Results 1 to 10 of about 5,703 (146)

Rare germline genetic variation in PAX8 transcription factor binding sites and susceptibility to epithelial ovarian cancer [PDF]

American Journal of Epidemiology
Abstract Common genetic variation throughout the genome and rare coding variants identified to date explain about half of the inherited genetic component of epithelial ovarian cancer risk. It is likely that rare variation in the noncoding genome will explain some of the unexplained heritability, but identifying such variants is ...
Simon Gayther, Paul Pharoah, Michelle Jones   +2 more
exaly   +4 more sources

The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17 [PDF]

Science Signaling, 2022
PAX8 is a master transcription factor that is essential during embryogenesis and promotes neoplastic growth. It is expressed by the secretory cells lining the female reproductive tract, and its deletion during development results in atresia of reproductive tract organs.
Chaves-Moreira D, Cristina B Arruza-Frau, Simone Sidoli   +2 more
exaly   +4 more sources

SOX17/PAX8 dual immunohistochemical expression in the diagnosis of Müllerian carcinomas [PDF]

Diagnostic Pathology
Background Metastatic Müllerian carcinomas, including endometrial and ovarian adenocarcinomas, are challenging to diagnose due to factors like similar malignancies, insufficient clinical history, multiorgan dissemination, and small tumor specimens ...
Manar Moustafa, Marwa Ahmed Mohamed Abdalrahman, Heba Mahmoud Abdelgeleel   +2 more
doaj   +2 more sources

Thyroid Transcription Factor 1 Rescues PAX8/p300 Synergism Impaired by a Natural PAX8 Paired Domain Mutation with Dominant Negative Activity [PDF]

Molecular Endocrinology, 2005
AbstractMutations in the paired domain transcription factor PAX8 are a rare cause of congenital hypothyroidism due to thyroid dysgenesis. We identified a novel and unique PAX8 mutation segregating in seven affected members of a three-generations family.
Samuel Refetoff, Helmut Graßberger, Abramowicz Marc   +2 more
exaly   +4 more sources

Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors [PDF]

Development (Cambridge), 2004
The vertebrate inner ear arises from an ectodermal thickening, the otic placode, that forms adjacent to the presumptive hindbrain. Previous studies have suggested that competent ectodermal cells respond to Fgf signals from adjacent tissues and express two highly related paired box transcription factors Pax2a and Pax8 in the developing placode.
Stefan Hans, Monte Westerfield, Westerfield Monte   +2 more
exaly   +3 more sources

ASPSCR1: TFE3 Fusion‐Positive Epithelioid Angiomyolipoma/PEComa Lacking Melanocytic Markers: A Case Report [PDF]

IJU Case Reports
Introduction Epithelioid angiomyolipoma is a rare perivascular epithelioid cell tumor subtype with malignant potential. Its morphology mimics renal cell carcinoma, posing diagnostic challenges.
Yuka Kondo, Yoji Nagashima, Kenji Zennami, Megumi Sato, Sayaka Sumiyoshi, Akihiko Sugimoto, Madoka Isomura, Kiyoshi Takahara, Sachiko Minamiguchi   +8 more
doaj   +2 more sources

Genetic analysis of the paired box transcription factor (PAX8) gene in a cohort of Polish patients with primary congenital hypothyroidism and dysgenetic thyroid glands

Journal of Pediatric Endocrinology and Metabolism, 2015
AbstractThe morphological and biochemical phenotype ofSome 48 children (37 girls and 11 boys) with CH associated with thyroid ectopy (n=22), agenesis (n=10), hypoplasia (n=6), or thyroid dysgenesis of unknown cause (n=10) were enrolled. The study participants were born in south-eastern Poland in the years 1993–2012 and were selected for neonatal mass ...
Kumorowicz-Czoch, Małgorzata, Madetko-Talowska, Anna, Dudek, Adam, Tylek-Lemańska, Dorota   +3 more
exaly   +5 more sources

Clinicopathological Relevance of PAX8 Expression Patterns in Acute Kidney Injury and Chronic Kidney Diseases

Diagnostics, 2022
Transcription factor PAX8, expressed during embryonic kidney development, has been previously detected in various kidney tumors. In order to investigate expression of PAX8 transcription factor in acute kidney injury (AKI) and chronic kidney diseases (CKD)
Maja Zivotic, Dusko Dundjerovic, Radomir Naumovic, Sanjin Kovacevic, Milan Ivanov, Danijela Karanovic, Gorana Nikolic, Jasmina Markovic-Lipkovski, Sanja Radojevic Skodric, Jelena Nesovic Ostojic   +9 more
doaj   +1 more source

Neuropilin-2 Is a Newly Identified Target of PAX8 in Thyroid Cells. [PDF]

PLoS ONE, 2015
PAX8 is a transcription factor essential for thyroid gland development, as well as for the maintenance of the thyroid differentiated state in the adult.
Valeria Lucci, Tina Di Palma, Mariastella Zannini   +2 more
doaj   +1 more source

Identification of novel Pax8 targets in FRTL-5 thyroid cells by gene silencing and expression microarray analysis. [PDF]

PLoS ONE, 2011
The differentiation program of thyroid follicular cells (TFCs), by far the most abundant cell population of the thyroid gland, relies on the interplay between sequence-specific transcription factors and transcriptional coregulators with the basal ...
Tina Di Palma, Anna Conti, Tiziana de Cristofaro, Serena Scala, Lucio Nitsch, Mariastella Zannini   +5 more
doaj   +1 more source