Results 21 to 30 of about 5,722 (164)

Expression of PAX8 Target Genes in Papillary Thyroid Carcinoma. [PDF]

PLoS ONE, 2016
PAX8 is a thyroid-specific transcription factor whose expression is dysregulated in thyroid cancer. A recent study using a conditional knock-out mouse model identified 58 putative PAX8 target genes. In the present study, we evaluated the expression of 11
Francesca Rosignolo, Marialuisa Sponziello, Cosimo Durante, Cinzia Puppin, Catia Mio, Federica Baldan, Carla Di Loreto, Diego Russo, Sebastiano Filetti, Giuseppe Damante   +9 more
doaj   +1 more source

The Paired Domain-containing Factor Pax8 and the Homeodomain-containing Factor TTF-1 Directly Interact and Synergistically Activate Transcription [PDF]

Journal of Biological Chemistry, 2003
Pax genes encode for transcription factors essential for tissue development in many species. Pax8, the only member of the family expressed in the thyroid tissue, is involved in the morphogenesis of the gland and in the transcriptional regulation of thyroid-specific genes.
DI PALMA T., NITSCH R., MASCIA A., NITSCH, LUCIO, DI LAURO, ROBERTO, ZANNINI M.   +5 more
openaire   +6 more sources

Comparative genomics reveals a functional thyroid-specific element in the far upstream region of the PAX8 gene

BMC Genomics, 2010
Background The molecular mechanisms leading to a fully differentiated thyrocite are still object of intense study even if it is well known that thyroglobulin, thyroperoxidase, NIS and TSHr are the marker genes of thyroid differentiation.
De Felice Mario, Abbondante Serena, de Cristofaro Tiziana, di Gennaro Alessandra, Di Dato Valeria, Nitsch Roberto, Zannini Mariastella, Di Lauro Roberto   +7 more
doaj   +1 more source

The Paired-Domain Transcription Factor Pax8 Binds to the Upstream Enhancer of the Rat Sodium/Iodide Symporter Gene and Participates in Both Thyroid-Specific and Cyclic-AMP-Dependent Transcription [PDF]

Molecular and Cellular Biology, 1999
The gene encoding the Na/I symporter (NIS) is expressed at high levels only in thyroid follicular cells, where its expression is regulated by the thyroid-stimulating hormone via the second messenger, cyclic AMP (cAMP). In this study, we demonstrate the presence of an enhancer that is located between nucleotides -2264 and -2495 in the 5'-flanking region
OHNO M., ZANNINI M., LEVY O., CARRASCO N., DI LAURO, ROBERTO   +4 more
  +8 more sources

WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8 [PDF]

Biochemical Journal, 2004
The Pax gene family encodes transcription factors that are essential in organogenesis and in the differentiation of various organs in higher eukaryotes. Pax proteins have a DNA binding domain at the N-terminus, and a transcriptional activation domain at the C-terminus.
Nitsch R, Di Palma T, Mascia A, Zannini M.   +3 more
openaire   +3 more sources

Evaluation of PAX8 expression promotes the proliferation of stomach Cancer cells

BMC Molecular and Cell Biology, 2019
Background PAX8 was not only a mitotic factor, but identified as a transcription factor involved in the prognosis of human tumor patients. Elucidating the function of PAX8 on the pathology of stomach cancer was meaningful.
Liang-Yu Bie, Ning Li, Wen-Ying Deng, Xiao-Yu Lu, Ping Guo, Su-Xia Luo   +5 more
doaj   +1 more source

Hormonal control of the transcription factor Pax8 and its role in the regulation of thyroglobulin gene expression in thyroid cells [PDF]

Journal of Endocrinology, 2002
The transcription factor Pax8 plays an important role in the expression of the differentiated phenotype of thyroid follicular cells. It has recently been shown that Pax8 is necessary for thyroglobulin (Tg) gene expression in the fully differentiated rat thyroid cell line PC. We have used the PC model system to investigate the role of Pax8 as a mediator
MASCIA A, NITSCH L, DI LAURO R, ZANNINI, MARIASTELLA   +3 more
openaire   +6 more sources

9.IMMUNOHISTOCHEMICAL EXPRESSIONS OF PAX8 IN OVARIAN SURFACE EPITHELIAL TUMORS

The Iraqi Journal of Medical Sciences, 2018
Background: PAX8 is a nuclear transcription factor with limited expression in normal and neoplastic tissues, it has the potential to induce tumorigenesis and is expressed in a tissue during neoplastic transformation.
Samar A. Al-Shami, Ban J. Qasim, Ahmed M. Hassan   +2 more
doaj   +6 more sources

Novel non-synonymous mutations of PAX8 in a cohort of Chinese with congenital hypothyroidism

Chinese Medical Journal, 2019
. Background:. The transcription factor paired box 8 (PAX8) was associated with type 2 congenital non-goitrous hypothyroidism (CHNG2), a clinical phenotype of congenital hypothyroidism (CH). Though studied in a few regions with different ethnicities, the
Fang Qian, Gui-Yu Li, Xiang-Jun Wu, Qin Jia, Guan-Ting Lyu, Man-Li Wang, Jun Wang, Xin Chen   +7 more
doaj   +1 more source

PAX 8 positive synovial sarcoma

Human Pathology: Case Reports, 2021
In this report, we describe a case of a biphasic tumour which presented as an incidental lump on the wrist of a 78 year old female. The epithelioid component predominated and was strikingly “gland-like”, and in an elderly female raised concerns of a ...
Miriam Fewtrell, Patricia Symons, Angela M. Hong, Peter Luk, Roland Jiang   +4 more
doaj   +1 more source