Results 11 to 20 of about 5,722 (164)

Functional Inactivation of the Transcription Factor Pax8 through Oligomerization Chain Reaction [PDF]

Molecular Endocrinology, 2006
Among the approaches used to provide a functional inactivation of a target protein, we have chosen the recently described oligomerization chain reaction (OCR) strategy to functionally inactivate the transcription factor Pax8, a member of the Pax gene family expressed in thyroid cells.
D'Andrea B., Iacone R., Di Palma T., Nitsch R., Baratta M. G., Nitsch L., Di Lauro R., Zannini M.   +7 more
openaire   +5 more sources

PAX8 and MECOM are interaction partners driving ovarian cancer

Nature Communications, 2021
Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and ...
Melusine Bleu, Fanny Mermet-Meillon, Verena Apfel, Louise Barys, Laura Holzer, Marianne Bachmann Salvy, Rui Lopes, Inês Amorim Monteiro Barbosa, Cecile Delmas, Alexandra Hinniger, Suzanne Chau, Markus Kaufmann, Simon Haenni, Karolin Berneiser, Maria Wahle, Ivana Moravec, Alexandra Vissières, Tania Poetsch, Erik Ahrné, Nathalie Carte, Johannes Voshol, Elisabeth Bechter, Jacques Hamon, Marco Meyerhofer, Dirk Erdmann, Matteo Fischer, Therese Stachyra, Felix Freuler, Sascha Gutmann, César Fernández, Tobias Schmelzle, Ulrike Naumann, Guglielmo Roma, Kate Lawrenson, Cristina Nieto-Oberhuber, Amanda Cobos-Correa, Stephane Ferretti, Dirk Schübeler, Giorgio Giacomo Galli   +38 more
doaj   +1 more source

HBx regulates transcription factor PAX8 stabilization to promote the progression of hepatocellular carcinoma [PDF]

Oncogene, 2019
Transcription factor PAX8 expression is upregulated in several types of cancers. However, little is known about the function of PAX8 in the progression of hepatoma and its regulatory mechanisms. Here, we show that PAX8 silencing inhibits the proliferation and clonogenicity of hepatoma cells and its growth in vivo.
Juan, Wang, Ning, Li, Ze-Bing, Huang, Sha, Fu, Song-Man, Yu, Yong-Ming, Fu, Peng-Cheng, Zhou, Ruo-Chan, Chen, Rong-Rong, Zhou, Yan, Huang, Xing-Wang, Hu, Xue-Gong, Fan   +11 more
openaire   +2 more sources

Sox9 is involved in the thyroid differentiation program and is regulated by crosstalk between TSH, TGFβ and thyroid transcription factors

Scientific Reports, 2022
While the signaling pathways and transcription factors involved in the differentiation of thyroid follicular cells, both in embryonic and adult life, are increasingly well understood, the underlying mechanisms and potential crosstalk between the thyroid ...
Arístides López-Márquez, Carlos Carrasco-López, Andrea Martínez-Cano, Pascale Lemoine, Christophe E. Pierreux, Pilar Santisteban   +5 more
doaj   +1 more source

PBRM1 loss in kidney cancer unbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation

Cell Reports, 2021
Summary: PBRM1, a subunit of the PBAF coactivator complex that transcription factors use to activate target genes, is genetically inactivated in almost all clear cell renal cell cancers (RCCs).
Xiaorong Gu, Francis Enane, Rita Tohme, Caroline Schuerger, Tomas Radivoyevitch, Yvonne Parker, Eric Zuberi, Bartlomiej Przychodzen, Babal Kant Jha, Daniel Lindner, Brian Rini, Yogen Saunthararajah   +11 more
doaj   +1 more source

Thyroid transcription factor 1 and Pax8 synergistically activate the promoter of the human thyroglobulin gene [PDF]

Journal of Molecular Endocrinology, 2001
Thyroglobulin (Tg) is an essential thyroid-specific protein, which serves as the matrix for thyroid hormone biosynthesis. To obtain new insights in the regulation of Tg gene expression, we investigated the interaction of the human Tg promoter with the thyroid-specific transcription factors TTF-1 and Pax8.
C R, Espinoza, T L, Schmitt, U, Loos
openaire   +2 more sources

Th1 immune maturation effects of

Science Progress, 2022
Nocardia rubra cell-wall skeleton (Nr-CWS) is reported as an external immunotherapeutic enhancer with the advantage of antitumor effect on human cancers. However, the immune regulatory role of Nr-CWS is not fully illustrated.
Meixiang Zhou, Shuping Zhou, Kun Han, Jie Zhang, Qingyu Chen, Cong Tian, Hongling Zhu, Mengyi Jiang, Daliu Min   +8 more
doaj   +1 more source

GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors

Cell & Bioscience, 2023
Background Loss of the transcription factor GLI-Similar 3 (GLIS3) function causes congenital hypothyroidism (CH) in both humans and mice due to decreased expression of several thyroid hormone (TH) biosynthetic genes in thyroid follicular cells.
Hong Soon Kang, Sara A. Grimm, Raja Jothi, Pilar Santisteban, Anton M. Jetten   +4 more
doaj   +1 more source

The Expression of Transcription Factors in Fetal Lamb Kidney

Journal of Developmental Biology, 2021
(1) Background: Renal development involves frequent expression and loss of transcription factors, resulting in the activation of genes. Wilms’ tumor 1 (WT1), hepatocyte nuclear factor-1-beta (HNF1β), and paired box genes 2 and 8 (Pax2 and Pax8) play an ...
Yuri Nishiya, Kohei Kawaguchi, Kosuke Kudo, Takuya Kawaguchi, Juma Obayashi, Kunihide Tanaka, Kei Ohyama, Hideki Nagae, Shigeyuki Furuta, Yasuji Seki, Junki Koike, Kevin C. Pringle, Hiroaki Kitagawa   +12 more
doaj   +1 more source

Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms [PDF]

Modern Pathology, 2008
Thyroid-specific transcription factors, Pax8, TTF-1, and TTF-2, are crucial for thyroid organogenesis and differentiation. Compared with TTF-1, the other two markers have scarcely been investigated in surgical pathology. The goal of this study is to evaluate the expressions of these markers in thyroid tumors of the full spectrum of differentiation ...
Daisuke, Nonaka, Yunjia, Tang, Luis, Chiriboga, Michael, Rivera, Ronald, Ghossein   +4 more
openaire   +2 more sources