Results 1 to 10 of about 27,684 (229)
LSD1 Controls Timely MyoD Expression via MyoD Core Enhancer Transcription [PDF]
Cell Reports, 2017 MyoD is a master regulator of myogenesis. Chromatin modifications required to trigger MyoD expression are still poorly described. Here, we demonstrate that the histone demethylase LSD1/KDM1a is recruited on the MyoD core enhancer upon muscle ...
Shinichiro Hayashi +2 more
exaly +8 more sources
The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation [PDF]
Open Biology, 2017 Myogenic progenitor/stem cells retain their skeletal muscle differentiation potential by maintaining myogenic transcription factors such as MyoD. However, the mechanism of how MyoD expression is maintained in proliferative progenitor cells has not been ...
Yasuyuki Ohkawa +2 more
exaly +3 more sources
Loss of MyoD Promotes Fate Transdifferentiation of Myoblasts Into Brown Adipocytes
EBioMedicine, 2017 Brown adipose tissue (BAT) represents a promising agent to ameliorate obesity and other metabolic disorders. However, the abundance of BAT decreases with age and BAT paucity is a common feature of obese subjects. As brown adipocytes and myoblasts share a
Atsushi Asakura +2 more
exaly +4 more sources
MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-κB
Cell Reports, 2016 MyoD is a key regulator of skeletal myogenesis that directs contractile protein synthesis, but whether this transcription factor also regulates skeletal muscle metabolism has not been explored. In a genome-wide ChIP-seq analysis of skeletal muscle cells,
Ruoning Wang +2 more
exaly +4 more sources
Nature Communications, 2021 Rhabdomyosarcomas are tumours blocked in myogenic differentiation, which despite the expression of master muscle regulatory factors, including MYOD, are unable to differentiate.
Silvia Pomella +23 more
doaj +2 more sources
MyoD is a 3D genome structure organizer for muscle cell identity
Nature Communications, 2022 Pioneer transcription factors (TFs) have been proposed to act as protein anchors to orchestrate cell type-specific 3D genome architecture. MyoD is a pioneer TF for myogenic lineage specification.
Ruiting Wang +19 more
doaj +2 more sources
Cells, 2022 The discovery of the skeletal muscle-specific transcription factor MyoD represents a milestone in the field of transcriptional regulation during differentiation and cell-fate reprogramming.
Cecilia Battistelli +2 more
doaj +2 more sources
Master control: transcriptional regulation of mammalian Myod
Journal of Muscle Research and Cell Motility, 2019 MYOD is a master regulator of the skeletal myogenic program. But what regulates expression of Myod? More than 20 years ago, studies established that Myod expression is largely controlled by just two enhancer regions located within a region 24 kb upstream
Fiona C Wardle, Wardle Fiona C
exaly +2 more sources
MyoD Overexpressed Equine Adipose-Derived Stem Cells Enhanced Myogenic Differentiation Potential
Cell Transplantation, 2016 Mesenchymal stem cells could potentially be used in the clinical treatment of muscle disorders and muscle regeneration. Adipose-derived stem cells (ADSCs) can be easily isolated from adipose tissue, as opposed to stem cells of other tissues.
Soo-Eun Sung +8 more
doaj +2 more sources
Stem Cell Reports, 2018 Summary: MyoD and Myf5 are fundamental regulators of skeletal muscle lineage determination in the embryo, and their expression is induced in satellite cells following muscle injury.
Masakazu Yamamoto +7 more
doaj +2 more sources