to dissect at the molecular level of the mechanisms through which defined cell type ...
L, Li, E N, Olson
openaire   +2 more sources

Affinity of synthetic peptide fragments of MyoD for Id1 protein and their biological effects in several cancer cells

Journal of Peptide Science, 2010
AbstractMyoD is a DNA‐binding protein capable of specific interactions that involve the helix–loop–helix (HLH) domain. The HLH motif of MyoD can form oligomers with the HLH motif of Id1 (the inhibitor of DNA‐binding proteins) that folds into a highly stable helical conformation stabilized by the self‐association.
Chiu-Heng, Chen, Sheng-Chu, Kuo, Li-Jiau, Huang, Mei-Hua, Hsu, Feng-Di T, Lung   +4 more
openaire   +2 more sources