Results 71 to 80 of about 5,722 (164)

lncRNA PAX8-AS1 suppresses cervical cancer development by regulating miR-675-3p/ axis

The International Journal of Biological Markers
Objective Cervical cancer (CC) is among the most prevalent malignancies globally. Public sequencing data indicate that PAX8-AS1 is associated with gynecological cancers, including CC, but its specific function and mechanism in cervical cancer remain ...
Xiayang Lu, Peng Song, Qingfen Chen
doaj   +1 more source

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling

Glia, Volume 74, Issue 6, June 2026.
Using pharmacogenetic approaches, Baldassarro et al. demonstrate that RXRγ suppresses the SHH signaling pathway in OPCs to ensure their efficient differentiation following T3 stimulation. Accordingly, Rxrg−/− OPCs displayed compromised differentiation which was normalized by the pharmacological inhibition of the hyperactive SHH pathway.
Vito Antonio Baldassarro, Quentin Brassart, Valérie Fraulob, Laura Calzà, Wojciech Krezel   +4 more
wiley   +1 more source

Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1

Stem Cell Reports, 2017
The clinical importance of anterior foregut endoderm (AFE) derivatives, such as thyrocytes, has led to intense research efforts for their derivation through directed differentiation of pluripotent stem cells (PSCs).
Keri Dame, Steven Cincotta, Alex H. Lang, Reeti M. Sanghrajka, Liye Zhang, Jinyoung Choi, Letty Kwok, Talitha Wilson, Maciej M. Kańduła, Stefano Monti, Anthony N. Hollenberg, Pankaj Mehta, Darrell N. Kotton, Laertis Ikonomou   +13 more
doaj   +1 more source

Effects of Di-(2-ethylhexyl) phthalate on thyroid in pubertal female rats and related mechanism

Asian Pacific Journal of Tropical Medicine, 2018
Objective: The quality of the tropical environment is directly related to the sustainable development of the economy, society and the health of people in the tropics.
Pu Shao, Te Liu, Meng Zhang, Na Li
doaj   +1 more source

Thyroid metastasis from ovarian clear cell carcinoma

Endocrinology, Diabetes & Metabolism Case Reports
A 56-year-old woman with cervical pain with a history of ovarian clear cell carcinoma stage IIIC was admitted to a primary care doctor. Ultrasonography revealed a microhyperechoic nodule in the thyroid gland and cervical lymph node enlargement, and fine ...
Rika Sasaki, Haruhiko Yamazaki, Eita Kumagai, Soji Toda, Aya Saito   +4 more
doaj   +1 more source

Initial clinical presentation of single soft tissue metastasis of medullary thyroid carcinoma without primary tumor in the thyroid gland

World Journal of Surgical Oncology, 2017
Background Single soft tissue metastasis of medullary thyroid carcinoma is extremely rare. In addition, several occult medullary thyroid carcinomas with distant metastasis were reported, but undetectable primary lesion at diagnosis was also extremely ...
Masanori Okamoto, Akira Takazawa, Kaoru Aoki, Yasuo Yoshimura, Hiroyuki Kato, Toshiaki Otsuki, Kazuma Maeno, Tomonobu Koizumi   +7 more
doaj   +1 more source

Perfluorooctanesulfonic acid (PFOS) disrupts cadherin-16 in the developing rat thyroid gland

Current Research in Toxicology
Perfluorooctanesulfonic acid (PFOS) can disrupt the thyroid hormone (TH) system in rodents, potentially affecting perinatal growth and neurodevelopment.
Nichlas Davidsen, Louise Ramhøj, Anne-Sofie Ravn Ballegaard, Anna Kjerstine Rosenmai, Cecillie Sofie Henriksen, Terje Svingen   +5 more
doaj   +1 more source

Wnt4 expression in thyroid cells is modulated by the transcription factor Pax8

, 2013
The transcription factor Pax8 is expressed during thyroid development and is involved in the morphogenesis of the thyroid gland and maintenance of the differentiated phenotype. To date, Pax8 has been shown to regulate all the genes that are considered markers of thyroid differentiation.
openaire  

Chromosomal rearrangements and the pathogenesis of differentiated thyroid cancer

Oncology Reviews, 2011
The majority of thyroid cancers arise from the follicular cells of the thyroid gland, which yield a wide variety of distinct morphotypes, ranging from relatively indolent lesions to the most malignant forms of cancer known.
Honey V. Reddi, Alicia Algeciras-Schimnich, Bryan McIver, Norman L. Eberhardt, Stefan K.G. Grebe   +4 more
doaj   +2 more sources

Ectopic Thyroid Tissue Presenting as an Anterior Mediastinal Mass in an Elderly Male

Current Medical Issues
A rare developmental defect called ectopic thyroid tissue (ETT) is caused by abnormal embryonic migration. Less than 1% of ectopic thyroid instances are mediastinal ETT, which might radiologically resemble malignant neoplasms.
Maureen Mushtaq, Anuja Sharma
doaj   +1 more source