Pax7 is necessary and sufficient for the myogenic specification of CD45+:Sca1+ stem cells from injured muscle. [PDF]
PLoS Biology, 2004 CD45(+):Sca1(+) adult stem cells isolated from uninjured muscle do not display any myogenic potential, whereas those isolated from regenerating muscle give rise to myoblasts expressing the paired-box transcription factor Pax7 and the bHLH factors Myf5 ...
Patrick Seale +3 more
doaj +1 more source
Targeting PKCθ promotes satellite cell self-renewal [PDF]
, 2020 Skeletal muscle regeneration following injury depends on the ability of satellite cells (SCs) to proliferate, self-renew, and eventually differentiate. The factors that regulate the process of self-renewal are poorly understood. In this study we examined
Benedetti, Anna +4 more
core +1 more source
Cadherin-7 enhances Sonic Hedgehog signalling by preventing Gli3 repressor formation during neural tube patterning [PDF]
, 2017 Sonic Hedgehog (Shh) is a ventrally enriched morphogen controlling dorsoventral patterning of the neural tube. In the dorsal spinal cord, Gli3 protein bound to suppressor-of-fused (Sufu) is converted into Gli3 repressor (Gli3R), which inhibits Shh-target
Kawano, Rie +2 more
core +1 more source
Czech Journal of Animal Science, 2021 Ubiquitin-specific protease 8 (USP8), a member of the ubiquitin-specific protease (USP) family, was originally identified as playing a role in the regulation of growth and cell cycle. However, its functional role in myogenesis is unknown.
Shaoyu Wang +6 more
doaj +1 more source
New insights into the epigenetic control of satellite cells [PDF]
, 2015 Epigenetics finely tunes gene expression at a functional level without modifying the DNA sequence, thereby contributing to the complexity of genomic regulation.
Adamo, Sergio +2 more
core +1 more source
A Poglut1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss [PDF]
, 2016 Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and regulated by Notch signaling. In a family with autosomal recessive limbgirdle muscular dystrophy, we identified a missense mutation in ...
Cabrera Serrano, Macarena +5 more
core +1 more source
Biosensors, 2023 The principles of myogenesis play crucial roles in the production of cultured meat, and identifying protein stimulators associated with myogenesis holds great potential to enhance the efficiency of this process.
In-Sun Yu +6 more
doaj +1 more source
Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay. [PDF]
, 2015 Skeletal muscle satellite cells in their niche are quiescent and upon muscle injury, exit quiescence, proliferate to repair muscle tissue, and self-renew to replenish the satellite cell population.
Blackshear, Perry J +7 more
core +2 more sources
Pax3 Hypomorphs Reveal Hidden Pax7 Functional Genetic Compensation in Utero
Journal of Developmental Biology, 2022 Pax3 and Pax7 transcription factors are paralogs within the Pax gene family that that are expressed in early embryos in partially overlapping expression domains and have distinct functions.
Hong-Ming Zhou, Simon J. Conway
doaj +1 more source
The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration. [PDF]
, 2019 Metabolic reprogramming is an active regulator of stem cell fate choices, and successful stem cell differentiation in different compartments requires the induction of oxidative phosphorylation.
Cunningham, Thomas J +9 more
core +3 more sources