Results 31 to 40 of about 11,246 (181)

Multipotency and physiological role of skeletal muscle interstitium-derived stem cells

Journal of Physical Fitness and Sports Medicine, 2012
Multipotent stem cells, other than satellite cells, that can give rise to primary myoblasts postnatally, are present in the interstitial spaces of skeletal muscle.
Tetsuro Tamaki
doaj   +1 more source

The emergence of Pax7-expressing muscle stem cells during vertebrate head muscle development

Frontiers in Aging Neuroscience, 2015
Pax7 expressing muscle stem cells accompany all skeletal muscles in the body and in healthy individuals, efficiently repair muscle after injury. Currently, the in vitro manipulation and culture of these cells is still in its infancy, yet muscle stem ...
Julia eMeireles Nogueira, Julia eMeireles Nogueira, Katarzyna eHawrot, Colin eSharpe, Anna eNoble, William M. Wood, Erika C. Jorge, David J. Goldhamer, Gabrielle eKardon, Susanne eDietrich   +9 more
doaj   +1 more source

Shape analysis of the basioccipital bone in Pax7-deficient mice [PDF]

Scientific Reports, 2017
AbstractWe compared the cranial base of newbornPax7-deficient and wildtype mice using a computational shape modeling technology called particle-based modeling (PBM). We found systematic differences in the morphology of the basiooccipital bone, including a broadening of the basioccipital bone and an antero-inferior inflection of its posterior edge in ...
Joshua Cates, Lisa Nevell, Suresh I. Prajapati, Laura D. Nelon, Jerry Y. Chang, Matthew E. Randolph, Bernard Wood, Charles Keller, Ross T. Whitaker   +8 more
openaire   +2 more sources

Simultaneous RNA Fluorescent In Situ Hybridization and Immunofluorescent Staining of Mouse Muscle Stem Cells on Fresh Frozen Skeletal Muscle Sections

Bio-Protocol
Adult muscle stem cells (MuSCs) are the key cellular source for regenerating skeletal muscle in vertebrates. MuSCs are typically identified in skeletal muscle by the expression of the paired box protein 7 (PAX7) protein. Here, we developed a combined RNA
Vedant Lakkundi, Maria Perez, Kartik Soni, Albert Almada   +3 more
doaj   +1 more source

Satellite cell activity is differentially affected by contraction mode in human muscle following a work-matched bout of exercise

Frontiers in Physiology, 2014
Optimal repair and adaptation of skeletal muscle is facilitated by resident stem cells (satellite cells). To understand how different exercise modes influence satellite cell dynamics, we measured satellite cell activity in conjunction with markers of ...
Robert D Hyldahl, Ty eOlson, Tyson eWelling, Logan eGroscost, Allen Clive Parcell   +4 more
doaj   +1 more source

Pax7 remodels the chromatin landscape in skeletal muscle stem cells. [PDF]

PLoS ONE, 2017
Pluripotent stem cells (PSC) hold great promise for the treatment of human skeletal muscle diseases. However, it remains challenging to convert PSC to skeletal muscle cells, and the mechanisms by which the master regulatory transcription factor, Pax7 ...
Karin C Lilja, Nan Zhang, Alessandro Magli, Volkan Gunduz, Christopher J Bowman, Robert W Arpke, Radbod Darabi, Michael Kyba, Rita Perlingeiro, Brian D Dynlacht   +9 more
doaj   +1 more source

Generation of skeletal muscle cells from pluripotent stem cells: advances and challenges

Frontiers in Cell and Developmental Biology, 2015
Human pluripotent stem cells (hPSCs) possess unlimited proliferative potential while maintaining the ability to differentiate into any cell type including skeletal muscle cells (SMCs). hPSCs are amenable to genetic editing and can be derived from patient
Ramzey eAbujarour, Bahram eValamehr
doaj   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

Therapeutic isolation and expansion of human skeletal muscle-derived stem cells for the use of muscle-nerve-blood vessel reconstitution

Frontiers in Physiology, 2015
Skeletal muscle makes up 40-50% of body mass, and is thus considered to be a good adult stem cell source for autologous therapy. Although, several stem/progenitor cells have been fractionated from mouse skeletal muscle showing a high potential for ...
Tetsuro eTamaki, Yoshiyasu eUchiyama, Maki eHirata, Hiroyuki eHashimoto, Nobuyuki eNakajima, Kosuke eSaito, Toshiro eTerachi, Joji eMochida   +7 more
doaj   +1 more source

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source