Results 41 to 50 of about 19,447 (222)
Pax7 reporter mouse models: a pocket guide for satellite cell research
European Journal of Translational Myology, 2023 Since their discovery, satellite cells have showcased their need as primary contributors to skeletal muscle maintenance and repair. Satellite cells lay dormant, but when needed, activate, differentiate, fuse to fibres and self-renew, that has bestowed ...
Huascar Pedro Ortuste Quiroga +2 more
doaj +1 more source
Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. [PDF]
, 2015 Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood and adolescence. The two major histological subtypes of RMS are alveolar RMS, driven by the fusion protein PAX3-FKHR or PAX7-FKHR, and embryonic RMS, which is usually ...
Duan, Zhenfeng +5 more
core +3 more sources
Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia [PDF]
, 2020 Background: Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer-associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy
Chiappalupi, S. +9 more
core +1 more source
A Postnatal Pax7+ Progenitor Gives Rise to Pituitary Adenomas [PDF]
Genes & Cancer, 2010 Pituitary adenomas are classified into functioning and nonfunctioning (silent) tumors on the basis of hormone secretion. However, the mechanism of tumorigenesis and the cell of origin for pituitary adenoma subtypes remain to be elucidated. Employing a tamoxifen-inducible mouse model, we demonstrate that a novel postnatal Pax7(+) progenitor cell ...
Tohru, Hosoyama +11 more
openaire +2 more sources
Multipotency and physiological role of skeletal muscle interstitium-derived stem cells
Journal of Physical Fitness and Sports Medicine, 2012 Multipotent stem cells, other than satellite cells, that can give rise to primary myoblasts postnatally, are present in the interstitial spaces of skeletal muscle.
Tetsuro Tamaki
doaj +1 more source
Adult skeletal muscle stem cell migration is mediated by a blebbing/amoeboid mechanism [PDF]
, 2011 Adult skeletal muscle possesses a resident stem cell population called satellite cells which are responsible for tissue repair following damage. Satellite cell migration is crucial in promoting rapid tissue regeneration but is a poorly understood ...
Collins-Hooper, Henry +4 more
core +1 more source
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. [PDF]
, 2014 The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for this phenomenon are largely unknown.
Chen, Robert Y +8 more
core +1 more source
Shape analysis of the basioccipital bone in Pax7-deficient mice [PDF]
Scientific Reports, 2017 AbstractWe compared the cranial base of newbornPax7-deficient and wildtype mice using a computational shape modeling technology called particle-based modeling (PBM). We found systematic differences in the morphology of the basiooccipital bone, including a broadening of the basioccipital bone and an antero-inferior inflection of its posterior edge in ...
Joshua Cates +8 more
openaire +2 more sources
Bio-ProtocolAdult muscle stem cells (MuSCs) are the key cellular source for regenerating skeletal muscle in vertebrates. MuSCs are typically identified in skeletal muscle by the expression of the paired box protein 7 (PAX7) protein. Here, we developed a combined RNA
Vedant Lakkundi +3 more
doaj +1 more source
Pax7 remodels the chromatin landscape in skeletal muscle stem cells. [PDF]
PLoS ONE, 2017 Pluripotent stem cells (PSC) hold great promise for the treatment of human skeletal muscle diseases. However, it remains challenging to convert PSC to skeletal muscle cells, and the mechanisms by which the master regulatory transcription factor, Pax7 ...
Karin C Lilja +9 more
doaj +1 more source