PAX3: A Driver of Normal Development and Disease [PDF]
BiomoleculesPAX3 plays a vital role in regulating proper growth, migration, differentiation, and survival during development of normal tissues, including those derived from the embryonic neural crest.
Noah B. Prince +3 more
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Pax3 stimulates p53 ubiquitination and degradation independent of transcription. [PDF]
PLoS ONE, 2011 Pax3 is a developmental transcription factor that is required for neural tube and neural crest development. We previously showed that inactivating the p53 tumor suppressor protein prevents neural tube and cardiac neural crest defects in Pax3-mutant mouse
Xiao Dan Wang +2 more
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Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo [PDF]
Cell ReportsSummary: Fusion-positive rhabdomyosarcoma is an aggressive pediatric cancer molecularly characterized by arrested myogenesis. The defining genetic driver, PAX3::FOXO1, encodes a chimeric gain-of-function transcription factor.
Jack Kucinski +8 more
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Unrevealing the dual role of paired box and sex determining region Y related high mobility group box in glioblastoma [PDF]
Discover OncologyThis narrative review summarises glioblastoma (GBM), a very frequent invasive kind of brain tumour in the elderly that is extremely aggressive, resistant to treatment, and has a bad prognosis because of its substantial genetic and cellular heterogeneity.
Kallol Polley, Sayed Mohammed Firdous
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PAX3 expression patterns in ocular surface melanocytes [PDF]
Scientific ReportsPAX3, a transcription factor essential for neural crest development and melanocyte progenitors, is expressed in various melanocytic tissues. However, its role in ocular surface tissues remains poorly understood.
Eva Ulrich +8 more
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The PAX3-FOXO1 fusion protein present in rhabdomyosarcoma interferes with normal FOXO activity and the TGF-β pathway. [PDF]
PLoS ONE, 2015 PAX3-FOXO1 (PAX3-FKHR) is the fusion protein produced by the genomic translocation that characterizes the alveolar subtype of Rhabdomyosarcoma, a pediatric sarcoma with myogenic phenotype. PAX3-FOXO1 is an aberrant but functional transcription factor. It
Michel Schmitt-Ney, Giovanni Camussi
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PAX3 expression in normal skin melanocytes and melanocytic lesions (naevi and melanomas). [PDF]
PLoS ONE, 2010 BackgroundCutaneous Malignant Melanoma is an aggressive form of skin cancer, arising in cutaneous melanocytes. The transcription factor PAX3 regulates melanocyte specification from neural crest cells during development but expression in differentiated ...
Sandra Medic, Mel Ziman
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Cyclin-dependent kinase 4 phosphorylates and positively regulates PAX3-FOXO1 in human alveolar rhabdomyosarcoma cells. [PDF]
PLoS ONE, 2013 Alveolar rhabdomyosarcoma (ARMS) is an aggressive childhood muscle sarcoma with a 5-year survival rate of less than 30%. More than 80% of ARMSs harbor a PAX3-FOXO1 fusion transcription factor.
Lingling Liu +3 more
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Pax3 and Hippo Signaling Coordinate Melanocyte Gene Expression in Neural Crest
Cell Reports, 2014 Summary: Loss of Pax3, a developmentally regulated transcription factor expressed in premigratory neural crest, results in severe developmental defects and embryonic lethality.
Lauren J. Manderfield +9 more
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Mechanisms contributing to differential regulation of PAX3 downstream target genes in normal human epidermal melanocytes versus melanoma cells. [PDF]
PLoS ONE, 2015 Melanoma is a highly aggressive and drug resistant form of skin cancer. It arises from melanocytes, the pigment producing cells of the skin. The formation of these melanocytes is driven by the transcription factor PAX3 early during embryonic development.
Danielle Bartlett +3 more
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