Results 21 to 30 of about 37,117 (236)
The emergence of Pax7-expressing muscle stem cells during vertebrate head muscle development [PDF]
, 2015 Pax7 expressing muscle stem cells accompany all skeletal muscles in the body and in healthy individuals, efficiently repair muscle after injury. Currently, the in vitro manipulation and culture of these cells is still in its infancy, yet muscle stem ...
Anna eNoble +9 more
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Reversible differentiation of myofibroblasts by MyoD [PDF]
Experimental Cell Research, 2011 Myofibroblasts participate in tissue repair processes in diverse mammalian organ systems. The deactivation of myofibroblasts is critical for termination of the reparative response and restoration of tissue structure and function. The current paradigm on normal tissue repair is the apoptotic clearance of terminally differentiated myofibroblasts; while ...
Louise, Hecker +3 more
openaire +2 more sources
Cell, 1997 A model to account for the role of Pax-3 in myogenesis is shown in Figure 2Figure 2. Not surprisingly, these new studies on the myogenic functions of Pax-3 raise as many questions as they answer. For example, how does Pax-3 activate MyoD expression? Is the MyoD gene a direct target for transcriptional activation by Pax-3 or are there intermediate steps?
Rawls, Alan, Olson, Eric N.
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Six homeoproteins directly activate Myod expression in the gene regulatory networks that control early myogenesis. [PDF]
PLoS Genetics, 2013 In mammals, several genetic pathways have been characterized that govern engagement of multipotent embryonic progenitors into the myogenic program through the control of the key myogenic regulatory gene Myod.
Frédéric Relaix +9 more
doaj +1 more source
Thermal stress induces glycolytic beige fat formation via a myogenic state. [PDF]
, 2019 Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue.
A Jaworski +48 more
core +2 more sources
Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia [PDF]
, 2020 Background: Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer-associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy
Chiappalupi, S. +9 more
core +1 more source
Elderly Health Journal, 2021 Introduction: Although exercise training and herbs consumption have protective effects on many diseases, the mechanism of action of exercise training with different intensities and citrus aurantium (CA) extract consumption on the autophagy-dependent MyoD
Mina jafari +3 more
doaj
Disruption of the MyoD/p21 Pathway in Rhabdomyosarcoma [PDF]
Sarcoma, 1997 Purpose. Rhabdomyosarcoma (RMS) is an embryonal tumor thought to arise from skeletal muscle cells that fail to differentiate terminally. The majority of RMSs express MyoD, a protein essential to the differentiation of skeletal muscle.
Weintraub, Michael +3 more
openaire +2 more sources
Herculin, a Fourth Member of the MyoD Family of Myogenic Regulatory Genes [PDF]
, 1990 We have identified and cloned herculin, a fourth mouse muscle regulatory gene. Comparison of its DNA and deduced amino acid sequences with those of the three known myogenic genes (MyoD, myogenin, and Myf-5) reveals scattered short spans with similarity ...
Miner, Jeffrey H., Wold, Barbara J.
core +1 more source
Smad7:β-catenin Complex Regulates Myogenic Gene Transcription [PDF]
, 2019 Recent reports indicate that Smad7 promotes skeletal muscle differentiation and growth. We previously documented a non-canonical role of nuclear Smad7 during myogenesis, independent of its role in TGF-β signaling.
McDermott, John +2 more
core +1 more source