Results 11 to 20 of about 92,701 (241)

Increased paired box transcription factor 8 has a survival function in Glioma [PDF]

BMC Cancer, 2014
The molecular basis to overcome therapeutic resistance to treat glioblastoma remains unclear. The anti-apoptotic b cell lymphoma 2 (BCL2) gene is associated with treatment resistance, and is transactivated by the paired box transcription factor 8 (PAX8).
Hung, Noelyn, Chen, Yu-Jen, Taha, Ahmad, Olivecrona, Magnus, Boet, Ronald, Wiles, Anna, Warr, Tracy, Shaw, Alisha, Eiholzer, Ramona, Baguley, Bruce C., Eccles, Michael R., Braithwaite, Antony W., MacFarlane, Martin, Royds, Janice A., Slatter, Tania   +14 more
openaire   +3 more sources

Effect of palmitoleic acid on the differentiation of bovine skeletal muscle satellite cells

Journal of Animal Science and Technology, 2021
We hypothesized that the unsaturated fatty acid palmitoleic acid (POA) could promote the expression of adipogenic/lipogenic genes in bovine skeletal muscle satellite cells (BSCs). The BSCs were cultured in a growth
Junfang Zhang, Qiang Li, Kim Margarette Corpuz Nogoy, Jianfu Sun, Bin Sun, Ying Wang, Lin Tang, Jia Yu, Xin Jin, Xiangzi Li, Seong-Ho Choi   +10 more
doaj   +1 more source

Sequence characteristics and expression profiles of Pax-5 and Blimp-1 in Epinephelus coioides following parasite infection and bacterial vaccination

Aquaculture Reports, 2021
In mammals, the transcription factors paired box-5 (Pax-5) and B-lymphocyte-induced maturation protein-1 (Blimp-1) maintain strict command of B-cell differentiation from hematopoietic stem cells to plasma cells.
Qing Han, Rui Han, Xueli Lai, Jiule Wang, Yingtong Hu, Xiaochun Luo, Anxing Li, Zequan Mo, Yanwei Li, Xueming Dan   +9 more
doaj   +1 more source

Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR [PDF]

Oncogene, 2000
The aberrant expression of the transcription factors PAX3 and PAX3/FKHR associated with rhabdomyosarcoma (RMS), solid tumors displaying muscle cell features, suggests that these proteins play an important role in the pathogenesis of RMS. We could previously demonstrate that one of the oncogenic functions of PAX3 and PAX3/FKHR in RMS is protection from ...
MARGUE, Christiane, Bernasconi, Michele, Barr, Frederik, Schäfer, Beat   +3 more
openaire   +4 more sources

c-Abl Kinase Is Required for Satellite Cell Function Through Pax7 Regulation

Frontiers in Cell and Developmental Biology, 2021
Satellite cells (SCs) are tissue-specific stem cells responsible for adult skeletal muscle regeneration and maintenance. SCs function is critically dependent on two families of transcription factors: the paired box (Pax) involved in specification and ...
Fabián Montecino, Natalia González, Natasha Blanco, Manuel J. Ramírez, Adrián González-Martín, Alejandra R. Alvarez, Hugo Olguín   +6 more
doaj   +1 more source

MicroRNA regulation of the paired-box transcription factor Pax3 confers robustness to developmental timing of myogenesis [PDF]

Proceedings of the National Academy of Sciences, 2011
Commitment of progenitors in the dermomyotome to myoblast fate is the first step in establishing the body musculature. Pax3 is a crucial transcription factor, important for skeletal muscle development and expressed in myogenic progenitors in the dermomyotome of developing somites and in migratory muscle progenitors that populate the limb buds.
Goljanek-Whysall, Katarzyna, Sweetman, Dylan, Abu-Elmagd, Muhammad, Chapnik, Elik, Dalmay, Tamas, Hornstein, Eran, Munsterberg, Andrea   +6 more
openaire   +4 more sources

Cloning and Functional Analysis of Pax6 from the Hydrothermal Vent Tubeworm Ridgeia piscesae. [PDF]

PLoS ONE, 2016
The paired box 6 (Pax6) gene encodes a transcription factor essential for eye development in a wide range of animal lineages. Here we describe the cloning and characterization of Pax6 gene from the blind hydrothermal vent tubeworm Ridgeia piscesae ...
Huifang Yuan, Wei Wang, Bin Hu, Changkun Pan, Mingliang Chen, Linlin Ke, Lirong Yang, Jianming Chen   +7 more
doaj   +1 more source

PITX1 inhibits the growth and proliferation of melanoma cells through regulation of SOX family genes

Scientific Reports, 2021
Melanoma is one of the most aggressive types of cancer wherein resistance to treatment prevails. Therefore, it is important to discover novel molecular targets of melanoma progression as potential treatments.
Takahito Ohira, Suguru Nakagawa, Jumpei Takeshita, Hiroyuki Aburatani, Hiroyuki Kugoh   +4 more
doaj   +1 more source

Transcription Factor PAX6 (Paired Box 6) Controls Limbal Stem Cell Lineage in Development and Disease [PDF]

Journal of Biological Chemistry, 2015
PAX6 is a master regulatory gene involved in neuronal cell fate specification. It also plays a critical role in early eye field and subsequent limbal stem cell (LSC) determination during eye development. Defects in Pax6 cause aniridia and LSC deficiency in humans and the Sey (Small eye) phenotype in mice (Massé, K., Bhamra, S., Eason, R., Dale, N., and
Li, Gen, Xu, Fan, Zhu, Jie, Krawczyk, Michal, Zhang, Ying, Yuan, Jin, Patel, Sherrinal, Wang, Yujuan, Lin, Ying, Zhang, Ming, Cai, Huimin, Chen, Daniel, Zhang, Meixia, Cao, Guiqun, Yeh, Emily, Lin, Danni, Su, Qiao, Li, Wen-wen, Sen, George L, Afshari, Natalie, Chen, Shaochen, Maas, Richard L, Fu, Xiang-Dong, Zhang, Kang, Liu, Yizhi, Ouyang, Hong   +25 more
openaire   +4 more sources

MITF and PAX3 play distinct roles in melanoma cell migration; outline of a genetic switch theory involving MITF and PAX3 in proliferative and invasive phenotypes of melanoma

Frontiers in Oncology, 2013
Melanoma is a very aggressive neoplasm with a propensity to undergo progression and invasion early in its evolution. The molecular pathways underpinning invasion in melanoma are now just beginning to be elucidated, but a clear understanding of the ...
Michael R Eccles, Shujie eHe, Antonio eAhn, Lynn eSlobbe, Aaron R Jeffs, Han-Seung eYoon, Bruce C Baguley   +6 more
doaj   +1 more source