Results 31 to 40 of about 92,701 (241)

Pax258 and Pax6 alternative splicing events in basal chordates and vertebrates: a focus on paired box domain

Frontiers in Genetics, 2015
Paired box transcription factors play important role in development and tissue morphogenesis. The number of Pax homologs varies among species studied so far, due to genome and gene duplications that have affected PAX family to a great extent.
Peter eFabian, Iryna eKozmikova, Zbynek eKozmik, Chrysoula N. Pantzartzi   +3 more
doaj   +1 more source

Evolutionary history of chordate PAX genes: dynamics of change in a complex gene family. [PDF]

PLoS ONE, 2013
Paired box (PAX) genes are transcription factors that play important roles in embryonic development. Although the PAX gene family occurs in animals only, it is widely distributed.
Vanessa Rodrigues Paixão-Côrtes, Francisco Mauro Salzano, Maria Cátira Bortolini   +2 more
doaj   +1 more source

The Expression of Transcription Factors in Fetal Lamb Kidney

Journal of Developmental Biology, 2021
(1) Background: Renal development involves frequent expression and loss of transcription factors, resulting in the activation of genes. Wilms’ tumor 1 (WT1), hepatocyte nuclear factor-1-beta (HNF1β), and paired box genes 2 and 8 (Pax2 and Pax8) play an ...
Yuri Nishiya, Kohei Kawaguchi, Kosuke Kudo, Takuya Kawaguchi, Juma Obayashi, Kunihide Tanaka, Kei Ohyama, Hideki Nagae, Shigeyuki Furuta, Yasuji Seki, Junki Koike, Kevin C. Pringle, Hiroaki Kitagawa   +12 more
doaj   +1 more source

KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas

PLoS ONE, 2022
Endometrioid endometrial carcinomas (EECs) are the most common histological subtype of uterine cancer. Late-stage disease is an adverse prognosticator for EEC.
Meghan L. Rudd, Nancy F. Hansen, Xiaolu Zhang, Mary Ellen Urick, Suiyuan Zhang, Maria J. Merino, National Institutes of Health Intramural Sequencing Center Comparative Sequencing Program, James C. Mullikin, Lawrence C. Brody, Daphne W. Bell   +9 more
doaj   +3 more sources

GLIS3 mediated by the Rap1/PI3K/AKT signal pathway facilitates real-ambient PM2.5 exposure disturbed thyroid hormone homeostasis regulation

Ecotoxicology and Environmental Safety, 2022
Exposure to fine particulate matter (PM2.5) could damage multiple organs and systems. Recent epidemiological studies have shown that PM2.5 can disrupt dynamic balance of thyroid hormone (TH).
Siying Tang, Daochuan Li, Hao Ding, Menghui Jiang, Yanjie Zhao, Dianke Yu, Rong Zhang, Wen Chen, Rui Chen, Yuxin Zheng, Jinmei Piao   +10 more
doaj   +1 more source

The Paired-box Homeodomain Transcription Factor Pax6 Binds to the Upstream Region of the TRAP Gene Promoter and Suppresses Receptor Activator of NF-κB Ligand (RANKL)-induced Osteoclast Differentiation [PDF]

Journal of Biological Chemistry, 2013
Osteoclast formation is regulated by balancing between the receptor activator of nuclear factor-κB ligand (RANKL) expressed in osteoblasts and extracellular negative regulatory cytokines such as interferon-γ (IFN-γ) and interferon-β (IFN-β), which can suppress excessive bone destruction.
Kogawa, M., Hisatake, K., Atkins, G., Findlay, D., Enoki, Y., Sato, T., Gray, P., Kanesaki-Yatsuka, Y., Anderson, P., Wada, S., Kato, N., Fukuda, A., Katayama, S., Tsujimoto, M., Yoda, T., Suda, T., Okazaki, Y., Matsumoto, M.   +17 more
openaire   +3 more sources

Sarcopenia and piscines: the case for indeterminate-growing fish as unique genetic model organisms in aging and longevity research.

Frontiers in Genetics, 2013
Sarcopenia and dynapenia pose significant problems for the aged, especially as life expectancy rises in developed countries. Current therapies are marginally efficacious at best, and barriers to breakthroughs in treatment may result from currently ...
Jacob M Froehlich, Zachary eFowler, Nicholas J Galt, Daniel L Smith, Daniel L Smith, Peggy R Biga, Peggy R Biga   +6 more
doaj   +1 more source

Fluorescence microscopy data on expression of Paired Box Transcription Factor 7 in skeletal muscle of APOBEC2 knockout mice

Data in Brief, 2018
The data presented in this article are related to the research articles entitled "APOBEC2 negatively regulates myoblast differentiation in muscle regeneration" and "Data supporting possible implication of APOBEC2 in self-renewal functions of myogenic stem satellite cells: toward understanding the negative regulation of myoblast differentiation ...
Hideaki Ohtsubo, Yusuke Sato, Yuji Matsuyoshi, Takahiro Suzuki, Wataru Mizunoya, Mako Nakamura, Ryuichi Tatsumi, Yoshihide Ikeuchi   +7 more
openaire   +3 more sources

Identification of novel Pax8 targets in FRTL-5 thyroid cells by gene silencing and expression microarray analysis. [PDF]

PLoS ONE, 2011
The differentiation program of thyroid follicular cells (TFCs), by far the most abundant cell population of the thyroid gland, relies on the interplay between sequence-specific transcription factors and transcriptional coregulators with the basal ...
Tina Di Palma, Anna Conti, Tiziana de Cristofaro, Serena Scala, Lucio Nitsch, Mariastella Zannini   +5 more
doaj   +1 more source

TRPM3_miR-204: a complex locus for eye development and disease

Human Genomics, 2020
First discovered in a light-sensitive retinal mutant of Drosophila, the transient receptor potential (TRP) superfamily of non-selective cation channels serve as polymodal cellular sensors that participate in diverse physiological processes across the ...
Alan Shiels
doaj   +1 more source