Results 11 to 20 of about 19,447 (222)

Pax7 lineage contributions to the mammalian neural crest.

PLoS ONE, 2012
BackgroundNeural crest cells are vertebrate-specific multipotent cells that contribute to a variety of tissues including the peripheral nervous system, melanocytes, and craniofacial bones and cartilage.
Barbara Murdoch, Casey DelConte, Martín I García-Castro   +2 more
doaj   +6 more sources

A Pax7::Foxo1 conditional mouse strain

Skeletal Muscle
Background The PAX7::FOXO1 subtype of alveolar rhabdomyosarcoma (aRMS) is both understudied and an unmet clinical need. The biology of PAX7::FOXO1 aRMS is significantly different than PAX3::FOXO1 aRMS, presenting an opportunity to gain biological ...
G. Roger Askew, Jonathan Gauntlett, Katherine Brechun, Harald Kranz, Nicholas Salters, Jess D. Tate, Ellen Wang, Cassie Badger, Shireen Elhabian, Jared Schnider, Gillian St. John, Samuel V. Rasmussen, Narendra Bharathy, Charles Keller   +13 more
doaj   +2 more sources

The regenerative potential of Pax3/Pax7 on skeletal muscle injury

Journal of Genetic Engineering and Biotechnology, 2022
Background Skeletal muscle mishaps are the most well-known incidents in society, especially among athletes and the military population. From the various urgency, this accident needs to be cured more quickly.
Muhamad Azhar, Bantari Wisynu Kusuma Wardhani, Editha Renesteen   +2 more
doaj   +3 more sources

Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo-Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men. [PDF]

Adv Sci (Weinh)
In a randomized clinical trial, we test the potential of combined nicotinamide (NAM) and pyridoxine (PN) to improve muscle recovery through muscle stem cell (MuSC) activity. Daily oral NAM and PN supplementation after high intensity muscle contractions enhances MuSC activation and differentiation, and accelerates muscle regeneration, providing new ...
Højfeldt G, Michaud J, Damgaard A, Karlog K, Migliavacca E, Karaz S, Pazirandeh-Micol E, Johansen OE, Karagounis LG, Helge BW, Hagemann W, Kjaer M, Feige JN, Stuelsatz P, Mackey AL.   +14 more
europepmc   +2 more sources

Pax7 is back [PDF]

Skeletal Muscle, 2014
Two recent studies have reinvigorated the conversation regarding the role of Pax7 in adult satellite. Studies by Gunther et al (Cell Stem Cell 13:590-601, 2013) and Von Maltzhen et al (Proc Natl Acad Sci U S A 110:16474-16479) show that Pax7 is critical for adult satellite cell function and their contribution to muscle repair. Previously, Lepper et al (
Brack, Andrew, Brack, AS
openaire   +5 more sources

PAX7 is required for patterning the esophageal musculature [PDF]

Skeletal Muscle, 2015
Background The mammalian esophageal musculature is unique in that it makes a transition from smooth to skeletal muscle, with most of this process occurring after birth. In order to better understand the mechanisms that control esophageal musculature development, we investigated the roles in this process of the paired box transcription factor, PAX7, a ...
Chihara, Daisuke, Romer, Anthony I, Bentzinger, C. F, Rudnicki, Michael A, Krauss, Robert S   +4 more
openaire   +6 more sources

Effect of induced diabetes on morphometric indexes of the cerebellar cortex and gene expression in C57BL mice [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Diabetes is a metabolic disorder that affects the development of the central nervous system and plays an important role in learning and memory.
Somayeh Sharifi, Masoud Golalipour, Soraya Ghafari, Razieh Safari, Mohammad Jafar Golalipour   +4 more
doaj   +1 more source

Granulin Knock Out Zebrafish Lack Frontotemporal Lobar Degeneration and Neuronal Ceroid Lipofuscinosis Pathology [PDF]

, 2015
Loss of function mutations in granulin (GRN) are linked to two distinct neurological disorders, frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL).
Haass, C, Kremmer, E, Russell, C, Schmid, B, Solchenberger, B   +4 more
core   +16 more sources

Pax7 as molecular switch regulating early and advanced stages of myogenic mouse ESC differentiation in teratomas

Stem Cell Research & Therapy, 2020
Background Pluripotent stem cells present the ability to self-renew and undergo differentiation into any cell type building an organism. Importantly, a lot of evidence on embryonic stem cell (ESC) differentiation comes from in vitro studies.
Anita Florkowska, Igor Meszka, Magdalena Zawada, Diana Legutko, Tomasz J. Proszynski, Katarzyna Janczyk-Ilach, Wladyslawa Streminska, Maria A. Ciemerych, Iwona Grabowska   +8 more
doaj   +1 more source

In Vivo Gene Editing of Muscle Stem Cells with Adeno-Associated Viral Vectors in a Mouse Model of Duchenne Muscular Dystrophy

Molecular Therapy: Methods & Clinical Development, 2020
Delivery of therapeutic transgenes with adeno-associated viral (AAV) vectors for treatment of myopathies has yielded encouraging results in animal models and early clinical studies.
Jennifer B. Kwon, Adarsh R. Ettyreddy, Ashish Vankara, Joel D. Bohning, Garth Devlin, Stephen D. Hauschka, Aravind Asokan, Charles A. Gersbach   +7 more
doaj   +1 more source