Results 71 to 80 of about 11,246 (181)
Aging Cell, Volume 25, Issue 8, August 2026.Skeletal muscle aging is associated with a decrease in expression of the lactate receptor GPR81. Treating senescent myoblasts in vitro and progeric mice in vivo with GPR81 agonist decreases intramyocellular lipid accumulation and reverses hallmarks of aging. ABSTRACT Skeletal muscle aging is associated with increased lipid accumulation, or myosteatosis,
Pihu Mehrotra +11 more
wiley +1 more source
Cell Reports, 2016 Pax7 is a nodal transcription factor that is essential for regulating the maintenance, expansion, and myogenic identity of satellite cells during both neonatal and adult myogenesis.
Alessandra Pasut +7 more
doaj +1 more source
Aging Cell, Volume 25, Issue 8, August 2026.As a critical bioactive component of Polygonatum sibiricum, diosgenin improves age‐related declines in skeletal muscle mass and function by activating the SIRT1/PGC‐1α pathway, upregulating the expression of the myokine METRNL and IGF‐1, and promoting satellite cell proliferation and myogenic differentiation.
Xin Zeng +9 more
wiley +1 more source
Acta Physiologica, Volume 242, Issue 8, August 2026.ABSTRACT Peripheral artery disease (PAD) is a progressive atherothrombotic disorder affecting more than 230 million people worldwide. Conventional animal models of chronic hindlimb ischemia (HLI) are highly invasive, technically challenging, fail to account for anatomical variation, and may not accurately recapitulate progressive PAD pathophysiology ...
Oliver Kitzerow +4 more
wiley +1 more source
Myonuclear Dynamics After Skeletal Muscle Surgical Injury
The FASEB Journal, Volume 40, Issue 14, 31 July 2026.Using a recombination‐independent doxycycline inducible model of timed nonsatellite cell‐derived myonuclear labeling in adult skeletal muscle, we show that resident myonuclei move and become displaced within intact muscle fibers after muscle surgical injury.
Micah Goeke +3 more
wiley +1 more source
A Myocyte‐Enriched Long Non‐Coding RNA NRMLncR Enhances Myogenesis in Mouse
The FASEB Journal, Volume 40, Issue 13, 15 July 2026.We identified a novel myocyte‐enriched, Notch‐repressed myogenic lncRNA, NRMLncR, that is induced by myogenic regulatory factors (MRFs) during myogenic progression in mouse. NRMLncR localizes to cytoplasmic and nuclear compartments, associates with the RNA‐binding protein CUGBP Elav‐like family member 1 (CELF1), and is linked to neighboring gene Tbx1 ...
Yufen Li +12 more
wiley +1 more source
MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
Nature Communications, 2019 PAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation.
Gregory C. Addicks +7 more
doaj +1 more source
PLoS ONEEssential for muscle fiber formation and hypertrophy, muscle stem cells, also called satellite cells, reside beneath the basal lamina of the muscle fiber.
Cécile Rallière +3 more
doaj +1 more source
Comparative expression analysis of Pax3 and Pax7 during mouse myogenesis
The International Journal of Developmental Biology, 2006 Pax3 and Pax7 are closely related transcription factors involved in the commitment of myogenic precursors in the developing trunk. However, it is not yet clear whether these genes are required for myogenic cell specification in the head and for post-somitic myogensis per se.
David, Horst +6 more
openaire +3 more sources
Skeletal Muscle, 2017 Background Facioscapulohumeral muscular dystrophy (FSHD) is most commonly inherited in an autosomal dominant pattern and caused by the abnormal expression of DUX4 in skeletal muscle.
Premi Haynes +3 more
doaj +1 more source