Results 201 to 210 of about 87,228 (284)

Hederagenin Attenuates Cardiac Remodeling by Targeting Phosphodiesterase 9A

Phytotherapy Research, EarlyView.
ABSTRACT Background and Aim New therapeutic strategies for heart failure are urgently needed. The protective effects of cyclic guanosine monophosphate (cGMP)—protein kinase G (PKG) pathway on heart have been widely reported. Despite phosphodiesterase 9A (PDE9A) inhibitors combating cardiac remodeling, clinically available drugs are lacking. Hederagenin
Liqian Chen, Xinghong Zhou, Yanting You, Jieyu Chen, Baizhao Peng, Yijian Deng, Shuai Ji, Ying Yang, Xiaohu Chen, Huaxi Liu, Shuxuan Yang, Hiu Yee Kwan, Wen Jin, Lei Zhang, Yuegang Wang, Xiaoshan Zhao, Yanyan Liu   +16 more
wiley   +1 more source

A carotid web with accumulation of myofibroblasts: a case report. [PDF]

BMC Neurol
Kotani S, Yasumizu R, Takeuchi Y, Yamanaka T, Kuwayama K, Matsumoto K.   +5 more
europepmc   +1 more source

Disc‐Toroid Hybrid Lipid Nanoparticles for Efficient Drug Encapsulation and Subcutaneous Delivery

Small, EarlyView.
This study demonstrates sub‐50 nm solid‐lipid nanoparticles with long‐term stability, high drug loading, and strong tissue compatibility. Disc‐toroid morphology is confirmed and may play a role in cellular interactions, while low cytotoxicity and minimal systemic permeation confirm depot‐like behavior. These nanoparticles represent a versatile platform
Zanelle van Niekerk, Rima Nuwayhid, Stefaniya Gaydarova, Eva Bittrich, Natalia Makarova, Susanne Boye, Christo Tzachev, Jan C. Simon, Sandra Franz, Albena Lederer   +9 more
wiley   +1 more source

Epigenetic regulatory mechanisms and translational applications in idiopathic pulmonary fibrosis. [PDF]

Am J Clin Exp Immunol
Jiang M, Wang Q, Lyu Y, Hou X, Zhou X.
europepmc   +1 more source

Nodules in an Infant's Fingers

JEADV Clinical Practice, EarlyView.
Adnan Ahmad, Mariam Alshammari, Alsadat Mosbeh, Abeer Albazali, Kawthar Safar, Fatmah Al‐Sughayer   +5 more
wiley   +1 more source

Comparing leukocyte‐ and thrombocyte‐rich fibrin and autologous grafts for the treatment of experimentally induced wounds in the tarsometatarsus of chickens

Veterinary Record, EarlyView.
Abstract Background Managing open wounds in birds is challenging. This study compared leukocyte‐ and thrombocyte‐rich fibrin (L‐TRF) and autologous grafts for treating wounds in the tarsometatarsus of chickens. Methods Full‐thickness wounds were experimentally induced in the tarsometatarsus of 23 healthy adult chickens.
Vivian Ferreira Rech, Sheila Canevese Rahal, Renata Dalcol Mazaro, Luna Scarpari Rolim, Guilherme Rech Cassanego, Matheus Yuri Dos Santos, Rafael Almeida Fighera   +6 more
wiley   +1 more source

Palmar Fascia Fibrosis in Dupuytren's Disease: A Narrative Review of Pathogenic Mechanisms and Molecular Insights. [PDF]

Int J Mol Sci
Pirri C.
europepmc   +1 more source

Potential targets for renal cell carcinoma therapy: Mechanistic research and prospects of CAFs in renal cell carcinoma

VIEW, EarlyView.
Cancer‐associated fibroblasts exert intricate mechanisms in the progression and metastasis of renal cell carcinoma. Existing studies have validated the relevant mechanisms of three signaling pathways, which hold promising potential as novel therapeutic targets.
Ruiqiang Sun, Jiankun Zhang, Meixi Liu, Xiyue Dong, Yuanshan Cui   +4 more
wiley   +1 more source

Human ISG15 deficiency unveils impaired healing of ulcerations via type I interferon-mediated fibrosis. [PDF]

J Hum Immun
Sazeides C, Cuollo L, Sidhu I, Randolph HE, Martin-Fernandez M, Buta S, Stewart OJ, Geltman R, Adalsteinsson JA, Phelps RG, Horowitz A, Stein D, Youssef M, Martinez-Muniz A, Hernandez M, Lionakis MS, Boneparth A, Milner JD, Naik S, Bogunovic D.   +19 more
europepmc   +1 more source