Results 31 to 40 of about 5,722 (164)
Genomics, Proteomics & Bioinformatics, 2023 After implantation, complex and highly specialized molecular events render functionally distinct organ formation, whereas how the epigenome shapes organ-specific development remains to be fully elucidated.
Xiao Han +12 more
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Genome-wide analysis of Pax8 binding provides new insights into thyroid functions
BMC Genomics, 2012 Background The transcription factor Pax8 is essential for the differentiation of thyroid cells. However, there are few data on genes transcriptionally regulated by Pax8 other than thyroid-related genes.
Ruiz-Llorente Sergio +8 more
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The nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal caps [PDF]
BMC Developmental Biology, 2011 AbstractBackgroundThe three distinct types of kidneys, pronephros, mesonephros and metanephros, develop consecutively in vertebrates. The earliest form of embryonic kidney, the pronephros, is derived from intermediate mesoderm and the first expressed genes localized in the pronephros anlage are the transcription factors osr1, osr2, hnf1b, lhx1 and pax8,
Drews, Christiane +2 more
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IMMUNOHISTOCHEMICAL EXPRESSIONS OF PAX8 IN OVARIAN SURFACE EPITHELIAL TUMORS
The Iraqi Journal of Medical Sciences, 2018 Background: PAX8 is a nuclear transcription factor with limited expression in normal and neoplastic tissues, it has the potential to induce tumorigenesis and is expressed in a tissue during neoplastic transformation.
Samar Al-Shami, Ban Qasim, Ahmed Hassan
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Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations. [PDF]
PLoS Genetics, 2018 PAX5, one of nine members of the mammalian paired box (PAX) family of transcription factors, plays an important role in B cell development. Approximately one-third of individuals with pre-B acute lymphoblastic leukemia (ALL) acquire heterozygous ...
Matthew R Hart +5 more
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Role of Pax8 transcriptional factor in the differentiated thyroid [PDF]
, 2010 In Pax8-/- mice the thyroid anlage disappears around E11.5. At birth the gland appears as a rudimentary structure composed only of C cells while thyroid follicular cells are undetectable. Thus, this model does not allow the study of Pax8 function in the postnatal thyroid. To address the role of Pax8 in the differentiated thyroid, I established novel
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Disease Models & Mechanisms, 2020 Humans and mice have cyclical regeneration of the endometrial epithelium. It is expected that such regeneration is ensured by tissue stem cells, but their location and hierarchy remain debatable.
Dah-Jiun Fu +6 more
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Diagnostic Pathology, 2023 Background Only one thyroid follicular cell-derived tumor with a purely trabecular growth pattern has previously been described. This report aims to describe the histological, immunohistochemical, and molecular findings of our second case, propose a ...
Mitsuyoshi Hirokawa +8 more
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The Functional Interaction between the Paired Domain Transcription Factor Pax8 and Smad3 Is Involved in Transforming Growth Factor-β Repression of the Sodium/Iodide Symporter Gene [PDF]
Journal of Biological Chemistry, 2004 Transforming growth factor-beta (TGF-beta) is a secreted protein that regulates proliferation, differentiation, and death in various cell types, including thyroid cells, although few details are known about its mechanisms of action in this cell type.
Costamagna, Eugenia +2 more
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DNA Methylation and Expression Profiles of Whole Blood in Parkinson’s Disease
Frontiers in Genetics, 2021 Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease. It is presently only accurately diagnosed at an advanced stage by a series of motor deficits, which are predated by a litany of non-motor symptoms manifesting over ...
Adrienne R. Henderson +9 more
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