Results 51 to 60 of about 11,246 (181)

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Engineering Skeletal Muscle Grafts with PAX7::GFP-Sorted Human Pluripotent Stem Cell-Derived Myogenic Progenitors on Fibrin Microfiber Bundles for Tissue Regeneration

Bioengineering, 2022
Tissue engineering strategies that combine human pluripotent stem cell-derived myogenic progenitors (hPDMs) with advanced biomaterials provide promising tools for engineering 3D skeletal muscle grafts to model tissue development in vitro and promote ...
Sarah M. Somers, Jordana Gilbert-Honick, In Young Choi, Emily K. W. Lo, HoTae Lim, Shaquielle Dias, Kathryn R. Wagner, Hai-Quan Mao, Patrick Cahan, Gabsang Lee, Warren L. Grayson   +10 more
doaj   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Effect of an Exercise Training Course and Bone Marrow-Derived Stem Cell injection on Pax7 and Myogenin Expression in a Rat Model of Arthritis

Medical Laboratory Journal, 2020
Background and objectives: Osteoarthritis is one of the most common arthritic diseases and a main cause of pain and disability. Simultaneous downexpression of paired box 7 (Pax7) and myogenin genes, as indicators of satellite cells activation is evident ...
hassan rasouli, parvin farzanegi, hajar abbaszadeh   +2 more
doaj  

Integrated functions of Pax3 and Pax7 in the regulation of proliferation, cell size and myogenic differentiation.

PLoS ONE, 2009
Pax3 and Pax7 are paired-box transcription factors with roles in developmental and adult regenerative myogenesis. Pax3 and Pax7 are expressed by postnatal satellite cells or their progeny but are down regulated during myogenic differentiation.
Charlotte A Collins, Viola F Gnocchi, Robert B White, Luisa Boldrin, Ana Perez-Ruiz, Frederic Relaix, Jennifer E Morgan, Peter S Zammit   +7 more
doaj   +1 more source

Progression and Differentiation of Alveolar Rhabdomyosarcoma Is Regulated by PAX7 Transcription Factor—Significance of Tumor Subclones

Cells, 2021
Rhabdomyosarcoma (RMS), is the most frequent soft tissue tumor in children that originates from disturbances in differentiation process. Mechanisms leading to the development of RMS are still poorly understood. Therefore, by analysis of two RMS RH30 cell
Klaudia Skrzypek, Grażyna Adamek, Marta Kot, Bogna Badyra, Marcin Majka   +4 more
doaj   +1 more source

Melatonin improves muscle injury and differentiation by increasing Pax7 expression

International Journal of Biological Sciences, 2023
A balance between muscle injury and regeneration is critical for sustaining muscle function during myogenesis. Melatonin is well recognized for its involvement in neuroprotective activities, immune system regulation and suppression of inflammatory responses.
Su, Chen-Ming, Tsai, Chun-Hao, Chen, Hsien-Te, Wu, Yi-Syuan, Chang, Jun-Way, Yang, Shun-Fa, Tang, Chih-Hsin   +6 more
openaire   +2 more sources

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

PAX7 gene polymorphism in muscular temporomandibular disorders as potentially related to muscle stem cells

BMC Musculoskeletal Disorders, 2021
Background Temporomandibular disorders (TMD) are a group of painful and debilitating disorders, involving the masticatory muscles and/or the temporomandibular joint (TMJ).
Valquiria Quinelato, Letícia Ladeira Bonato, Alexandre Rezende Vieira, José Mauro Granjeiro, Karla Menezes, Radovan Borojevic, Priscila Ladeira Casado, Jose Albuquerque Calasans-Maia, Ricardo Tesch   +8 more
doaj   +1 more source

Development of the abdominal musculature in the chicken embryo

Journal of Anatomy, Volume 249, Issue 3, Page 618-633, September 2026.
In this study, we investigate anatomy, morphogenesis, segmental origin, and fiber formation of the abdominal musculature in the chicken embryo. We show that abdominal muscles arise from somites 24 to 28, and that the segmental identity of individual fibers in the abdominal muscle sheets is maintained.
Margarethe Draga, Luke Orth, Julia Khabyuk, Vanessa Holtwick, Johanna Heinen, Felicitas Pröls, Martin Scaal   +6 more
wiley   +1 more source