Results 21 to 30 of about 8,051 (168)

Generation of a conditional loxP allele of the Pax3 transcription factor that enables selective deletion of the homeodomain [PDF]

genesis, 2002
Pax3 is one of nine members of the paired-box-containing transcription factors (Stuart et al., 1994) and is widely expressed in many tissues and organs, including neural tube/neural crest and somites. Pax3 is located on human 2q35 and mouse 1(44.0cM) chromosomes and contains two structurally independent DNA-binding domains, the pairedand homeo-domains.
Srinagesh V, Koushik, Hongmei, Chen, Jian, Wang, Simon J, Conway   +3 more
openaire   +2 more sources

Two novel mutations of PAX3 and SOX10 were characterized as genetic causes of Waardenburg Syndrome

Molecular Genetics & Genomic Medicine, 2020
Background The objective of this study was to investigate the genetic causes of two probands diagnosed as Waardenburg syndrome (WS type I and IV) from two unrelated Chinese families. Methods PAX3 and SOX10 were the main pathogenic genes for WS type I (WS
Yongbo Yu, Wei Liu, Min Chen, Yang Yang, Yeran Yang, Enyu Hong, Jie Lu, Jun Zheng, Xin Ni, Yongli Guo, Jie Zhang   +10 more
doaj   +1 more source

Temporal Analysis of Gene Expression in the Murine Schwann Cell Lineage and the Acutely Injured Postnatal Nerve. [PDF]

PLoS ONE, 2016
Schwann cells (SCs) arise from neural crest cells (NCCs) that first give rise to SC precursors (SCPs), followed by immature SCs, pro-myelinating SCs, and finally, non-myelinating or myelinating SCs.
Anjali Balakrishnan, Morgan G Stykel, Yacine Touahri, Jo Anne Stratton, Jeff Biernaskie, Carol Schuurmans   +5 more
doaj   +1 more source

Carnitine palmitoyltransferase 1A (CPT1A): a transcriptional target of PAX3-FKHR and mediates PAX3-FKHR–dependent motility in alveolar rhabdomyosarcoma cells

BMC Cancer, 2012
Background Alveolar rhabdomyosarcoma (ARMS) has a high propensity to metastasize, leading to its aggressiveness and a poor survival rate among those with the disease. More than 80% of aggressive ARMSs harbor a PAX3-FKHR fusion transcription factor, which
Liu Lingling, Wang Yong-Dong, Wu Jing, Cui Jimmy, Chen Taosheng   +4 more
doaj   +1 more source

Itm2a is a Pax3 target gene, expressed at sites of skeletal muscle formation in vivo. [PDF]

PLoS ONE, 2013
The paired-box homeodomain transcription factor Pax3 is a key regulator of the nervous system, neural crest and skeletal muscle development. Despite the important role of this transcription factor, very few direct target genes have been characterized. We
Mounia Lagha, Alicia Mayeuf-Louchart, Ted Chang, Didier Montarras, Didier Rocancourt, Antoine Zalc, Jay Kormish, Kenneth S Zaret, Margaret E Buckingham, Frederic Relaix   +9 more
doaj   +1 more source

Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mesoderm.

PLoS Biology, 2019
The transcriptional mechanisms driving lineage specification during development are still largely unknown, as the interplay of multiple transcription factors makes it difficult to dissect these molecular events.
Alessandro Magli, June Baik, Lauren J Mills, Il-Youp Kwak, Bridget S Dillon, Ricardo Mondragon Gonzalez, David A Stafford, Scott A Swanson, Ron Stewart, James A Thomson, Daniel J Garry, Brian D Dynlacht, Rita C R Perlingeiro   +12 more
doaj   +1 more source

BET Bromodomain Degradation Disrupts Function but Not 3D Formation of RNA Pol2 Clusters

Pharmaceuticals, 2023
Fusion-positive rhabdomyosarcoma (FP-RMS) is driven by a translocation that creates the chimeric transcription factor PAX3-FOXO1 (P3F), which assembles de novo super enhancers to drive high levels of transcription of other core regulatory transcription ...
Diana H. Chin, Issra Osman, Jadon Porch, Hyunmin Kim, Kristen K. Buck, Javier Rodriguez, Bianca Carapia, Deborah Yan, Stela B. Moura, Jantzen Sperry, Jonathan Nakashima, Kasey Altman, Delsee Altman, Berkley E. Gryder   +13 more
doaj   +1 more source

KDM3A/Ets1 epigenetic axis contributes to PAX3/FOXO1‐driven and independent disease‐promoting gene expression in fusion‐positive Rhabdomyosarcoma

Molecular Oncology, 2020
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and young adults. RMS exists as two major disease subtypes, oncofusion‐negative RMS (FN‐RMS) and oncofusion‐positive RMS (FP‐RMS). FP‐RMS is characterized by recurrent PAX3/7‐FOXO1
Lays M. Sobral, Hannah M. Hicks, Janet K. Parrish, Tyler S. McCann, Joseph Hsieh, Andrew Goodspeed, James C. Costello, Joshua C. Black, Paul Jedlicka   +8 more
doaj   +1 more source

Pax3 induces differentiation of juvenile skeletal muscle stem cells without transcriptional upregulation of canonical myogenic regulatory factors [PDF]

Journal of Cell Science, 2010
Pax3 is an essential myogenic regulator of fetal and embryonic development, but its role in postnatal myogenesis remains a topic of debate. We show that constitutive expression of Pax3 in postnatal, juvenile mouse skeletal muscle stem cells, a subset of the heterogeneous satellite cell pool highly enriched for myogenic activity, potently induces ...
Young, A. P., Wagers, Amy
openaire   +4 more sources

PAX3-FOXO1 Induces Up-Regulation of Noxa Sensitizing Alveolar Rhabdomyosarcoma Cells to Apoptosis

Neoplasia: An International Journal for Oncology Research, 2013
Alveolar rhabdomyosarcoma (ARMS) has a much poorer prognosis than the more common embryonal subtype. Most ARMS tumors characteristically possess a specific genomic translocation between the genes of PAX3/7 and FOXO1 (FKHR), which forms fusion proteins ...
Amy D. Marshall, Fabrizio Picchione, Ramon I. Klein Geltink, Gerard C. Grosveld   +3 more
doaj   +1 more source