Results 1 to 10 of about 11,246 (181)

A Pax7::Foxo1 conditional mouse strain [PDF]

Skeletal Muscle
Background The PAX7::FOXO1 subtype of alveolar rhabdomyosarcoma (aRMS) is both understudied and an unmet clinical need. The biology of PAX7::FOXO1 aRMS is significantly different than PAX3::FOXO1 aRMS, presenting an opportunity to gain biological ...
G. Roger Askew, Jonathan Gauntlett, Katherine Brechun, Harald Kranz, Nicholas Salters, Jess D. Tate, Ellen Wang, Cassie Badger, Shireen Elhabian, Jared Schnider, Gillian St. John, Samuel V. Rasmussen, Narendra Bharathy, Charles Keller   +13 more
doaj   +3 more sources

Pax7 lineage contributions to the mammalian neural crest.

PLoS ONE, 2012
BackgroundNeural crest cells are vertebrate-specific multipotent cells that contribute to a variety of tissues including the peripheral nervous system, melanocytes, and craniofacial bones and cartilage.
Barbara Murdoch, Casey DelConte, Martín I García-Castro   +2 more
doaj   +6 more sources

Spontaneous Physical Activity Downregulates Pax7 in Cancer Cachexia [PDF]

Stem Cells International, 2016
Emerging evidence suggests that the muscle microenvironment plays a prominent role in cancer cachexia. We recently showed that NF-kB-induced Pax7 overexpression impairs the myogenic potential of muscle precursors in cachectic mice, suggesting that ...
Dario Coletti, Paola Aulino, Eva Pigna, Fabio Barteri, Viviana Moresi, Daniela Annibali, Sergio Adamo, Emanuele Berardi   +7 more
doaj   +6 more sources

SUMOylation of Pax7 is essential for neural crest and muscle development [PDF]

Cellular and Molecular Life Sciences, 2012
Regulatory transcription factors of the Pax family play fundamental roles in the function of multipotent cells during vertebrate development, post-natal regeneration, and cancer. Pax7 and its homologue Pax3 are important players in neural crest and muscle development. Both genes are coexpressed in various tissues and are thought to provide similar, but
Martin I García-Castro, Jonathan Marquez   +1 more
exaly   +3 more sources

Pax7 Is Required for the Specification of Myogenic Satellite Cells [PDF]

Cell, 2000
The paired box transcription factor Pax7 was isolated by representational difference analysis as a gene specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization revealed that Pax7 was also expressed in satellite cells residing in adult muscle.
Patrick Seale, Michael A Rudnicki, P Gruss   +2 more
exaly   +4 more sources

The regenerative potential of Pax3/Pax7 on skeletal muscle injury

Journal of Genetic Engineering and Biotechnology, 2022
Background Skeletal muscle mishaps are the most well-known incidents in society, especially among athletes and the military population. From the various urgency, this accident needs to be cured more quickly.
Muhamad Azhar, Bantari Wisynu Kusuma Wardhani, Editha Renesteen   +2 more
doaj   +3 more sources

Biallelic PAX7 variants cause a novel Satellite Cell-opathy with progressive muscle involvement resembling facioscapulohumeral muscular dystrophy [PDF]

Cell Death and Disease
Inherited myopathies are genetic disorders characterised by declining motor function due to progressive muscle weakening and wasting. Recently, pathogenic variants in PAX7, the master transcriptional regulator of muscle stem cells, have been associated ...
Massimo Ganassi, Claudia Strafella, Marco Savarese, Philipp Heher, Elise N. Engquist, Liam McGuire, Mridul Johari, Gian F. De Nicola, Anne Bigot, Vincent Mouly, Sara Bortolani, Eleonora Torchia, Mauro Monforte, Domenica Megalizzi, Andrea Sabino, Enzo Ricci, Emiliano Giardina, Peter S. Zammit, Giorgio Tasca   +18 more
doaj   +2 more sources

Pax7 is back [PDF]

Skeletal Muscle, 2014
Two recent studies have reinvigorated the conversation regarding the role of Pax7 in adult satellite. Studies by Gunther et al (Cell Stem Cell 13:590-601, 2013) and Von Maltzhen et al (Proc Natl Acad Sci U S A 110:16474-16479) show that Pax7 is critical for adult satellite cell function and their contribution to muscle repair. Previously, Lepper et al (
Brack, Andrew, Brack, AS
openaire   +6 more sources

The fibronectin concentration that optimally maintains porcine satellite cells [PDF]

Animal Bioscience, 2023
Objective ‘Cultured meat’ has been suggested as means of solving the problems associated with overpopulation and gas emissions. Satellite cells are a major component in the production of cultured meat; however, these cells cannot be maintained in vitro ...
Jae Ho Han, Si Won Jang, Ye Rim Kim, Hoon Jang, Kwan Seob Shim, Hyun Woo Choi   +5 more
doaj   +1 more source

c-Abl Kinase Is Required for Satellite Cell Function Through Pax7 Regulation

Frontiers in Cell and Developmental Biology, 2021
Satellite cells (SCs) are tissue-specific stem cells responsible for adult skeletal muscle regeneration and maintenance. SCs function is critically dependent on two families of transcription factors: the paired box (Pax) involved in specification and ...
Fabián Montecino, Natalia González, Natasha Blanco, Manuel J. Ramírez, Adrián González-Martín, Alejandra R. Alvarez, Hugo Olguín   +6 more
doaj   +1 more source