Results 1 to 10 of about 92,602 (142)

Transcription factors Krüppel-like factor 4 and paired box 5 regulate the expression of the Grainyhead-like genes.

PLoS ONE, 2021
Genes from the Grainyhead-like (GRHL) family code for transcription factors necessary for the development and maintenance of various epithelia. These genes are also very important in the development of many types of cancer. However, little is known about
Grzegorz Kotarba, Agnieszka Taracha-Wisniewska, Michal Miller, Michal Dabrowski, Tomasz Wilanowski   +4 more
doaj   +6 more sources

Paired Box 9 (PAX9), the RNA polymerase II transcription factor, regulates human ribosome biogenesis and craniofacial development.

PLoS Genetics, 2020
Dysregulation of ribosome production can lead to a number of developmental disorders called ribosomopathies. Despite the ubiquitous requirement for these cellular machines used in protein synthesis, ribosomopathies manifest in a tissue-specific manner ...
Katherine I Farley-Barnes, Engin Deniz, Maya M Overton, Mustafa K Khokha, Susan J Baserga   +4 more
doaj   +5 more sources

Epigenetic, Genetic, and Functional Germline Alterations of PAX Genes in Human Pathology: A Comprehensive Update [PDF]

Current Issues in Molecular Biology
Paired box (PAX) genes encode a family of nine transcription factors that function as master regulators of embryogenesis, organogenesis, and lineage specification.
Valentina Lopez Gomez, Samantha Wegner, Stephanie Ocejo, Dezaray Perez, Diana Jabbour, Virginia Fernandez, Amr Abulaban, Marwan Bahmad, Tarec K. Elajami, Wassim Abou-Kheir, Hisham F. Bahmad   +10 more
doaj   +2 more sources

Chromosomal translocations involving paired box transcription factors in human cancer

International Journal of Biochemistry and Cell Biology, 1997
The PAX genes encode a family of transcription factors that control development within the neural, myogenic, lymphoid, and a variety of other lineages. These proteins are postulated to regulate expression of gene products that function in the control of cellular processes are fundamental to the development of cancer, and thus genetic alterations of ...
Frédéric Barr, F G Barr
exaly   +3 more sources

Bacterial Lipopolysaccharide Stimulates the Thyrotropin-Dependent Thyroglobulin Gene Expression at the Transcriptional Level by Involving the Transcription Factors Thyroid Transcription Factor-1 and Paired Box Domain Transcription Factor 8 [PDF]

Endocrinology, 2006
The bacterial lipopolysaccharide (LPS) is a biological activator that induces expression of multiple genes in several cell types. LPS has been proposed as an etiopathogenic agent in autoimmune diseases. However, whether LPS affects the expression of autoantigens has not been explored.
Edna T Kimura, Santisteban P, Laura Fozzatti   +2 more
exaly   +4 more sources

Prevention of Bone Loss after Ovariectomy in Mice with Preferential Overexpression of the Transcription Factor Paired Box-5 in Osteoblasts

Biological and Pharmaceutical Bulletin, 2013
We have recently shown that the transcription factor Paired box-5 (Pax5) promotes bone formation in vivo and osteoblastogenesis in vitro. Here, we demonstrated the involvement of Pax5 in bone remodeling after ovariectomy (OVX). A significant increase was seen in vertebrae bone volume in transgenic mice preferentially overexpressing Pax5 in osteoblasts ...
Eiichi Hinoi, Yukio Yoneda, Takashi Iezaki   +2 more
exaly   +4 more sources

The effects of transcription factor 7-like 2 rs7903146 and paired box 4 rs2233580 variants associated with type 2 diabetes on the therapeutic efficacy of hypoglycemic agents

Heliyon
This study aims to investigate the effects of the TCF7L2 rs7903146 and PAX4 rs2233580 (R192H) variants associated with T2D on the therapeutic efficacies of various HAs in patients with T2D after follow-up for 3 years.A total of 526 patients who were followed up at the Diabetic Clinic of Siriraj Hospital during 2016-2019 were enrolled.
Nattachet Plengvidhya, Pa-Thai Yenchitsomanus, Watip Tangjittipokin   +2 more
exaly   +4 more sources

An overview of PAX1: Expression, function and regulation in development and diseases

Frontiers in Cell and Developmental Biology, 2022
Transcription factors play multifaceted roles in embryonic development and diseases. PAX1, a paired-box transcription factor, has been elucidated to play key roles in multiple tissues during embryonic development by extensive studies.
Weiyin Wu, Xiangjun Kong, Yanhan Jia, Yihui Jia, Weimei Ou, Cuilian Dai, Gang Li, Rui Gao   +7 more
doaj   +1 more source

Chemical Synthesis of the PAX Protein Inhibitor EG1 and Its Ability to Slow the Growth of Human Colorectal Carcinoma Cells

Frontiers in Oncology, 2021
Colorectal cancer is primarily a disease of the developed world. The incidence rate has continued to increase over time, reflecting both demographic and lifestyle changes, which have resulted in genomic and epigenomic modifications.
Lorissa McDougall, Jui Thiang Brian Kueh, Jake Ward, Joel D. A. Tyndall, Joel D. A. Tyndall, Adele G. Woolley, Adele G. Woolley, Adele G. Woolley, Sunali Mehta, Sunali Mehta, Sunali Mehta, Cherie Stayner, David S. Larsen, Michael R. Eccles, Michael R. Eccles, Michael R. Eccles   +15 more
doaj   +1 more source

Dynamic DNA 5-hydroxylmethylcytosine and RNA 5-methycytosine Reprogramming During Early Human Development

Genomics, Proteomics & Bioinformatics, 2023
After implantation, complex and highly specialized molecular events render functionally distinct organ formation, whereas how the epigenome shapes organ-specific development remains to be fully elucidated.
Xiao Han, Jia Guo, Mengke Wang, Nan Zhang, Jie Ren, Ying Yang, Xu Chi, Yusheng Chen, Huan Yao, Yong-Liang Zhao, Yun-Gui Yang, Yingpu Sun, Jiawei Xu   +12 more
doaj   +1 more source