Results 51 to 60 of about 5,722 (164)
Mapping Causal Biology: Mendelian Randomization in the Era of Big Data
Med Research, EarlyView.Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen +10 more
wiley +1 more source
Low dose radiation regulates BRAF-induced thyroid cellular dysfunction and transformation
Cell Communication and Signaling, 2019 Background The existence of differentiated thyroid cells is critical to respond radioactive iodide treatment strategy in thyroid cancer, and loss of the differentiated phenotype is a trademark of iodide-refractive thyroid disease. While high-dose therapy
Neha Kaushik +9 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2022 Exposure to fine particulate matter (PM2.5) could damage multiple organs and systems. Recent epidemiological studies have shown that PM2.5 can disrupt dynamic balance of thyroid hormone (TH).
Siying Tang +10 more
doaj +1 more source
Environmental Toxicology, EarlyView.ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei +6 more
wiley +1 more source
Cancer Science, EarlyView.F3/TF‐high ovarian clear cell carcinoma exhibits an immune‐cold phenotype characterized by reduced immune‐cell fractions and attenuated cancer‐cell interferon programs, with frequent B7‐H4 co‐expression. Patient‐derived models show preclinical sensitivity to the TF‐directed antibody–drug conjugate tisotumab vedotin.
Yutaro Mori +7 more
wiley +1 more source
BET Proteins Regulate Expression of Osr1 in Early Kidney Development
Biomedicines, 2021 In utero renal development is subject to maternal metabolic and environmental influences affecting long-term renal function and the risk of developing chronic kidney failure and cardiovascular disease.
Janina Schreiber +6 more
doaj +1 more source
NF-κB p65 Subunit Mediates Lipopolysaccharide-Induced Na+/I−Symporter Gene Expression by Involving Functional Interaction with the Paired Domain Transcription Factor Pax8 [PDF]
Molecular Endocrinology, 2010 The Gram-negative bacterial endotoxin lipopolysaccharide (LPS) elicits a variety of biological responses. Na(+)/I(-) symporter (NIS)-mediated iodide uptake is the main rate-limiting step in thyroid hormonogenesis. We have recently reported that LPS stimulates TSH-induced iodide uptake.
Juan Pablo, Nicola +4 more
openaire +2 more sources
Cell Proliferation, EarlyView.Wt1 expressed in the MD mesenchyme promotes MD regression by inducing Wif1 and Osx transcription. In male mice, mesenchyme‐specific inactivation of Wt1 results in MD retention. ABSTRACT In mammals, Müllerian ducts (MDs) are the precursors of the female reproductive tract which regress in males during embryonic development.
Min Chen +12 more
wiley +1 more source
Current Advances of Molecular Biomarkers and Liquid Biopsies Techniques in Ovarian Cancer
Cancer Medicine, Volume 15, Issue 8, August 2026.ABSTRACT Ovarian cancer (OC) remains a lethal gynecological malignancy with challenges in early diagnosis, treatment monitoring, and overcoming drug resistance. Liquid biopsy, a noninvasive approach analyzing tumor‐derived components in bodily fluids, has emerged as a promising tool in OC management.
Jingxia Zhang +5 more
wiley +1 more source
Frontiers in Neuroanatomy, 2016 Balance orientation depends on the precise operation of the vestibular end organs and the vestibular ganglion neurons. Previous research on the assemblage of the neuronal network in the developing foetal vestibular organ has been limited to data from ...
Lejo Johnson Chacko +7 more
doaj +1 more source