Results 71 to 80 of about 19,447 (222)

Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis [PDF]

The Journal of Cell Biology, 2006
We assessed viable Pax7−/− mice in 129Sv/J background and observed reduced growth and marked muscle wasting together with a complete absence of functional satellite cells. Acute injury resulted in an extreme deficit in muscle regeneration. However, a small number of regenerated myofibers were detected, suggesting the presence of residual myogenic cells
Kuang, Shihuan, Chargé, Sophie B., Seale, Patrick, Huh, Michael, Rudnicki, Michael A.   +4 more
openaire   +2 more sources

Progression and Differentiation of Alveolar Rhabdomyosarcoma Is Regulated by PAX7 Transcription Factor—Significance of Tumor Subclones

Cells, 2021
Rhabdomyosarcoma (RMS), is the most frequent soft tissue tumor in children that originates from disturbances in differentiation process. Mechanisms leading to the development of RMS are still poorly understood. Therefore, by analysis of two RMS RH30 cell
Klaudia Skrzypek, Grażyna Adamek, Marta Kot, Bogna Badyra, Marcin Majka   +4 more
doaj   +1 more source

Muscle Progenitors Derived from Extraocular Muscles Express Higher Levels of Neurotrophins and their Receptors than other Cranial and Limb Muscles [PDF]

, 2020
Extraocular muscles (EOMs) show resistance to muscle dystrophies and sarcopenia. It has been recently demonstrated that they are endowed with different types of myogenic cells, all of which present an outstanding regenerative potential. Neurotrophins are
Benítez Temiño, Beatriz, Carrero Rojas, Génova, Davis López de Carrizosa, María América, Pastor Loro, Ángel Manuel   +3 more
core   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Effect of an Exercise Training Course and Bone Marrow-Derived Stem Cell injection on Pax7 and Myogenin Expression in a Rat Model of Arthritis

Medical Laboratory Journal, 2020
Background and objectives: Osteoarthritis is one of the most common arthritic diseases and a main cause of pain and disability. Simultaneous downexpression of paired box 7 (Pax7) and myogenin genes, as indicators of satellite cells activation is evident ...
hassan rasouli, parvin farzanegi, hajar abbaszadeh   +2 more
doaj  

Integrated functions of Pax3 and Pax7 in the regulation of proliferation, cell size and myogenic differentiation.

PLoS ONE, 2009
Pax3 and Pax7 are paired-box transcription factors with roles in developmental and adult regenerative myogenesis. Pax3 and Pax7 are expressed by postnatal satellite cells or their progeny but are down regulated during myogenic differentiation.
Charlotte A Collins, Viola F Gnocchi, Robert B White, Luisa Boldrin, Ana Perez-Ruiz, Frederic Relaix, Jennifer E Morgan, Peter S Zammit   +7 more
doaj   +1 more source

Engineering Skeletal Muscle Grafts with PAX7::GFP-Sorted Human Pluripotent Stem Cell-Derived Myogenic Progenitors on Fibrin Microfiber Bundles for Tissue Regeneration

Bioengineering, 2022
Tissue engineering strategies that combine human pluripotent stem cell-derived myogenic progenitors (hPDMs) with advanced biomaterials provide promising tools for engineering 3D skeletal muscle grafts to model tissue development in vitro and promote ...
Sarah M. Somers, Jordana Gilbert-Honick, In Young Choi, Emily K. W. Lo, HoTae Lim, Shaquielle Dias, Kathryn R. Wagner, Hai-Quan Mao, Patrick Cahan, Gabsang Lee, Warren L. Grayson   +10 more
doaj   +1 more source

The occipital lateral plate mesoderm is a novel source for vertebrate neck musculature [PDF]

, 2010
In vertebrates, body musculature originates from somites, whereas head muscles originate from the cranial mesoderm. Neck muscles are located in the transition between these regions.
Christ, B., Harel, I., Huang, R., Otto, Anthony, Patel, Ketan, Pu, Q., Tajbakhsh, S., Theis, S., Tzahor, E., Valasek, Petr   +9 more
core   +1 more source

Functionally heterogeneous human satellite cells identified by single cell RNA sequencing. [PDF]

, 2020
Although heterogeneity is recognized within the murine satellite cell pool, a comprehensive understanding of distinct subpopulations and their functional relevance in human satellite cells is lacking.
Aguilar, Aizarani, Alexander, Alonso-Martin, Arpino, Arpke, Baker, Biernacka, Bigot, Boscher, Brooks, Butler, Chakkalakal, Chakkalakal, Charville, Cheung, Cho, Collins, Dell'Orso, Deng, Der Vartanian, Dumont, Elgort, Fan, Flint, Fukada, Garcia, Garcia, Gayraud-Morel, Gnocchi, Guruharsha, Gvaramia, Hai, Hurley, Inoue, Jiang, Kann, Karantza, Kuang, Kumar, Lee, Liu, Liu, Liu, Machado, Macosko, Mallaney, Marchand, Marti, Martinez, Mauro, Min, Moniot, Montarras, Mourkioti, Ng, Nicol, Ono, Pal, Pala, Pallafacchina, Pan, Pomerantz, Porpiglia, Qing, Qiu, Qiu, R Development Core Team, Rozkalne, Rubenstein, Ryall, Sacco, Satija, Scaramozza, Schiaffino, Schmidt, Schroder, Shea, Sheikh, Shen, Sherwood, Si, Siegel, Simeckova, Smith, Song, Sousa-Victor, Stark, Takahashi, Tierney, Trapnell, Tzioras, Uezumi, van Velthoven, Volonte, Wagner, Weinstein, Wu, Wu, Xu, Yang, Yeh, Yi, Yu, Yu, Zhang, Zheng   +106 more
core   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source